List of works by Jeffrey Milbrandt

A genetic method for defining DNA-binding domains: application to the nuclear receptor NGFI-B

scientific article published on October 1993

A human yeast artificial chromosome containing the multiple endocrine neoplasia type 2B Ret mutation does not induce medullary thyroid carcinoma but does support the growth of kidneys and partially rescues enteric nervous system development in Ret-d

scientific article

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration

scientific article

A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.

scientific article

A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene.

scientific article published on March 2000

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.

scientific article

A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles.

scientific article

A transcription factor for cold sensation!

scientific article

AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development

scientific article published on February 2009

Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy.

scientific article published on March 2013

Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion of Ctcf in Camk2a-Cre-Expressing Neurons

scientific article published on 13 November 2017

Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia

scientific article published on 21 May 2007

Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations

scientific article

Amplification of a cloned Chinese hamster dihydrofolate reductase gene after transfer into a dihydrofolate reductase-deficient cell line

scientific article

An Egr-1 master switch for arteriogenesis: studies in Egr-1 homozygous negative and wild-type animals.

scientific article

An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma

scientific article published on 07 December 2016

An in vitro assay to study induction of the regenerative state in sensory neurons

scientific article

An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury

scientific article

Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons.

scientific article

Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11

scientific journal article

Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization

scientific article

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

scientific article

Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.

scientific article

Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants

scientific article published on 27 May 2015

Characterization of the Promoter of SF-1, an Orphan Nuclear Receptor Required for Adrenal and Gonadal Development

article

Cloning of the initiation region of a mammalian chromosomal replicon.

scientific article

Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype.

scientific article published on June 2007

Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation.

scientific article

Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling

scientific article published on 01 September 2022

Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the rat

scientific article

Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems

scientific article

Differential activation of NGF receptor and early response genes in neural crest-derived cells

scientific article published on March 1, 1992

Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction

scientific article

Differential regulation of the transcriptional activity of the orphan nuclear receptor NGFI-B by membrane depolarization and nerve growth factor

scientific article published on 01 December 1997

Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element.

scientific article published on 6 October 2005

Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy

scientific article published on 23 November 2019

Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies

scientific journal article

Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development.

scientific article published in January 2003

Dynamics of neural crest-derived cell migration in the embryonic mouse gut.

scientific article published in June 2004

EGR1 target genes in prostate carcinoma cells identified by microarray analysis.

scientific article published on December 2000

EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression.

scientific article published on May 2001

Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis

scientific article

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders

scientific article published on 27 April 2015

Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse

scientific article (publication date: August 1999)

Expression profiles provide insights into early malignant potential and skeletal abnormalities in multiple endocrine neoplasia type 2B syndrome tumors.

scientific article

Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

scientific article

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

scientific article (publication date: 6 December 2002)

Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies.

scientific article

GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.

scientific article published on August 1998

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

scientific article published on 14 January 2019

Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation

scientific journal article

Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A

scientific article published on 01 April 1995

High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation

scientific article published on 04 September 2020

Homozygous deletion of early growth response 1 gene and critical limb ischemia after vascular ligation in mice: evidence for a central role in vascular homeostasis.

scientific article

Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery

scientific article (publication date: 7 September 2001)

Identifying DNA-Binding Sites and Analyzing DNA-Binding Domains Using a Yeast Selection System

Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations

scientific article published on 01 October 2002

In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter

scientific article published in April 2002

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

scientific article (publication date: 13 August 2004)

Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis

scientific article published on 16 October 2000

Lipid rafts in neuronal signaling and function.

scientific article

Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)

scientific journal article

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.

scientific article published on 17 January 2017

Measuring transcription factor binding and gene expression using barcoded self-reporting transposon calling cards and transcriptomes

scientific article published in 2022

Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule

scientific article

Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions.

scientific article

Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.

scientific article

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

scientific article

Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.

scientific article

MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes

scientific article

Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases

scientific article

Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.

