List of works - Richard Gray

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

scientific article published on November 2017

5'fluorouracil (FU) and folinic acid (FA) in either the weekly 'Roswell Park' or the 4-weekly 'Mayo' regimen should be standard chemotherapy for colon cancer.

scientific article published in September 2003

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

article

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

article

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

article

A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: the ECLIPSE trial.

scientific article published in October 2015

Accuracy of radiological staging in identifying high-risk colon cancer patients suitable for neoadjuvant chemotherapy: a multicentre experience.

scientific article published in April 2012

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials ⬇️

scientific article

Adjuvant bisphosphonates in early breast cancer: consensus guidance for clinical practice from a European Panel

scientific article published on 17 December 2015

Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials

scientific article published on January 2008

Adjuvant chemotherapy plus tamoxifen compared with tamoxifen alone for postmenopausal breast cancer: meta-analysis of quality-adjusted survival

scientific article

Adjuvant chemotherapy with 5-fluorouracil, L-folinic acid and levamisole for patients with colorectal cancer: non-randomised comparison of weekly versus four-weekly schedules--less pain, same gain. QUASAR Colorectal Cancer Study Group

scientific article published on 01 August 2000

Adjuvant tamoxifen: how long before we know how long? ⬇️

scientific article published on May 16, 1998

Adjuvant treatment for colorectal cancer. Concerns about chemotherapy are legitimate.

scientific article published in June 1996

Adjuvant treatment with tamoxifen. Recruitment into studies assessing optimum duration of treatment must continue.

scientific article published in April 1996

Alcohol and coronary heart disease reduction among British doctors: confounding or causality?

scientific article published on 01 January 1997

Anal fistula plug versus surgeon's preference for surgery for trans-sphincteric anal fistula: the FIAT RCT

scientific article published on 01 May 2019

Antipsychotic treatment of very late-onset schizophrenia-like psychosis (ATLAS): a randomised, controlled, double-blind trial.

scientific article

Anything in modulation?

scientific article published in September 2003

Autografting for patients with CML in chronic phase: an update. Hammersmith BMT Team LRF Centre for Adult Leukaemia

scientific article published on 01 January 1994

Balancing treatment allocations by clinician or center in randomized trials allows unacceptable levels of treatment prediction.

scientific article

Breast-Cancer Recurrence after Stopping Endocrine Therapy

scientific article published on 01 March 2018

Combination chemotherapy for myelomatosis

scientific article published on 01 August 1992

Commentary: Mendelian randomization--an update on its use to evaluate allogeneic stem cell transplantation in leukaemia

scientific article published on 01 February 2004

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

scientific article published on 16 December 2007

Continuous versus interrupted perineal repair with standard or rapidly absorbed sutures after spontaneous vaginal birth: a randomised controlled trial

scientific article published on 01 June 2002

DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT

scientific article published on 24 July 2009

Determining the minimum clinically important differences for outcomes in the DOMINO trial.

scientific article published on 16 September 2010

Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials

scientific article

Does telecare prolong community living in dementia? A study protocol for a pragmatic, randomised controlled trial.

scientific article

Donepezil and memantine for moderate-to-severe Alzheimer's disease.

scientific article

Dopamine agonist therapy in early Parkinson's disease

scientific article

Dose intensification in acute myeloid leukaemia: greater effectiveness at lower cost. Principal report of the Medical Research Council's AML9 study. MRC Leukaemia in Adults Working Party

scientific article published on 01 July 1996

Effectiveness of rivastigmine in Alzheimer's disease. Improvements in functional ability remain unestablished

scientific article

Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial

scientific article published on 12 September 2017

Efficacy of intraportal infusion for colon cancer: a fair assessment?

scientific article published on 01 May 1991

Erratum to “Choices of Stent and Cerebral Protection in the Ongoing ACST-2 Trial: A Descriptive Study” [Eur J Vasc Endovasc Surg 53 (2017) 617–625]

scholarly article published in European Journal of Vascular and Endovascular Surgery

Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials

scientific article

Evaluation of the efficacy and safety of adjunct treatment to levodopa therapy in Parkinson's disease patients with motor complications

scientific article (published 2008-04-23)

Factors predisposing women to chronic pelvic pain: systematic review

scientific article published on 16 February 2006

HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials ⬇️

scientific article published on 22 December 2015

Hysterectomy, endometrial ablation and Mirena® for heavy menstrual bleeding: a systematic review of clinical effectiveness and cost-effectiveness analysis

scientific article published on April 2011

Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding: systematic review and meta-analysis of data from individual patients

scientific article

ICON4/AGO-OVAR-2.2: questions about trial design, cost-effectiveness, and clinical benefit

Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain.

