List of works - Nir London

A Fast and Clean BTK Inhibitor

scientific article published on 13 May 2020

An accurate binding interaction model in de novo computational protein design of interactions: If you build it, they will bind ⬇️

scientific article published on April 1, 2013

Anchoring of bacterial effectors to host membranes through host-mediated lipidation by prenylation: a common paradigm.

scientific article published on 7 October 2011

Assessing the energy landscape of CAPRI targets by FunHunt

scientific article

Autophosphorylation Activates Dictyostelium Myosin II Heavy Chain Kinase A by Providing a Ligand for an Allosteric Binding Site in the -Kinase Domain

scientific article

Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?

scientific article

Community-wide assessment of protein-interface modeling suggests improvements to design methodology

scientific article

Correction to Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs

scientific article published on 10 June 2020

Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases

scientific journal article

Covalent flexible peptide docking in Rosetta

scientific article published on 12 July 2021

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

scientific article published on 07 October 2020

Druggable protein-protein interactions--from hot spots to hot segments.

scientific article published on 31 October 2013

Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family

scientific article

FunHunt: model selection based on energy landscape characteristics.

scientific article

Funnel hunting in a rough terrain: learning and discriminating native energy funnels.

scientific article

Hitting KRAS When It's Down

scientific article published on 22 June 2020

Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity

scientific article

Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange

scientific article published on 10 January 2018

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

scientific article published on 10 November 2023

Overcoming insecticide resistance through computational inhibitor design

scientific article published on 01 October 2019

Peptide docking and structure-based characterization of peptide binding: from knowledge to know-how.

scientific article published on 15 October 2013

Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

scientific article published on 10 December 2019

Prediction of substrates for glutathione transferases by covalent docking

scientific article

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

scientific article published on 22 May 2019

Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory Response

scientific article

Relacin, a novel antibacterial agent targeting the Stringent Response

scientific article

RosettaDock in CAPRI rounds 6-12

scientific article (publication date: December 2007)

Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

scientific article published on 21 March 2017

Sub-angstrom modeling of complexes between flexible peptides and globular proteins.

scientific article published in July 2010

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

scientific article published on 10 May 2021

The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK.

scientific article published in March 2011

The structural basis of peptide-protein binding strategies.

scientific article

Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry

scientific article published on 24 March 2021

Ubiquitination and degradation of the inhibitors of NF-kappaB

scientific article

Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents

scientific article (publication date: 16 October 2015)

List of works by Nir London

A Fast and Clean BTK Inhibitor

An accurate binding interaction model in de novo computational protein design of interactions: If you build it, they will bind ⬇️

Anchoring of bacterial effectors to host membranes through host-mediated lipidation by prenylation: a common paradigm.

Assessing the energy landscape of CAPRI targets by FunHunt

Autophosphorylation Activates Dictyostelium Myosin II Heavy Chain Kinase A by Providing a Ligand for an Allosteric Binding Site in the -Kinase Domain

Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?

Community-wide assessment of protein-interface modeling suggests improvements to design methodology

Correction to Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs

Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases

Covalent flexible peptide docking in Rosetta

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Druggable protein-protein interactions--from hot spots to hot segments.

Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family

FunHunt: model selection based on energy landscape characteristics.

Funnel hunting in a rough terrain: learning and discriminating native energy funnels.

Hitting KRAS When It's Down

Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity

Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

Overcoming insecticide resistance through computational inhibitor design

Peptide docking and structure-based characterization of peptide binding: from knowledge to know-how.

Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

Prediction of substrates for glutathione transferases by covalent docking

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory Response

Relacin, a novel antibacterial agent targeting the Stringent Response

RosettaDock in CAPRI rounds 6-12

Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

Sub-angstrom modeling of complexes between flexible peptides and globular proteins.

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK.

The structural basis of peptide-protein binding strategies.

Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry

Ubiquitination and degradation of the inhibitors of NF-kappaB

Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents