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List of works by Lawrence M Pfeffer

20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes

scientific article

48 Assay of the inhibitory activities of human interferons on the proliferation and locomotion of fibroblasts

scientific article published on 01 January 1981

A Type I Interferon Signaling Factor, ISF21, Encoded on Chromosome 21 Is Distinct from Receptor Components and Their Down-regulation and Is Necessary for Transcriptional Activation of Interferon-regulated Genes

article

APELA Expression in Glioma, and Its Association with Patient Survival and Tumor Grade

scientific article published on 26 March 2019

Activation of chemokine and inflammatory cytokine response in hepatitis C virus–infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates ⬇️

scientific article published on January 30, 2012

Adiponectin and its receptors in chronic hepatitis B patients with metabolic syndrome in China.

scientific article

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention

scientific article published on January 2013

An interferon response gene signature is associated with the therapeutic response of hepatitis C patients

scientific article

Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy.

scientific article published on 27 April 2017

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion

scientific article published on 01 October 2018

Beta-interferon-induced time-dependent changes in the plasma membrane lipid bilayer of cultured cells

scientific article published on 01 January 1981

Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes

scientific article published on September 2008

Bortezomib sensitizes human glioblastoma cells to induction of apoptosis by type I interferons through NOXA expression and Mcl-1 cleavage

scientific article published on 19 July 2016

CRH inhibits NF-kappa B signaling in human melanocytes.

scientific article published on 7 September 2006

Characterization of interferon-alpha binding sites on human cell lines

scientific article published on 01 December 1988

Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells

scientific article published on 12 November 2018

Chromenes: potential new chemotherapeutic agents for cancer.

scientific article

Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships.

scientific article published on 12 June 2006

Comparison of the effects of alpha and beta interferons on the proliferation and volume of human tumor cells (HeLa-S3, Daudi, P3HR-1)

scientific article published on 01 January 1983

Comprehensive analysis of microRNA (miRNA) targets in breast cancer cells

scientific article published on 06 August 2013

Conference report. International Society for Interferon and Cytokine Research

scientific article published on 01 September 2000

Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway.

scientific article published on 31 July 2013

Continuous delivery of IFN-beta promotes sustained maturation of intratumoral vasculature.

scientific article

Continuous local delivery of interferon-β stabilizes tumor vasculature in an orthotopic glioblastoma xenograft resection model

scientific article

Correction: Molecular Heterogeneity in a Patient-Derived Glioblastoma Xenoline is Regulated by Different Cancer Stem Cell Populations

scientific article published on 10 December 2015

Correction: Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression

scientific article published on 01 November 2019

Corticotropin-releasing hormone inhibits nuclear factor-kappaB pathway in human HaCaT keratinocytes.

scientific article

DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion

scientific article

Defective expression of high affinity IL-2 receptors on activated T cells from aged humans

scientific article published on 01 January 1990

Design, Synthesis and Biological Evaluation of Novel 5H-Chromenopyridines as Potential Anti-Cancer Agents.

scientific article published on 17 September 2015

Detection of Exosomal miRNAs in the Plasma of Melanoma Patients

scientific article

DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice

scientific article

Differences in Activity between α and β Type I Interferons Explored by Mutational Analysis

scientific article published in Journal of Biological Chemistry

Differential genetic susceptibility of cultured human skin fibroblasts to transformation by Kirsten murine sarcoma virus ⬇️

scientific article published on February 1, 1977

Do second messengers play a role in interferon signal transduction?

scientific article published on September 1991

EDL-360: A Potential Novel Antiglioma Agent.

scientific article

Effects of beta interferon on concanavalin A binding and size of HeLa cells.

scientific article published in January 1982

Effects of beta interferon on human fibroblasts at different population doubling levels. Proliferation, cell volume, thymidine uptake, and DNA synthesis.

scientific article published on June 1984

Expression of the IFN alpha receptor in hairy cell leukaemia

scientific article published on 01 November 1992

Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race

scientific article published in August 2006

Growth abnormalities of cultured human skin fibroblasts derived from individuals with hereditary adenomatosis of the colon and rectum

scientific article published on September 1, 1976

Human renal cancers resistant to IFN's antiproliferative action exhibit sensitivity to IFN's gene-inducing and antiviral actions

scientific article published on 01 November 1996

IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis.

scientific article

IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression.

scientific article

Identification of CXCL11 as a STAT3-dependent gene induced by IFN.

scientific article published on January 2007

Identification of imidazoquinoline derivatives as potent antiglioma agents

scientific article

Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer

scientific article

Inhibition of type I interferon-mediated antiviral action in human glioma cells by the IKK inhibitors BMS-345541 and TPCA-1.

scientific article

Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway

scientific article

Interferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcript

scientific article

Interferon effects on microfilament organization cellular fibronectin distribution, and cell motility in human fibroblasts ⬇️

scientific article published on April 1, 1980

Interferon effects on the growth and division of human fibroblasts

scientific article published on June 1, 1979

Interferon increases the abundance of submembranous microfilaments in HeLa-S3 cells in suspension culture ⬇️

scientific article published on October 1, 1981

Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival

scientific article

Interferon induces the interaction of prothymosin-alpha with STAT3 and results in the nuclear translocation of the complex.

scientific article published in August 2004

Interferon inhibition of thymidine incorporation into DNA through effects on thymidine transport and uptake

scientific article published on 01 November 1984

Interferon inhibits the redistribution of cell surface components.

scientific article

Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization.

scientific article

Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis

scientific article

Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells

scientific article published on April 1, 1992

Interferon-resistant Daudi cell line with a Stat2 defect is resistant to apoptosis induced by chemotherapeutic agents

scientific article

Interferons in 1995

scientific article published on 01 June 1996

Isolation of circulating microRNAs from microvesicles found in human plasma.

