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List of works by Ana Ruiz-Garcia

A phase 2 trial of dacomitinib (PF-00299804), an oral, irreversible pan-HER (human epidermal growth factor receptor) inhibitor, in patients with advanced non-small cell lung cancer after failure of prior chemotherapy and erlotinib

scientific article

A phase I dose-escalation and pharmacokinetic study of sunitinib in combination with pemetrexed in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer

scientific article

A phase I open-label study to investigate the potential drug-drug interaction between single-dose dacomitinib and steady-state paroxetine in healthy volunteers.

scientific article published on 17 December 2013

A phase I study of sunitinib in combination with FOLFIRI in patients with untreated metastatic colorectal cancer.

scientific article

Characterization of Neutropenia in Advanced Cancer Patients Following Palbociclib Treatment Using a Population Pharmacokinetic-Pharmacodynamic Modeling and Simulation Approach.

scientific article published on 18 April 2017

Effect of axitinib on the QT interval in healthy volunteers.

scientific article published on 15 January 2015

Effect of food on the bioavailability of palbociclib.

scientific article published on 15 February 2017

Effect of food or proton pump inhibitor treatment on the bioavailability of dacomitinib in healthy volunteers.

scientific article published on 14 July 2015

Establishing best practices and guidance in population modeling: an experience with an internal population pharmacokinetic analysis guidance.

scientific article published on 3 July 2013

Intrinsic absolute bioavailability prediction in rats based on in situ absorption rate constants and/or in vitro partition coefficients: 6-fluoroquinolones.

scientific article published in November 2000

Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells.

scientific article published on April 2005

Methods and strategies for assessing uncontrolled drug-drug interactions in population pharmacokinetic analyses: results from the International Society of Pharmacometrics (ISOP) Working Group

scientific article published on 2 February 2016

Palbociclib has no clinically relevant effect on the QTc interval in patients with advanced breast cancer

scientific article

Pharmacokinetic/Pharmacodynamic Modeling to Support the Re-approval of Gemtuzumab Ozogamicin

scientific article published on 09 July 2019

Pharmacokinetics in drug discovery

scientific article (publication date: February 2008)

Pharmacokinetics of single-agent axitinib across multiple solid tumor types.

scientific article published on 22 October 2014

Phase I and pharmacokinetic study of dacomitinib (PF-00299804), an oral irreversible, small molecule inhibitor of human epidermal growth factor receptor-1, -2, and -4 tyrosine kinases, in Japanese patients with advanced solid tumors

scientific article

Phase II study of sunitinib as second-line treatment for advanced gastric cancer

scientific article

Population pharmacokinetics of inotuzumab ozogamicin in relapsed/refractory acute lymphoblastic leukemia and non-Hodgkin lymphoma

scientific article published on 11 March 2019

Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.

scientific article published on 02 July 2012

Role of the equilibrative and concentrative nucleoside transporters in the intestinal absorption of the nucleoside drug, ribavirin, in wild-type and Ent1(-/-) mice.

scientific article

Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study

scientific article

Sunitinib combined with pemetrexed and carboplatin in patients with advanced solid malignancies--results of a phase I dose-escalation study

scientific article

Sunitinib combined with pemetrexed and cisplatin: results of a phase I dose-escalation and pharmacokinetic study in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer and mesothelioma

scientific article published on 30 October 2012

Sunitinib in combination with gemcitabine for advanced solid tumours: a phase I dose-finding study

scientific article

Sunitinib in combination with gemcitabine plus cisplatin for advanced non-small cell lung cancer: a phase I dose-escalation study

scientific article published on 25 February 2010

Sunitinib in combination with paclitaxel plus carboplatin in patients with advanced solid tumors: phase I study results

scientific article

Sunitinib plus erlotinib for the treatment of advanced/metastatic non-small-cell lung cancer: a lead-in study

scientific article published on 01 September 2012

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