List of works by Dario DiFrancesco

A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins.

scientific article

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia.

scientific article

A new interpretation of the pace-maker current in calf Purkinje fibres ⬇️

scientific article published on 01 May 1981

A study of the ionic nature of the pace-maker current in calf Purkinje fibres ⬇️

scientific article published on 01 May 1981

Acetylcholine inhibits activation of the cardiac hyperpolarizing-activated current, if.

scientific article

Action of internal pronase on the f-channel kinetics in the rabbit SA node.

scientific article published on November 1999

Action of ouabain, oligomycin, and glucagon on cultured heart cells treated with adriamycin

scientific article published on 01 February 1976

Activation of f‐channels by cAMP analogues in macropatches from rabbit sino‐atrial node myocytes ⬇️

scientific article published on June 15, 1997

Activation of the hyperpolarization-activated current (if) in sino-atrial node myocytes of the rabbit by vasoactive intestinal peptide

scientific article published on 01 March 1996

An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation

scientific article published on 18 June 2012

Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways

scientific article

Autonomic modulation of heart rate: pitfalls of nonselective channel blockade

scientific article published on 01 December 2003

Barium-induced blockade of the inward rectifier in calf Purkinje fibres

scientific article published on 01 December 1984

Block and activation of the pace-maker channel in calf Purkinje fibres: effects of potassium, caesium and rubidium ⬇️

scientific article published on 01 August 1982

Block of the cardiac pacemaker current (If) in the rabbit sino-atrial node and in canine Purkinje fibres by 9-amino-1,2,3,4-tetrahydroacridine

scientific article published in February 1991

C terminus-mediated control of voltage and cAMP gating of hyperpolarization-activated cyclic nucleotide-gated channels.

scientific article published on 7 June 2001

Cardiac mesoangioblasts are committed, self-renewable progenitors, associated with small vessels of juvenile mouse ventricle.

scientific article published on 23 May 2008

Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking

scientific article published on 21 December 2015

Cesium and the pacemaker current.

scientific article published in December 1995

Characterization of single pacemaker channels in cardiac sino-atrial node cells

scientific article published in Nature

Characterization of the pace-maker current kinetics in calf Purkinje fibres ⬇️

scientific article published on March 1, 1984

Comparing pathways for long-term heart rate modulation by the funny current

scientific article published on 20 August 2019

Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If "funny" current.

scientific article published on 18 January 2016

Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine

scientific article

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness ⬇️

scientific article

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

scientific article

Delayed activation of the cardiac pacemaker current and its dependence on conditioning pre-hyperpolarizations

scientific article published on 01 March 1983

Differential effects of ACh on cardiac pacemaker cells

scientific article published on July 1, 1992

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.

scientific article

Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node.

scientific article published on 24 April 2009

Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node.

scientific article published in March 1999

Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f) ⬇️

scientific article published on January 1, 1991

Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells.

scientific article published on 10 June 2013

Erratum: Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness

scholarly article published in Nature Chemical Biology

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

scientific article

Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel

scientific article

Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors.

scientific article published in July 2002

Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells

scientific article (publication date: August 2002)

Funny channel gene mutations associated with arrhythmias

scientific article

Funny channels in the control of cardiac rhythm and mode of action of selective blockers.

scientific article

Generation and control of cardiac pacing the pacemaker current

scientific article published on 01 September 1991

HCN4, Sinus Bradycardia and Atrial Fibrillation

scientific article published on 15 March 2015

Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.

scientific article published in January 2004

Heart rate reduction via selective 'funny' channel blockers.

scientific article published on 30 January 2007

Higher cardiogenic potential of iPSCs derived from cardiac versus skin stromal cells

scientific article published in January 2016

How does adrenaline accelerate the heart? ⬇️

scientific article published on July 19, 1979

Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin

scientific article published on 10 September 2010

Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process.

scientific article published on 25 February 2011

Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current I(f).

scientific article published on 27 April 2001

Identification of the molecular site of ivabradine binding to HCN4 channels

scientific article (publication date: 2013)

