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List of works by Vincenza Andrisano

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies

scientific article

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents

scientific article published on 2 November 2012

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

scientific article published on 14 July 2015

3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy

scientific article published in June 2003

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

scientific article

A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation

scientific article

A small molecule targeting the multifactorial nature of Alzheimer's disease

scientific article published in January 2007

AFM study of F-actin on chemically modified surfaces

Acetylcholinesterase inhibition by tacrine analogues

scientific article published in 1997

Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives

Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.

scientific article published in October 1998

Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment.

scientific article published on 4 September 2012

Analysis and enantioresolution of donepezil by capillary electrophoresis.

scientific article published in March 2001

Analysis of ACE inhibitors in pharmaceutical dosage forms by derivative UV spectroscopy and liquid chromatography (HPLC).

scientific article

Analysis of aliphatic dicarboxylic acids in pharmaceuticals and cosmetics by liquid chromatography (HPLC) with fluorescence detection

scientific article published on 01 April 1995

Analysis of human histone H4 by capillary electrophoresis in a pullulan-coated capillary, LC-ESI-MS and MALDI-TOF-MS.

scientific article

Analysis of pharmaceutical creams: a useful approach based on solid-phase extraction (SPE) and UV spectrophotometry

scientific article published on 01 October 1995

Analytical study of penicillamine in pharmaceuticals by capillary zone electrophoresis

Application of high-performance liquid chromatography with diode-array detection and on-line post-column photochemical derivatization to the determination of analgesics

scientific article published on 01 April 1996

Batchwise covalent immobilization of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies

scientific article published on 12 April 2005

Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity

scientific article

Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

scientific article published on 22 February 2011

Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors

scientific article published on 20 April 2011

Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities

scientific article published in August 2010

Capillary electrophoretic and high-performance liquid chromatographic studies of the enantioselective separation of alpha1-adrenoreceptor antagonists.

scientific article published in April 1998

Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor

Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease

scientific article published on 24 August 2011

Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones

scientific article published in 2007

Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation

scientific article published in June 2005

Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery.

scientific article published in February 2005

Concise Enantioselective Synthesis and Attribution of the Absolute Configuration of Two-Carbon Bridge Methoxylated Cocaines and Pseudococaines

Dermatan sulfate as useful chiral selector in capillary electrophoresis ⬇️

scientific article published on July 24, 1998

Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors

scientific article

Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues

scientific article published in November 2004

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease

scientific article published on November 2005

Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors

scientific article published in 2006

Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase

scientific article

Determination of dextromethorphan and levomethorphan in seized heroin samples by enantioselective HPLC and electronic CD

scholarly article by Daniele Tedesco et al published July 2013 in Journal of Pharmaceutical and Biomedical Analysis

Determination of levamisole and tetramisole in seized cocaine samples by enantioselective high-performance liquid chromatography and circular dichroism detection.

scientific article published on 29 July 2014

Determination of the chiral and achiral related substances of methotrexate by cyclodextrin-modified micellar electrokinetic chromatography

scientific article published in August 2004

Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography.

scientific article

Determination of triclosan in personal health care products by liquid chromatography (HPLC).

scientific article

Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies

scientific article

Development and characterization of beta-secretase monolithic micro-immobilized enzyme reactor for on-line high-performance liquid chromatography studies

scientific article published on 22 October 2007

Development of a liquid chromatographic system with fluorescent detection for beta-secretase immobilized enzyme reactor on-line enzymatic studies

scientific article published on 22 July 2009

Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies.

scientific article

Disclosure of a fundamental clue for the elucidation of the myricetin mechanism of action as amyloid aggregation inhibitor by mass spectrometry.

scientific article

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

scientific article published on 28 December 2020

Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.

scientific article

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease

scientific article published on 8 September 2011

Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives

Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase

scientific article

Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease

scientific article

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold

scholarly article by Angela Rampa published in July 2015

From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease

scientific article published on 24 March 2014

GC-FID/MS method for the impurity profiling of synthetic d-allethrin

scientific article published in January 2004

GC–MS analysis of incenses for possible presence of allergenic nitromusks

scientific article published on 01 July 1998

Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery?

