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List of works by Eric W Hewitt

A Balance of Opposing Signals within the Cytoplasmic Tail Controls the Lysosomal Targeting of P-selectin

scientific article published in Journal of Biological Chemistry

A complex web of signal-dependent trafficking underlies the triorganellar distribution of P-selectin in neuroendocrine PC12 cells.

scientific article published on June 1999

A new era for understanding amyloid structures and disease ⬇️

scientific article published on 01 December 2018

A systematic study of the effect of physiological factors on beta2-microglobulin amyloid formation at neutral pH.

scientific article published in February 2006

Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils ⬇️

scientific article published on August 2013

Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease? ⬇️

scientific article

An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.

scientific article

Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells ⬇️

scientific article

Antigen presentation: peptides and proteins scramble for the exit.

scientific article

Cellular proteostasis: degradation of misfolded proteins by lysosomes ⬇️

scientific article

Characterization of the response of primary cells relevant to dialysis-related amyloidosis to β2-microglobulin monomer and fibrils ⬇️

scientific article

Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase

scientific article published on 21 March 1997

Comparison of the aggregation of homologous β2-microglobulin variants reveals protein solubility as a key determinant of amyloid formation ⬇️

scientific article

Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid

scientific article published in August 2005

Deletion analysis of yeast Sec65p reveals a central domain that is sufficient for function in vivo ⬇️

scientific article published on August 1, 1998

Dependence of the localization and function of the human cytomegalovirus protein US6 on the transporter associated with antigen processing

scientific article published on 13 May 2009

Di-leucine signals mediate targeting of tyrosinase and synaptotagmin to synaptic-like microvesicles within PC12 cells.

scientific article published on November 1999

Direct three-dimensional visualization of membrane disruption by amyloid fibrils

scientific article

Fibril fragmentation enhances amyloid cytotoxicity

scientific article published on 6 October 2009

Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters

scientific article

Immunologic human renal allograft injury associates with an altered IL-10/TNF-α expression ratio in regulatory B cells

scientific article

Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils

scientific article published on 8 August 2007

Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway

scientific article published on 15 April 2009

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein ⬇️

scientific article published on 28 August 2011

Natural killer cell cytotoxicity: how do they pull the trigger?

scientific article published on September 2009

Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation.

scientific article published on November 1997

Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome

scientific article published on 31 January 2007

Powering the peptide pump: TAP crosstalk with energetic nucleotides

scientific article published in September 2002

Specific glycosaminoglycans promote unseeded amyloid formation from beta2-microglobulin under physiological conditions.

scientific article published on 2 May 2007

Structural and Functional Dissection of the Human Cytomegalovirus Immune Evasion Protein US6.

scientific article published on 16 January 2008

Structural mapping of oligomeric intermediates in an amyloid assembly pathway

scientific article published on 25 September 2019

Synaptotagmin I-DeltaC2B. A novel synaptotagmin isoform with a single C2 domain in the bovine adrenal medulla

scientific article

The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP

scientific journal article

The MHC class I antigen presentation pathway: strategies for viral immune evasion ⬇️

scientific article published on October 1, 2003

The S. cerevisiae SEC65 gene encodes a component of yeast signal recognition particle with homology to human SRP19

scientific article published on April 9, 1992

The human cytomegalovirus gene product US6 inhibits ATP binding by TAP

scientific article

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding

scientific article published on 24 March 2000

Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation

scientific article published on May 2002

Virus subversion of protective immunity

scientific article published in September 2004

Why are Functional Amyloids Non-Toxic in Humans? ⬇️

scientific article published on 22 September 2017

pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers ⬇️

scientific article published on 20 April 2015

β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH ⬇️

scientific article

β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes ⬇️

scientific article

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