List of works - Daniele Torella

A new rat model of small vessel stenting

scientific article published on 01 June 2000

Absence of evidence is not evidence of absence: pitfalls of cre knock-ins in the c-Kit locus.

scientific article

Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury

scientific article published on 28 July 2016

Administration of a loading dose has no additive effect on platelet aggregation during the switch from ongoing clopidogrel treatment to ticagrelor in patients with acute coronary syndrome.

scientific article published on 21 January 2014

Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?

scientific article published on 07 February 2019

Adult c-kit pos Cardiac Stem Cells Fulfill Koch’s Postulates as Causal Agents for Cardiac Regeneration

scientific article published on 14 February 2014

Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair.

scientific article published on August 2013

Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification ⬇️

scientific article published on 11 August 2017

Adult cardiac stem cells are multipotent and support myocardial regeneration

scientific article (publication date: 19 September 2003)

Aging exacerbates negative remodeling and impairs endothelial regeneration after balloon injury

scientific article

Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and c-kitposCD45negCD31neg cardiac stem cell activation

scientific article published on 12 April 2018

Aspiration thrombectomy: an easily forgiven "latecomer"

scientific article published on 19 February 2014

Atrial fibrillation ablation induces reverse remodelling and impacts cardiac function

scientific article published on 01 February 2011

Atrial myxomas arise from multipotent cardiac stem cells

scientific article published on 24 April 2020

Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion

scientific article published on 29 November 2004

Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy

scientific article (publication date: 26 March 2014)

Cardiac Autonomic Regulation in Response to a Mixed Meal Is Impaired in Obese Children and Adolescents: The Role Played by Insulin Resistance

scientific article published on 19 May 2014

Cardiac Stem Cells Possess Growth Factor-Receptor Systems That After Activation Regenerate the Infarcted Myocardium, Improving Ventricular Function and Long-Term Survival

article by Konrad Urbanek et al published 30 September 2005 in Circulation Research

Cardiac adaptations from 4 weeks of intensity-controlled vigorous exercise are lost after a similar period of detraining. ⬇️

scientific article

Cardiac stem and progenitor cell identification: different markers for the same cell?

scientific article published on January 2010

Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression

scientific article published on 15 January 2004

Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function

scientific article

Clinical and Procedural Outcomes of 5-French versus 6-French Sheaths in Transradial Coronary Interventions

scientific article

Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility

scientific article published on 17 February 2021

Combining cell and gene therapy to advance cardiac regeneration

scientific article published on 19 January 2018

Delayed sudden radial artery rupture after left transradial coronary catheterization: a case report

scientific article published on March 2015

Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K.

scientific article

Effect of stent coating alone on in vitro vascular smooth muscle cell proliferation and apoptosis ⬇️

scientific article published on October 30, 2003

Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats.

scientific article published in June 2001

Endogenous Cardiac Stem Cell Activation by Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Intracoronary Injection Fosters Survival and Regeneration of the Infarcted Pig Heart

scientific article published in August 2011

Erratum. miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes. Diabetes 2018;67:2554-2568

scientific article published on 20 February 2020

Gene therapy for restenosis after balloon angioplasty and stenting.

scientific article

Generation of new cardiomyocytes after injury: de novo formation from resident progenitors vs. replication of pre-existing cardiomyocytes.

scientific article published on May 2015

Genetically modified animal models to study cardiovascular disorders

scientific article published on 01 September 2000

Growth-factor-mediated cardiac stem cell activation in myocardial regeneration

scientific article published in February 2007

HMGA1 is a novel candidate gene for myocardial infarction susceptibility

scientific article published on 9 November 2016

Heterogeneity of Adult Cardiac Stem Cells

scientific article published on 01 January 2019

High sensitive troponin T in individuals with chest pain of presumed ischemic origin.

scientific article published in June 2012

Hindlimb Ischemia Impairs Endothelial Recovery and Increases Neointimal Proliferation in the Carotid Artery.

scientific article published on 15 January 2018

Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation

scientific article published in October 2002

In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes

scientific article published on 30 September 2021

Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease.

scientific article

Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy

scientific article published on 19 August 2003

Intracoronary abciximab reduces death and major adverse cardiovascular events in acute coronary syndromes: a meta-analysis of clinical trials.

scientific article published on 27 December 2012

Intracoronary versus intravenous abciximab bolus administration

scientific article published on 08 January 2014

Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart. ⬇️

scientific article

Kitcre knock-in mice fail to fate-map cardiac stem cells

scientific article published in March 2018

LOWERing the INtensity of oral anticoaGulant Therapy in patients with bileaflet mechanical aortic valve replacement: results from the "LOWERING-IT" Trial.

scientific article published on July 2010

Left radial access for percutaneous coronary procedures: from neglected to performer? A meta-analysis of 14 studies including 7,603 procedures

scientific article published on 23 November 2013

Low-dose anticoagulation after isolated mechanical aortic valve replacement with Liva Nova Bicarbon prosthesis: A post hoc analysis of LOWERING-IT Trial.