In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors

scientific article

Inhibition of the hyperpolarization-activated current (if) of rabbit SA node myocytes by niflumic acid

scientific article published on 01 March 1996

Interaction of the pacemaker channel HCN1 with filamin A.

scientific article

Intracellular Ca modulates K-inward rectification in cardiac myocytes

scientific article published on 01 January 1989

Intracellular calcium does not directly modulate cardiac pacemaker (if) channels

scientific article published on 01 December 1991

LEONARDO DA VINCI AND THE ORIGIN OF SEMEN

scientific article

Letter regarding article by Michels et al, "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias"

scientific article published on 01 August 2005

Mammalian γ2 AMPK regulates intrinsic heart rate

scientific article

Measurement and significance of the reversal potential for the pace-maker current (iK2) in sheep Purkinje fibres ⬇️

scientific article published on 01 December 1979

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

scientific article

Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current

scientific article published on 06 May 2007

Modulation of single hyperpolarization-activated channels (i(f)) by cAMP in the rabbit sino-atrial node

scientific article published on 01 February 1994

Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker

scientific article published on 16 March 2009

Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.

scientific article published on 11 December 2008

More seafood to control heart rate?

scientific article published on 21 August 2009

Multifactorial impact of channel beta-subunit gene mutation on automaticity

scientific article published on 09 September 2013

Multinucleated giant cells with an osteoclast phenotype derived from caprine peripheral blood mononuclear cells.

scientific article published on 6 September 2010

Muscarinic control of the hyperpolarization-activated current (if) in rabbit sino-atrial node myocytes

scientific article published on 01 November 1988

Muscarinic modulation of cardiac rate at low acetylcholine concentrations

scientific article published on 01 February 1989

Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function.

scientific article

Pacemaker channels.

scientific article published on May 2004

Pacemaker mechanisms in cardiac tissue.

scientific article

Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.

scientific article

Reciprocal role of the inward currents ib, Na and i(f) in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells

scientific article published on December 22, 1992

Separation of current induced by potassium accumulation from acetylcholine-induced relaxation current in the rabbit S-A node

scientific article published on 01 September 1980

Serious workings of the funny current.

scientific article

Single-channel properties of the sinoatrial node Na+ current in the newborn rabbit.

scientific article

Some properties of the UL-FS 49 block of the hyperpolarization-activated current (i(f)) in sino-atrial node myocytes.

scientific article

Structural determinants of ivabradine block of the open pore of HCN4

The 'funny' side of sepsis.

scientific article published on March 2014

The contribution of potassium accumulation to outward currents in frog atrium

scientific article published on 01 September 1980

The effects of manganese and barium on the cardiac pacemaker current, if, in rabbit sino-atrial node myocytes

scholarly article by Dario DiFrancesco et al published 1 May 1991 in Experientia

The funny current: cellular basis for the control of heart rate.

scientific article published on January 2007

The human gene coding for HCN2, a pacemaker channel of the heart

scientific article (publication date: 3 September 1999)

The pacemaker current (If) plays an important role in regulating SA node pacemaker activity ⬇️

scientific article published on 01 August 1995

The pacemaker current: from basics to the clinics.

scientific article published on 30 January 2007

The role of the funny current in pacemaker activity.

scientific article

The short N-terminus is required for functional expression of the virus-encoded miniature K(+) channel Kcv.

scientific article published on October 2002

The time course of potassium current following potassium accumulation in frog atrium: analytical solutions using a linear approximation.

scientific article published in September 1980

The viral potassium channel Kcv: structural and functional features.

scientific article published in September 2003

Two distinct pathways of muscarinic current responses in rabbit sino-atrial node myocytes

scientific article published on 01 December 1998

Voltage-dependence of virus-encoded miniature K+ channel Kcv.

scientific article published on May 2002

Voltage‐clamp investigations of membrane currents underlying pace‐maker activity in rabbit sino‐atrial node ⬇️

scientific article published on November 1, 1980

beta-modulation of pacemaker rate: novel mechanism or novel mechanics of an old one?

scientific article

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