scientific article published on 21 December 2020

HPLC analysis of imidazole antimycotic drugs in pharmaceutical formulations

article

HPLC analysis of liquorice triterpenoids — applications to the quality control of pharmaceuticals

scientific article published on 01 April 1995

HPLC determination of glutathione and l-cysteine in pharmaceuticals after derivatization with ethacrynic acid

scientific article published on 01 January 1994

Heterocyclic inhibitors of AChE acylation and peripheral sites

scientific article

Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.

scientific article

Histone post-translational modifications by HPLC-ESI-MS after HT29 cell treatment with histone deacetylase inhibitors

scientific article published in December 2009

Histone proteins determined in a human colon cancer by high-performance liquid chromatography and mass spectrometry.

scientific article published on 2 August 2006

Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library

scientific article

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases

scientific article

Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease

scientific article published on 04 October 2008

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush

scientific article published on 8 July 2008

Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action

scientific article

Investigating in Vitro Amyloid Peptide 1-42 Aggregation: Impact of Higher Molecular Weight Stable Adducts

scientific article published on 18 July 2019

Investigation of the photochemical properties and in vitro phototoxic potential of bumetanide

scientific article published on October 2003

Investigation of the photostability properties of memoquin, a quinone derivative for the treatment of Alzheimer's disease.

scientific article published on 23 April 2009

Kinetic characterization of amyloid-beta 1-42 aggregation with a multimethodological approach.

scientific article

LC Analysis of Oxytetracycline and Chlortetracycline: Application for In Vitro Bio-Equivalence Study of Veterinary Medicines

LC-MS method for the simultaneous determination of six glucocorticoids in pharmaceutical formulations and counterfeit cosmetic products

scholarly article by Jessica Fiori et al published March 2014 in Journal of Pharmaceutical and Biomedical Analysis

Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid peptide as fluorogenic substrate

scholarly article by Angela De Simone et al published 15 March 2014 in Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences

Mass spectrometry as an efficient tool for the characterization of amyloid β peptide 25-35 self-assembly species in aggregation and inhibition studies

scientific article

Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid in colon cancer.

scientific article published on 17 July 2012

Monolithic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies.

scientific article published in March 2004

Monolithic stationary phase coupled with coulometric detection: development of an ion-pair HPLC method for the analysis of quinone-bearing compounds

scientific article published in November 2007

Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers

scientific article published on 8 July 2011

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

scientific article published on 4 October 2007

Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease

scientific article published on 30 November 2007

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation

scientific article

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

scientific article published on 30 March 2012

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives

scientific article published on 28 October 2015

Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects

scientific article

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

scientific article published on 11 December 2014

Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

article by Maria Laura Bolognesi et al published 1 May 2011 in Bioorganic & Medicinal Chemistry Letters

Multiwell fluorometric and colorimetric microassays for the evaluation of beta-secretase (BACE-1) inhibitors

scientific article published on 31 May 2007

Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease

scientific article published on 26 October 2015

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease

scientific article published on 16 February 2016

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease

scientific article published on 13 September 2007

Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

scientific article published on 3 June 2008

Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates

scientific article

Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids

scientific article published on 23 December 2014

On-line post-column photochemical derivatization in liquid chromatographic—diode-array detection analysis of binary drug mixtures

article

Optimization of a trypsin-bioreactor coupled with high-performance liquid chromatography-electrospray ionization tandem mass spectrometry for quality control of biotechnological drugs.

scientific article published on 3 February 2006

Photomutagenic properties of terfenadine as revealed by a stepwise photostability, phototoxicity and photomutagenicity testing approach.

scientific article published on April 2003

Photostability studies on the furosemide-triamterene drug association.

scientific article published in September 2003

Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation

scientific article published in January 2005

Protective effects of cyanidin-3-O-beta-glucopyranoside against UVA-induced oxidative stress in human keratinocytes.

