List of works - Gloria López-Castejón

Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway

scientific article published on 10 September 2013

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling

scientific article

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

scientific article published on 03 November 2020

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

scientific article published on 25 January 2017

Caspase-1: is IL-1 just the tip of the ICEberg?

scientific article published on 05 July 2012

Cell volume regulation modulates NLRP3 inflammasome activation

scientific article

Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta

scientific article published on 11 July 2006

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

article published in the Proceedings of the National Academy of Sciences of the United States of America

Control of the inflammasome by the ubiquitin system

scientific article published on 20 November 2019

Current status of inflammasome blockers as anti-inflammatory drugs

scientific article published on 22 May 2012

Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome

scientific article

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

scientific article published on 3 December 2012

Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?

scientific article

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

scientific article published on 14 April 2017

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

scientific article

Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β.

scientific article published on 28 March 2012

Functional Reconstruction of NLRs in HEK293 Cells

scientific article published on 01 January 2016

Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes

scientific article

Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues

scientific article

Mechanisms of NLRP3 priming in inflammaging and age related diseases

scientific article published on 24 August 2020

Method to Measure Ubiquitination of NLRs.

scientific article published in January 2016

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.

scientific article published on 13 February 2013

Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish

scientific article published on 3 July 2007

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

scientific article

Nanoparticles can cause DNA damage across a cellular barrier

scientific article

Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules

article

P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases

scientific article published on 16 July 2010

P2X7 receptor-dependent tuning of gut epithelial responses to infection

scientific article

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro

scientific article published on 30 September 2020

Pro-IL-1β Is an Early Prognostic Indicator of Severe Donor Lung Injury During Ex Vivo Lung Perfusion

scientific article published on 22 September 2020

Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition ⬇️

scientific article published on 15 May 2020

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

scientific article published on 26 August 2019

Response to Boyle et al

scientific article

Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness

scientific article published on 06 November 2011

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.

scientific article

The NLRP3-inflammasome as a sensor of organelle dysfunction

scientific article published on 01 December 2020

The activation of gilthead seabream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish

scientific article published on 07 November 2006

The colony-stimulating factor-1 receptor is a specific marker of macrophages from the bony fish gilthead seabream

scientific article published on 30 August 2005

The inflammasomes, immune guardians at defence barriers

scholarly article by Pablo Palazon-Riquelme & Gloria López-Castejón published 1 November 2018 in Immunology

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

scientific article

The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabream Sparus aurata is strongly induced after infection and tightly regulated at transcriptional and post-transcriptional levels

scientific article published on 17 January 2007

Turbot TNFα gene: Molecular characterization and biological activity of the recombinant protein

article

Two zinc uptake systems contribute to the full virulence of Listeria monocytogenes during growth in vitro and in vivo

scientific article published on 24 October 2011

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

scholarly article by Pablo Palazon-Riquelme published in October 2018

Understanding the mechanism of IL-1β secretion

scientific article published on August 2011

Zinc depletion regulates the processing and secretion of IL-1β.

scientific article published on 30 January 2014

List of works by Gloria López-Castejón

Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

Caspase-1: is IL-1 just the tip of the ICEberg?

Cell volume regulation modulates NLRP3 inflammasome activation

Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

Control of the inflammasome by the ubiquitin system

Current status of inflammasome blockers as anti-inflammatory drugs

Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β.

Functional Reconstruction of NLRs in HEK293 Cells

Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes

Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues

Mechanisms of NLRP3 priming in inflammaging and age related diseases

Method to Measure Ubiquitination of NLRs.

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.

Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

Nanoparticles can cause DNA damage across a cellular barrier

Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules

P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases

P2X7 receptor-dependent tuning of gut epithelial responses to infection

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro

Pro-IL-1β Is an Early Prognostic Indicator of Severe Donor Lung Injury During Ex Vivo Lung Perfusion

Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition ⬇️

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

Response to Boyle et al

Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.

The NLRP3-inflammasome as a sensor of organelle dysfunction

The activation of gilthead seabream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish

The colony-stimulating factor-1 receptor is a specific marker of macrophages from the bony fish gilthead seabream

The inflammasomes, immune guardians at defence barriers

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabream Sparus aurata is strongly induced after infection and tightly regulated at transcriptional and post-transcriptional levels

Turbot TNFα gene: Molecular characterization and biological activity of the recombinant protein

Two zinc uptake systems contribute to the full virulence of Listeria monocytogenes during growth in vitro and in vivo

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

Understanding the mechanism of IL-1β secretion

Zinc depletion regulates the processing and secretion of IL-1β.