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List of works by Dena Lyras

A dynamic, ring-forming MucB / RseB-like protein influences spore shape in Bacillus subtilis

scientific article published on 14 December 2020

A mouse model of Staphylococcus aureus small intestinal infection

scientific article published on 31 January 2020

A series of three cases of severe Clostridium difficile infection in Australia associated with a binary toxin producing clade 2 ribotype 251 strain

scientific article published on 27 November 2018

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

scientific article published on 25 May 2015

Antibacterial activity of rhodomyrtone on Clostridium difficile vegetative cells and spores in vitro

scientific article published on 24 August 2018

Antibiotic resistance, virulence factors and genetics of Clostridium sordellii

scientific article published on 05 October 2014

Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria.

scientific article published on 22 April 2015

Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative

scientific article published on 16 June 2017

CYP101J2, CYP101J3, and CYP101J4, 1,8-Cineole-Hydroxylating Cytochrome P450 Monooxygenases from Sphingobium yanoikuyae Strain B2.

scientific article published on 02 September 2016

CdtR Regulates TcdA and TcdB Production in Clostridium difficile

scientific article

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

scientific article published on 12 August 2019

Characterization of a Tra 2 function of RP1 that affects growth of Pseudomonas aeruginosa PAO and surface exclusion in Escherichia coli K12

scientific article published on 01 March 1992

Characterization of the ends and target sites of the novel conjugative transposon Tn5397 from Clostridium difficile: excision and circularization is mediated by the large resolvase, TndX.

scientific article

Chloramphenicol-resistant Neisseria meningitidis containing catP isolated in Australia.

scientific article published on 16 October 2003

Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

scientific article published on 20 March 2020

Clostridium difficile drug pipeline: challenges in discovery and development of new agents

scientific article published on 30 March 2015

Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis

scientific article published on 03 December 2018

Clostridium perfringens-mediated necrotic enteritis is not influenced by the pre-existing microbiota but is promoted by large changes in the post-challenge microbiota

scientific article published on 01 November 2018

Clostridium sordellii Pathogenicity Locus Plasmid pCS1-1 Encodes a Novel Clostridial Conjugation Locus

scientific article published on 16 January 2018

Clostridium sordellii genome analysis reveals plasmid localized toxin genes encoded within pathogenicity loci

scientific article published on 16 May 2015

Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract.

scientific article published on 18 April 2018

Comparing the identification of Clostridium spp. by two Matrix-Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) mass spectrometry platforms to 16S rRNA PCR sequencing as a reference standard: a detailed analysis of age of culture and

Conjugation-mediated horizontal gene transfer of Clostridium perfringens plasmids in the chicken gastrointestinal tract results in the formation of new virulent strains.

scientific article published on 13 October 2017

Conjugative transfer of RP4-oriT shuttle vectors from Escherichia coli to Clostridium perfringens.

scientific article published in January 1998

Construction and analysis of chromosomal Clostridium difficile mutants

scientific article published on September 2006

Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene.

scientific article published on 20 January 2009

Crystal structure of a β-aminopeptidase from an Australian Burkholderia sp.

scientific article published on 17 June 2017

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

scientific article published on 2 June 2015

Disruption of the Gut Microbiome: Clostridium difficile Infection and the Threat of Antibiotic Resistance

scientific article

Diverse bacterial species contribute to antibiotic-associated diarrhoea and gastrointestinal damage

scientific article published on 30 June 2018

Emergence of a ribotype 244 strain of Clostridium difficile associated with severe disease and related to the epidemic ribotype 027 strain

scientific article published on 4 April 2014

Emergence of toxin A-negative, toxin B-positive Clostridium difficile strains: epidemiological and clinical considerations.

scientific article published in January 2015

Environmental response and autoregulation of Clostridium difficile TxeR, a sigma factor for toxin gene expression.

scientific article

Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals

scientific article

Evidence that compatibility of closely related replicons in Clostridium perfringens depends on linkage to parMRC-like partitioning systems of different subfamilies

scientific article published on 5 April 2017

Expansion of the Clostridium perfringens toxin-based typing scheme

scientific article published on 20 April 2018

Expression of the large clostridial toxins is controlled by conserved regulatory mechanisms

scientific article published on 18 August 2014

Extrachromosomal and integrated genetic elements in Clostridium difficile.

scientific article published on 27 April 2015

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. ⬇️

scientific article

Functional analysis of an feoB mutant in Clostridium perfringens strain 13.

scientific article published on 10 May 2016

Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens

scientific article

Genomic analysis of the erythromycin resistance element Tn5398 from Clostridium difficile.

scientific article published in October 2001

Genomic diversity of necrotic enteritis-associated strains of Clostridium perfringens: a review

scientific article published on 7 March 2016

Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens

scientific article

Identification of large cryptic plasmids in Clostridioides (Clostridium) difficile.