scientific article

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons

scientific article

Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex

scientific article

Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration

scientific journal article

NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

scientific article

NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation.

scientific article published on 4 January 2007

NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons.

scientific article published on January 2002

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.

scientific article published on 13 October 2016

NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia.

scientific article published on 30 August 2017

Nab proteins are essential for peripheral nervous system myelination

scientific journal article

Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain

scientific article

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

scientific article

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

scientific article

Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent

scientific article

Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C ⬇️

scientific article published on May 15, 1992

Neurturin and persephin promote the survival of embryonic basal forebrain cholinergic neurons in vitro

scientific article (publication date: November 2003)

Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3

scientific article

Neurturin-Deficient Mice Develop Dry Eye and Keratoconjunctivitis Sicca ⬇️

scientific article (publication date: October 2003)

Nicotinamide adenine dinucleotide (NAD)–regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus ⬇️

scientific article published on November 24, 2010

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

scientific article published on 4 November 2011

Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide

scientific article

Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth.

scientific article

Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy

scientific article published on 06 May 2016

Novel mutants of NAB corepressors enhance activation by Egr transactivators

scientific article

Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage

scientific article published on July 1997

Organization of a Chinese hamster ovary dihydrofolate reductase gene identified by phenotypic rescue

scientific article

Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors

scientific article published on April 3, 1992

Persephin, a novel neurotrophic factor related to GDNF and neurturin

scientific article

Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor

scientific article published on 01 April 1994

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.

scientific article

Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.

scientific article published on 2 January 2013

RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice.

scientific article published on October 2006

RET signaling is required for survival and normal function of nonpeptidergic nociceptors

scientific journal article

Rapid and extraction-free detection of SARS-CoV-2 from saliva with colorimetric LAMP

scientific article published on 11 May 2020

Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.

scientific article

Resveratrol stimulates AMP kinase activity in neurons

scholarly article

Role of oxygen consumption in hypoxia protection by translation factor depletion.

scientific article published on 26 March 2013

SARM1 activation triggers axon degeneration locally via NAD⁺ destruction

scientific article

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation

scientific article published on 26 September 2016

SCG10 is a JNK target in the axonal degeneration pathway.

scientific article published on 27 November 2012

Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity.

scientific article published on September 2016

Selective contribution of Egr1 (zif/268) to persistent inflammatory pain

scientific article published on 01 January 2005

Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3

scientific article

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

scientific article

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

scientific journal article

Structure of the NGFI-A gene and detection of upstream sequences responsible for its transcriptional induction by nerve growth factor

scientific article

TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity

scientific article

TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.

scientific article published on 19 January 2018

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

scientific article

TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance

scientific article published on April 2016

TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling.

scientific article

The AMPK β2 subunit is required for energy homeostasis during metabolic stress

scientific article

The NGFI-B protein, an inducible member of the thyroid/steroid receptor family, is rapidly modified posttranslationally

scientific article published on December 1990

The Nab2 and Stat6 genes share a common transcription termination region.

scientific article

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.

scientific article published in March 2017

The Transcriptional Corepressor NAB2 Blocks Egr-1-Mediated Growth Factor Activation and Angiogenesis

article

The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response facto

scientific article published on April 1998

The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty.

scientific article

The long and short isoforms of Ret function as independent signaling complexes.

scientific article published on 28 June 2002

The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase.

scientific article published on February 1993

The purine nucleosides adenosine and guanosine delay axonal degeneration in vitro

scientific article published on 20 February 2009

The transcription factor Egr3 modulates sensory axon-myotube interactions during muscle spindle morphogenesis.

scientific article published in April 2001

The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression.

scientific article published in February 2004

The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma

scientific article

The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells

scientific article

Tissue factor expression and angiogenesis in human prostate carcinoma

scientific article published on 01 April 2000

Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor.

scientific article published on November 1993

Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

scientific article

Validation of a next-generation sequencing assay for clinical molecular oncology.

scientific article published on 6 November 2013

mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.

scientific article published on 8 May 2017

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