List of works by Adam D Bachstetter

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

scientific article published on 10 April 2015

Blockade of caspase-1 increases neurogenesis in the aged hippocampus.

scientific article published in November 2007

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.

scientific article

Cardiac arrest with cardiopulmonary resuscitation reduces dendritic spine density in CA1 pyramidal cells and selectively alters acquisition of spatial memory.

scientific article published in October 2004

Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain

scientific article published on 05 December 2013

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

scientific article published on April 2015

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

scientific article published on 24 May 2013

Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy.

scientific article

Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models

scientific article

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

scientific article

Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats

scientific article published on 12 September 2008

Diffuse brain injury induces acute post-traumatic sleep

scientific article published on 08 January 2014

Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge

scientific article published on 13 May 2016

Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

scientific article published on 23 May 2015

Early inhibition of TNFalpha increases 6-hydroxydopamine-induced striatal degeneration.

scientific article published on 7 February 2007

Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms.

scientific article published on 26 May 2006

Generation and behavior characterization of CaMKIIβ knockout mice

scientific article

Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature

scientific article

Increased neuronal proliferation in the dentate gyrus of aged rats following neural stem cell implantation.

scientific article

Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis

scientific article

Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.

scientific article published on 11 July 2014

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses

scientific article published on 12 February 2016

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

scientific article published on 20 December 2011

Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury.

scientific article published on 22 May 2018

Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls

scientific article published on 16 January 2007

Optimization and validation of a modified radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury

scientific article published on 18 August 2020

Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi

scientific article

Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain

scientific article

Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury

scientific article published on 3 May 2016

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.

scientific article

Rod-shaped microglia morphology is associated with aging in 2 human autopsy series

scientific article published on 5 January 2017

Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation

scientific article (publication date: 5 May 2010)

Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

scientific article

Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

scientific article published on November 2012

Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.

scientific article

Targeting innate immunity for neurodegenerative disorders of the central nervous system

scientific article

The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review

scientific article published on 11 January 2020

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

scientific article

The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.

scientific article published on April 2013

The role of microglia in adult hippocampal neurogenesis

scientific article

Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury

scientific article

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

scientific article

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