scientific article

KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells

scientific article published on 15 June 2015

KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells.

scientific article published on 17 January 2017

Knockout of MTF1 Inhibits the Epithelial to Mesenchymal Transition in Ovarian Cancer Cells

scientific article published on 11 November 2018

Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells.

scientific article published on January 2017

Lentiviral Vector Mediated Claudin1 Silencing Inhibits Epithelial to Mesenchymal Transition in Breast Cancer Cells

scientific article published on 10 June 2015

Lentiviral vector mediated-ASAP1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells.

scientific article published on 22 January 2018

Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition.

scientific article published on 28 January 2012

MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity.

scientific article

MiRNA203 suppresses the expression of protumorigenic STAT1 in glioblastoma to inhibit tumorigenesis

scientific article published on 02 October 2016

MicroRNA miR-21 Regulates the Metastatic Behavior of B16 Melanoma Cells ⬇️

scientific article published on September 22, 2011

MicroRNA regulation of F-box proteins and its role in cancer.

scientific article published on 30 September 2015

MicroRNA-1 suppresses glioblastoma in preclinical models by targeting fibronectin

scientific article published on 03 September 2019

MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers

scientific article published on 28 July 2014

MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3).

scientific article

MicroRNA203a suppresses glioma tumorigenesis through an ATM-dependent interferon response pathway.

scientific article published on 6 December 2017

Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries

scientific article

Molecular heterogeneity in a patient-derived glioblastoma xenoline is regulated by different cancer stem cell populations

scientific article published on 8 May 2015

NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity.

scientific article published on 03 March 2006

Non-conventional signal transduction by type 1 interferons: the NF-kappaB pathway

scientific article published on December 2007

Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

scientific article published on 26 December 2016

Novel approaches to glioma drug design and drug screening.

scientific article published on 06 June 2013

Oral cancer: enduring characteristics and emerging trends.

scientific article published on January 2011

Oral cancer: enduring characteristics and emerging trends.

scientific article published on February 2012

Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer

scientific article published on 03 September 2019

Ovarian Primary and Metastatic Tumors Suppressed by Survivin Knockout or a Novel Survivin Inhibitor

scientific article published on 12 September 2019

Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells.

scientific article

Polymorphism of endogenous murine leukemia viruses revealed by isoelectric focusing in polyacrylamide gels ⬇️

scientific article published on October 1, 1976

Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma

scientific article

Recombinant vesicular stomatitis virus vectors as oncolytic agents in the treatment of high-grade gliomas in an organotypic brain tissue slice-glioma coculture model.

scientific article published in June 2004

Retracted: Curcumin Potentiates Rhabdomyosarcoma Radiosensitivity by Suppressing NF-κB Activity

retracted article

Review of recent developments in the molecular characterization of recombinant alfa interferons on the 40th anniversary of the discovery of interferon.

scientific article

Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex.

scientific article published on September 1994

Role of nuclear factor-kappaB in the antiviral action of interferon and interferon-regulated gene expression.

scientific article

Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo.

scientific article published on 28 August 2007

SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway

scientific article

STAT3 complements defects in an interferon-resistant cell line: Evidence for an essential role for STAT3 in interferon signaling and biological activities ⬇️

scientific article published on May 12, 1998

Segregation of Histone Fractions from Purified Rat Pancreas Nuclei by Isoelectric Focusing ⬇️

scientific article published on 01 February 1976

Selective interferon-alpha/beta effects on platelet-derived growth factor-stimulated processes in quiescent BALB/c-3T3 fibroblasts.

scientific article published on October 1994

Silencing the double-stranded RNA binding protein DGCR8 inhibits ovarian cancer cell proliferation, migration, and invasion.

scientific article published on March 2015

Structure of the human interferon alpha receptor.

scientific article published on November 1991

Systematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer.

scientific article

The Role of Nuclear Factor κB in the Interferon Response ⬇️

scientific article published on June 1, 2011

The Role of miR-21 in Cancer

scientific article published on 16 June 2015

The STAT3 and hypoxia pathways converge on Vasorin to promote stemness and glioblastoma tumorigenesis through Notch1 stabilization

scientific article published on 22 October 2018

The Type I IFN-Induced miRNA, miR-21

scientific article

The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma.

scientific article published on 24 April 2018

The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo

scientific article

The effects of type I interferon on glioblastoma cancer stem cells.

scientific article

The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein

scientific article

The oncogenic microRNA-21 inhibits the tumor suppressive activity of FBXO11 to promote tumorigenesis

scientific article

The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response

scientific article published on 24 March 2008

The role of TRAF2 binding to the type I interferon receptor in alternative NFκB activation and antiviral response. VOLUME 283 (2008) PAGES 14309-14316.

scientific article published in December 2008

The role of constitutively activated STAT3 in B16 melanoma cells ⬇️

scientific article published on January 1, 2010

Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells ⬇️

scientific article published on September 15, 1991

Transmembrane signalling by interferon-alpha.

scientific article

Tumor necrosis factor induces phosphorylation of a 28-kDa mRNA cap-binding protein in human cervical carcinoma cells.

scientific article

Unphosphorylated STAT3 regulates the antiproliferative, antiviral, and gene-inducing actions of type I interferons

scientific article

Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression

scientific article published on 08 February 2019

Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent

scientific article

Withdrawal: DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion

scientific article published on 01 November 2019

Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition

scientific article published on 11 September 2020

miR-203 Functions as a Tumor Suppressor by Inhibiting Epithelial to Mesenchymal Transition in Ovarian Cancer

scientific article

miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFβ pathway

scientific article published on 21 September 2018

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