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List of works by Brent J Ryan

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance

scientific article published on 16 January 2017

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

scientific journal article

Autoantibodies to posttranslational modifications in rheumatoid arthritis ⬇️

scientific article published on 23 March 2014

C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function

scientific article published on 05 August 2016

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

scientific article published in June 2019

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

scientific article published on 23 December 2016

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

scientific article published on 30 September 2013

Detection and characterization of autoantibodies against modified self-proteins in SLE sera after exposure to reactive oxygen and nitrogen species.

scientific article published in January 2014

Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens

scientific article published on 12 December 2012

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

scientific article published on 17 February 2016

Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells

scientific article

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders.

scientific article published on 30 October 2017

Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation

scientific article published on 24 June 2020

Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease.

scientific article published on October 2011

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells

scientific article published on 07 October 2018

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

scientific article

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function

scientific article published in 2022

Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase

scientific article published on 15 June 2018

Oxidative and other posttranslational modifications in extracellular vesicle biology

scientific article published on 24 February 2015

Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases.

scientific article

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

scientific article published on 05 July 2019

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers

scientific article published on 14 November 2014

Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation

scientific article published on 21 August 2019

Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease

scientific article published on 26 November 2015

REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model

scientific article published on 09 February 2021

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse

scientific article published on 10 October 2013

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

scientific article published on 29 November 2018

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease

scientific article published on 19 October 2013

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