scientific article published on May 2005

Protein flexibility in virtual screening: the BACE-1 case study

scientific article

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds

scientific article published in September 2009

Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks

scientific article published on 26 August 2019

Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease

scientific article published on 5 October 2013

Rational approach to discover multipotent anti-Alzheimer drugs.

scientific article

Reliable assay of extreme enantiomeric purity values by a new circular dichroism based HPLC detection system

scientific article published on 01 February 2000

Reprint of: Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid peptide as fluorogenic substrate

scholarly article by Angela De Simone et al published 1 October 2014 in Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences

Retraction notice to: “Simultaneous micellar electrokinetic chromatography and liquid chromatography of adriblastina and tarabine PFS: Their application to some biological fluids” [Talanta 66 (2005) 253–260]

scientific article published on 01 June 2009

Self-assembly of biomolecules: AFM study of F-actin on unstructured and nanostructured surfaces

Semisynthetic chondroitins as chiral buffer additives in capillary electrophoresis.

scientific article published on June 1999

Separation and quantitation of fructose-6-phosphate and fructose-1 ,6-diphosphate by LC-ESI-MS for the evaluation of fructose-1,6-biphosphatase activity

scholarly article by Francesca Mancini et al published October 2006 in Journal of Separation Science

Sequential Virtual Screening Approach to the Identification of Small Organic Molecules as Potential BACE-1 Inhibitors

article

Simultaneous micellar electrokinetic chromatography and liquid chromatography of adriblastina and tarabine PFS Their application to some biological fluids

scientific article published on 24 December 2004

Simultaneous separation and determination of Tarabine PFS and Adriblastine using micellar electrokinetic chromatography and high performance liquid chromatography. Application to some biological fluids

scientific article published in April 2005

Stereoselective determination of allethrin by two-dimensional achiral/chiral liquid chromatography with ultraviolet/circular dichroism detection.

scientific article published in August 2004

Stereoselectivity at alpha-adrenoreceptor subtypes: observations with the enantiomers of WB 4101 separated through their amides of N-tosyl-(S)-proline

scientific article published on January 1, 1992

Strategies for the inhibition of protein aggregation in human diseases

scientific article published on May 2010

Structural characterization of p53 isoforms due to the polymorphism at codon 72 by mass spectrometry and circular dichroism

scientific article

Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine

scientific article published in April 2009

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine

scientific article published in March 2003

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties

scientific article published in December 2004

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer

Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.

scientific article

Studies on the photostability and in vitro phototoxicity of Labetalol.

scientific article

Study of donepezil binding to serum albumin by capillary electrophoresis and circular dichroism

scientific article published on 3 September 2003

Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors.

scientific article published on 29 August 2012

Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

scientific article

Synthesis and partition profiles of nicotinic acid derivatives with oligomeric carriers

Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.

scientific article published on 23 November 2011

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.

scientific article published on 16 February 2010

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease

scientific article published on May 2009

Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.

scientific article

The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?

scientific article

The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon

scientific article

The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90 ⬇️

scientific article published on March 21, 2012

The role of Li+, Na+, and K+ in the ligand binding inside the human acetylcholinesterase gorge

Thermal and catalytic reactions of ethyl diazopyruvate with [60]fullerene

Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks

scientific article published on December 2009

Two-carbon bridge substituted cocaines: enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and 7-methoxylated cocaines.

scientific article

UHPLC determination of catechins for the quality control of green tea.

scientific article published on 12 September 2013

Ubiquitous amyloids

scientific article

Unusual reaction of 1,4-diamino-2-nitrobenzene derivatives toward nucleophiles: Catalysis by sodium sulphite

Use of an immobilised human serum albumin HPLC column as a probe of drug-protein interactions: the reversible binding of valproate.

scientific article

Vasoactive cocktails for erectile dysfunction: chemical stability of PGE1, papaverine and phentolamine

article by Marcello Soli et al published August 1998 in Journal of Urology

[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors

scientific article published in 2000

beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies

scientific article published in February 2003

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