scientific article

Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy.

scientific article published on 29 April 2011

Mediterranean jellyfish sting-induced Tako-Tsubo cardiomyopathy

scientific article published on 27 September 2010

MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts.

scientific article

Migration of a stent from left main and its retrieval from femoral artery: A case report.

scientific article published in December 2017

Mitogen-activated protein kinases activation in T lymphocytes of patients with acute coronary syndromes.

scientific article

Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor.

scientific article published on 6 June 2016

Molecular basis of functional myogenic specification of Bona Fide multipotent adult cardiac stem cells

scientific article published on 25 June 2018

Molecular mechanisms of in-stent restenosis and approach to therapy with eluting stents.

scientific article

Monographic issue of pharmacological research on adult myocardial repair/regeneration.

scientific article published in January 2018

Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure

scientific article

Myocyte death and renewal: modern concepts of cardiac cellular homeostasis.

scientific article published on February 2007

Neointimal proliferation is associated with clinical restenosis 2 years after fully bioresorbable vascular scaffold implantation.

scientific article published in July 2014

Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions-A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology

scientific article

Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes

scientific article published on 26 February 2004

OFFgel-based multidimensional LC-MS/MS approach to the cataloguing of the human platelet proteome for an interactomic profile

Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms ⬇️

scientific article published on August 31, 2011

Proteomics reveals high levels of vitamin D binding protein in myocardial infarction

scientific article published in June 2010

Rat carotid artery dilation by PTCA balloon catheter induces neointima formation in presence of IEL rupture

scientific article published on 01 August 2002

Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration.

scientific article

Resident progenitors and bone marrow stem cells in myocardial renewal and repair

scientific article

Response to Molkentin's letter to the editor regarding article, "the absence of evidence is not evidence of absence: the pitfalls of Cre knock-ins in the c-kit locus".

scientific article published in December 2014

Response to letter regarding, "administration of a loading dose has no additive effect on platelet aggregation during the switch from ongoing clopidogrel treatment to ticagrelor in patients with acute coronary syndrome"

scientific article published on 01 August 2014

Role of c-Kit in Myocardial Regeneration and Aging

scientific article published on 19 June 2019

Routine ganglionic plexi ablation during Maze procedure improves hospital and early follow-up results of mitral surgery.

scientific article published on 19 May 2008

Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure

scientific article published on 04 September 2003

Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells

scientific article published on 26 October 2020

Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function

scientific article

Subclinical myocardial dysfunction and cardiac autonomic dysregulation are closely associated in obese children and adolescents: the potential role of insulin resistance.

scientific article published on 23 April 2015

Sustained delivery of insulin-like growth factor-1/hepatocyte growth factor stimulates endogenous cardiac repair in the chronic infarcted pig heart.

scientific article published on 07 January 2014

Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease

scientific article published on 26 June 2020

Testing Regeneration of Human Myocardium Without Knowing the Identity and the Number of Effective Bone Marrow Cells Transplanted: Are the Results Meaningful?

scientific article published in July 2006

The adult heart responds to increased workload with physiologic hypertrophy, cardiac stem cell activation, and new myocyte formation ⬇️

scientific article published on 25 October 2012

The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult.

scientific article published on 29 April 2014

The duration of balloon inflation affects the luminal diameter of coronary segments after bioresorbable vascular scaffolds deployment.

scientific article published on 11 December 2015

The instantaneous wave-free ratio (iFR) for evaluation of non-culprit lesions in patients with acute coronary syndrome and multivessel disease.

scientific article published on 28 October 2014

The present and future of drug-eluting stents.

scientific article

The role of endothelial progenitor and cardiac stem cells in the cardiovascular adaptations to age and exercise.

scientific article published on January 2009

The use and abuse of Cre/Lox recombination to identify adult cardiomyocyte renewal rate and origin

scientific article

Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair ⬇️

scientific article published on 25 May 2020

What accounts for the higher clinical efficacy of intracoronary abciximab?

scientific article

[Cardiovascular regenerative medicine at the crossroads. Clinical trials of cellular therapy must now be based on reliable experimental data from animals with characteristics similar to human's].

scientific article

[Molecular therapeutic strategies in cardiology]

scientific article

c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration

scientific article published on 04 June 2019

miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes

scientific article published on 26 September 2018

List of works by Daniele Torella

A new rat model of small vessel stenting

Absence of evidence is not evidence of absence: pitfalls of cre knock-ins in the c-Kit locus.

Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury

Administration of a loading dose has no additive effect on platelet aggregation during the switch from ongoing clopidogrel treatment to ticagrelor in patients with acute coronary syndrome.

Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?

Adult c-kit pos Cardiac Stem Cells Fulfill Koch’s Postulates as Causal Agents for Cardiac Regeneration

Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair.

Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification ⬇️

Adult cardiac stem cells are multipotent and support myocardial regeneration

Aging exacerbates negative remodeling and impairs endothelial regeneration after balloon injury

Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and c-kitposCD45negCD31neg cardiac stem cell activation

Aspiration thrombectomy: an easily forgiven "latecomer"

Atrial fibrillation ablation induces reverse remodelling and impacts cardiac function

Atrial myxomas arise from multipotent cardiac stem cells

Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion

Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy

Cardiac Autonomic Regulation in Response to a Mixed Meal Is Impaired in Obese Children and Adolescents: The Role Played by Insulin Resistance

Cardiac Stem Cells Possess Growth Factor-Receptor Systems That After Activation Regenerate the Infarcted Myocardium, Improving Ventricular Function and Long-Term Survival

Cardiac adaptations from 4 weeks of intensity-controlled vigorous exercise are lost after a similar period of detraining. ⬇️

Cardiac stem and progenitor cell identification: different markers for the same cell?

Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression

Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function

Clinical and Procedural Outcomes of 5-French versus 6-French Sheaths in Transradial Coronary Interventions

Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility

Combining cell and gene therapy to advance cardiac regeneration

Delayed sudden radial artery rupture after left transradial coronary catheterization: a case report

Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K.

Effect of stent coating alone on in vitro vascular smooth muscle cell proliferation and apoptosis ⬇️

Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats.

Endogenous Cardiac Stem Cell Activation by Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Intracoronary Injection Fosters Survival and Regeneration of the Infarcted Pig Heart

Erratum. miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes. Diabetes 2018;67:2554-2568

Gene therapy for restenosis after balloon angioplasty and stenting.

Generation of new cardiomyocytes after injury: de novo formation from resident progenitors vs. replication of pre-existing cardiomyocytes.

Genetically modified animal models to study cardiovascular disorders

Growth-factor-mediated cardiac stem cell activation in myocardial regeneration

HMGA1 is a novel candidate gene for myocardial infarction susceptibility

Heterogeneity of Adult Cardiac Stem Cells

High sensitive troponin T in individuals with chest pain of presumed ischemic origin.

Hindlimb Ischemia Impairs Endothelial Recovery and Increases Neointimal Proliferation in the Carotid Artery.

Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation

In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes

Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease.

Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy

Intracoronary abciximab reduces death and major adverse cardiovascular events in acute coronary syndromes: a meta-analysis of clinical trials.

Intracoronary versus intravenous abciximab bolus administration

Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart. ⬇️

Kitcre knock-in mice fail to fate-map cardiac stem cells

LOWERing the INtensity of oral anticoaGulant Therapy in patients with bileaflet mechanical aortic valve replacement: results from the "LOWERING-IT" Trial.

Left radial access for percutaneous coronary procedures: from neglected to performer? A meta-analysis of 14 studies including 7,603 procedures

Low-dose anticoagulation after isolated mechanical aortic valve replacement with Liva Nova Bicarbon prosthesis: A post hoc analysis of LOWERING-IT Trial.

Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy.

Mediterranean jellyfish sting-induced Tako-Tsubo cardiomyopathy

MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts.

Migration of a stent from left main and its retrieval from femoral artery: A case report.

Mitogen-activated protein kinases activation in T lymphocytes of patients with acute coronary syndromes.

Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor.

Molecular basis of functional myogenic specification of Bona Fide multipotent adult cardiac stem cells

Molecular mechanisms of in-stent restenosis and approach to therapy with eluting stents.

Monographic issue of pharmacological research on adult myocardial repair/regeneration.

Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure

Myocyte death and renewal: modern concepts of cardiac cellular homeostasis.

Neointimal proliferation is associated with clinical restenosis 2 years after fully bioresorbable vascular scaffold implantation.

Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions-A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology

Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes

OFFgel-based multidimensional LC-MS/MS approach to the cataloguing of the human platelet proteome for an interactomic profile

Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms ⬇️

Proteomics reveals high levels of vitamin D binding protein in myocardial infarction

Rat carotid artery dilation by PTCA balloon catheter induces neointima formation in presence of IEL rupture

Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration.

Resident progenitors and bone marrow stem cells in myocardial renewal and repair

Response to Molkentin's letter to the editor regarding article, "the absence of evidence is not evidence of absence: the pitfalls of Cre knock-ins in the c-kit locus".

Response to letter regarding, "administration of a loading dose has no additive effect on platelet aggregation during the switch from ongoing clopidogrel treatment to ticagrelor in patients with acute coronary syndrome"

Role of c-Kit in Myocardial Regeneration and Aging

Routine ganglionic plexi ablation during Maze procedure improves hospital and early follow-up results of mitral surgery.

Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure

Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells

Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function

Subclinical myocardial dysfunction and cardiac autonomic dysregulation are closely associated in obese children and adolescents: the potential role of insulin resistance.

Sustained delivery of insulin-like growth factor-1/hepatocyte growth factor stimulates endogenous cardiac repair in the chronic infarcted pig heart.