scientific article

Identification of the structural and functional domains of the large serine recombinase TnpX from Clostridium perfringens

scientific article published on 12 November 2004

In silico, in vitro and in vivo analysis of putative virulence factors identified in large clostridial toxin-negative, binary toxin- producing C. difficile strains

scientific article published on 01 August 2019

Induction of pCW3-encoded tetracycline resistance in Clostridium perfringens involves a host-encoded factor.

scientific article published in November 2001

Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens

scientific article

International Society for Plasmid Biology.

scientific article published in July 2015

Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131.

scientific article

Involvement of Bacteria Other Than Clostridium difficile in Antibiotic-Associated Diarrhoea.

scientific article published on 17 February 2016

Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile

scientific article published on 21 February 2019

Methods for Determining Transfer of Mobile Genetic Elements in Clostridium difficile

scientific article published on January 2016

Methods for Gene Cloning and Targeted Mutagenesis

article

Molecular characterization and antimicrobial susceptibilities of Clostridium difficile clinical isolates from Victoria, Australia

scientific article

Necrotic Enteritis in Chickens Associated with Clostridium sordellii

scientific article published on September 2015

Novel molecular type of Clostridium difficile in neonatal pigs, Western Australia

scientific article published on May 2013

Novel use of tryptose sulfite cycloserine egg yolk agar for isolation of Clostridium perfringens during an outbreak of necrotizing enterocolitis in a neonatal unit

scientific article

Opioid analgesics stop the development of clostridial gas gangrene

scientific article

Options for improving effectiveness of rotavirus vaccines in developing countries.

scientific article

Paeniclostridium sordellii and Clostridioides difficile encode similar and clinically relevant tetracycline resistance loci in diverse genomic locations

scientific article published on 04 March 2019

Plasmid partitioning systems of conjugative plasmids from Clostridium perfringens.

scientific article published on 27 April 2015

Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis.

scientific article

Preface: ClostPath 2013 meeting on The Molecular Biology and Pathogenesis of the Clostridia special issue

scientific article published on 01 December 2014

Regulation of toxin production in the pathogenic clostridia.

scientific article published on January 2014

Reply to: Caution is warranted in using cephamycin antibiotics against recurrent Clostridioides difficile infection

scientific article published on 27 January 2020

Small animal models for the study of Clostridium difficile disease pathogenesis.

scientific article published on 07 January 2014

Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX.

scientific article published on 26 February 2015

Spo0A differentially regulates toxin production in evolutionarily diverse strains of Clostridium difficile

scientific article

Structural Characterization of Clostridium sordellii Spores of Diverse Human, Animal, and Environmental Origin and Comparison to Clostridium difficile Spores.

scientific article published on September 2017

Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics

scientific article published on 9 September 2015

TcdB or not TcdB: a tale of two Clostridium difficile toxins.

scientific article published in February 2011

TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens

scientific article

TcsL is an essential virulence factor in Clostridium sordellii ATCC 9714

scientific article

The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.

scientific article published on January 1994

The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence

scientific article published on 03 August 2009

The Sialidase NanS Enhances Non-TcsL Mediated Cytotoxicity of Clostridium sordellii

scientific article published on 17 June 2016

The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile

scientific article

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

scientific article

The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria

scientific article

The cysteine protease α-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis.

scientific article

The large resolvase TnpX is the only transposon-encoded protein required for transposition of the Tn4451/3 family of integrative mobilizable elements.

scientific article published in March 2004

The macrolide-lincosamide-streptogramin B resistance determinant from Clostridium difficile 630 contains two erm(B) genes

scientific article

The peptidoglycan hydrolase TcpG is required for efficient conjugative transfer of pCW3 in Clostridium perfringens.

scientific article

The pore-forming α-toxin from clostridium septicum activates the MAPK pathway in a Ras-c-Raf-dependent and independent manner

scientific article

The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives.

scientific article

The α-toxin ofClostridium septicumis essential for virulence

article

Toxin B is essential for virulence of Clostridium difficile

scientific article

Transcriptional analysis of the tet(P) operon from Clostridium perfringens.

scientific article

Translocation and dissemination of commensal bacteria in post-stroke infection.

scientific article

Two distinct regions of the large serine recombinase TnpX are required for DNA binding and biological function

scientific article published in 2006

Utility of the clostridial site-specific recombinase TnpX to clone toxic-product-encoding genes and selectively remove genomic DNA fragments

scientific article

Whole genome analysis reveals the diversity and evolutionary relationships between necrotic enteritis-causing strains of Clostridium perfringens.

scientific article

X-ray crystal structure of cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae strain B2.

scientific article

tISCpe8, an IS1595-family lincomycin resistance element located on a conjugative plasmid in Clostridium perfringens.

scientific article published on 14 August 2009

β-Aminopeptidases: Insight into Enzymes without a Known Natural Substrate

scientific article published on 18 July 2019

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