List of works - Vladimir Buchman

A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice

scientific article published on 23 March 2021

Absence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice

scientific article

Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex

scientific article

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

scientific article

Autoantibodies to alpha-synuclein in inherited Parkinson's disease.

scientific article

C9ORF72 hexanucleotide repeat expansion in ALS patients from the Central European Russia population

scientific article published on 09 July 2015

CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human gene

article

Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis.

scientific article published on 10 April 2015

Chronic administration of Dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice.

scientific article

Chronic administration of dimebon ameliorates pathology in TauP301S transgenic mice.

scientific article published in January 2013

Cloning and developmental expression of MARK/Par-1/MELK-related protein kinase xMAK-V in Xenopus laevis

scientific article published on 23 January 2004

Compromised paraspeckle formation as a pathogenic factor in FUSopathies

scientific article

Contrasting effects of α-synuclein and γ-synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal synapses.

scientific article

Deletion of alpha-synuclein decreases impulsivity in mice.

scientific article published on 29 December 2011

Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice

scientific journal article

Differential expression of sarcoplasmic and myofibrillar proteins of rat soleus muscle during denervation atrophy.

scientific article published on 7 August 2009

Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice.

scientific article published on 12 May 2011

Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy.

scientific article published on 17 March 2010

Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra

scientific article published on 8 August 2013

Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family

scientific article

Gamma-synuclein pathology in amyotrophic lateral sclerosis

scientific article

Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein

scientific article

HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions

scientific article

In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches

scientific article published on 20 August 2020

Increased levels of the HER1 adaptor protein Rukl/CIN85 contribute to breast cancer malignancy.

scientific article published on 12 July 2012

Increased lipolysis and altered lipid homeostasis protect γ-synuclein-null mutant mice from diet-induced obesity

scientific article

Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation

scientific article

Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice

scientific article

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.

scientific article

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

scientific article published on October 2016

Multiple domains of Ruk/CIN85/SETA/CD2BP3 are involved in interaction with p85alpha regulatory subunit of PI 3-kinase.

scientific article

Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.

scientific article

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma.

scientific article

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

scientific article published in March 2004

Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.

scientific article

Pro-survival activity of the MAK-V protein kinase in PC12 cells

scientific article published on October 2010

Protein aggregation in retinal cells and approaches to cell protection.

scientific article published on September 2005

Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm

scientific article

Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive "low footprint" genetic knockout of alpha-synuclein

scientific article published on 11 May 2020

Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat

scientific article published on 12 April 2013

Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons

scientific article

Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis

scientific article

Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation

scientific article

Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein.

scientific article published on 22 February 2007

α-Synuclein and dopamine at the crossroads of Parkinson's disease

scientific article published on 18 October 2010

αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

scientific journal article

γ-synuclein is a novel player in the control of body lipid metabolism

scientific article published on 28 May 2013

List of works by Vladimir Buchman

A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice

Absence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice

Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

Autoantibodies to alpha-synuclein in inherited Parkinson's disease.

C9ORF72 hexanucleotide repeat expansion in ALS patients from the Central European Russia population

CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human gene

Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis.

Chronic administration of Dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice.

Chronic administration of dimebon ameliorates pathology in TauP301S transgenic mice.

Cloning and developmental expression of MARK/Par-1/MELK-related protein kinase xMAK-V in Xenopus laevis

Compromised paraspeckle formation as a pathogenic factor in FUSopathies

Contrasting effects of α-synuclein and γ-synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal synapses.

Deletion of alpha-synuclein decreases impulsivity in mice.

Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice

Differential expression of sarcoplasmic and myofibrillar proteins of rat soleus muscle during denervation atrophy.

Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice.

Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy.

Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra

Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family

Gamma-synuclein pathology in amyotrophic lateral sclerosis

Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein

HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions

In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches

Increased levels of the HER1 adaptor protein Rukl/CIN85 contribute to breast cancer malignancy.

Increased lipolysis and altered lipid homeostasis protect γ-synuclein-null mutant mice from diet-induced obesity

Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation

Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

Multiple domains of Ruk/CIN85/SETA/CD2BP3 are involved in interaction with p85alpha regulatory subunit of PI 3-kinase.

Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma.

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.

Pro-survival activity of the MAK-V protein kinase in PC12 cells

Protein aggregation in retinal cells and approaches to cell protection.

Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm

Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive "low footprint" genetic knockout of alpha-synuclein

Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat

Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons

Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis

Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation

Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein.

α-Synuclein and dopamine at the crossroads of Parkinson's disease

αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

γ-synuclein is a novel player in the control of body lipid metabolism