scientific article

Influence of more extensive radiotherapy and adjuvant chemotherapy on long-term outcome of early-stage Hodgkin's disease: a meta-analysis of 23 randomized trials involving 3,888 patients. International Hodgkin's Disease Collaborative Group.

scientific article

Innovative estimation of survival using log-normal survival modelling on ACCENT database.

scientific article published on 5 February 2013

Intra-tumoural stromal morphometry predicts disease recurrence but not response to 5-fluorouracil - results from the QUASAR trial of colorectal cancer. ⬇️

scientific article

Intraportal 5-fluorouracil for colorectal cancer: the AXIS trial

scientific article published on 01 October 1992

Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial

scientific article published in September 2009

Large-scale randomized evidence: large, simple trials and overviews of trials.

scientific article published on January 1995

Levonorgestrel intrauterine system versus medical therapy for menorrhagia

scientific article published in January 2013

Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial

scientific article published on 11 June 2014

Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial

scientific article published on March 2013

Making randomised trials larger: a simple solution?

scientific article published in April 1995

Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukemia: results of the United Kingdom Medical Research Council's 10th AML trial. MRC Childhood Leukaemia Working Party.

scientific article published in April 1998

Meta-analysis using individual patient data from randomised trials to assess the effectiveness of laparoscopic uterosacral nerve ablation in the treatment of chronic pelvic pain: a proposed protocol.

scientific article

Monoamine oxidase type B inhibitors in early Parkinson's disease: meta-analysis of 17 randomised trials involving 3525 patients

scientific article

Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors.

scientific article published on October 1994

Mortality in relation to smoking: 22 years' observations on female British doctors

scientific article published on 01 April 1980

Mortality in relation to smoking: 40 years' observations on male British doctors

scientific article

Multiple sclerosis risk sharing scheme: two year results of clinical cohort study with historical comparator

scientific article (publication date: 2 December 2009)

National study of colorectal cancer genetics

scientific article published on 25 September 2007

Neoadjuvant chemotherapy for early breast cancer - Author's reply

scientific article published on 01 March 2018

PLUTO trial protocol: percutaneous shunting for lower urinary tract obstruction randomised controlled trial

scientific article published in July 2007

Prognostic importance of Sudan Black positivity: a study of bone marrow slides from 1386 patients with de novo acute myeloid leukaemia ⬇️

scientific article published on November 1, 1991

Prophylactic Low-Dose Oxygen for Patients With Acute Stroke-Reply.

scientific article published in February 2018

Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial. UK Medical Research Council Adult and Children's Leukaemia Working Par

scientific article

Rapid testing for group B streptococcus during labour: a test accuracy study with evaluation of acceptability and cost-effectiveness

scientific article (publication date: September 2009)

Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

article

Revascularization versus medical therapy for renal-artery stenosis

scientific article

Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT.

scientific article published in March 2018

Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives

scientific article published on 25 September 2006

Statistical analysis plan for the Stroke Oxygen Study (SO₂S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome

scientific article

Surgery for Parkinson's disease: lack of reliable clinical trial evidence.

scientific article

Systematic review and meta-analysis of randomized clinical trials of self-expanding metallic stents as a bridge to surgery versus emergency surgery for malignant left-sided large bowel obstruction (Br J Surg 2012; 99: 469-476)

scientific article published on 01 October 2012

Tamoxifen for early breast cancer: better late than never

scientific article published on 01 May 2000

Tamoxifen therapy for patients with breast cancer - Authors' reply.

scientific article published in June 2013

Tamoxifen: how boldly to go where no women have gone before

scientific article published on 01 September 1993

The EBCTCG overview of adjuvant therapy of breast cancer. What are the implications for future studies? Early Breast Cancer Trialists' Collaborative Group.

scientific article

The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial

scientific article published on 31 March 2014

The optimal duration of adjuvant tamoxifen treatment for breast cancer remains uncertain: randomize into aTTom

scientific article published on 01 January 1997

The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Results from 20 years of prospective observation

scientific article published on 01 September 1983

Time to initiation of adjuvant chemotherapy and survival in colorectal cancer

Tumour site, sex, and survival in colorectal cancer

Validation study of a quantitative multigene reverse transcriptase-polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer

scientific article published on 7 November 2011

Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer

scientific article published on 7 March 2011

Variation in practice of laparoscopic uterosacral nerve ablation: a European survey

scientific article published on 01 August 2004

List of works by Richard Gray

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

5'fluorouracil (FU) and folinic acid (FA) in either the weekly 'Roswell Park' or the 4-weekly 'Mayo' regimen should be standard chemotherapy for colon cancer.

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: the ECLIPSE trial.

Accuracy of radiological staging in identifying high-risk colon cancer patients suitable for neoadjuvant chemotherapy: a multicentre experience.

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials ⬇️

Adjuvant bisphosphonates in early breast cancer: consensus guidance for clinical practice from a European Panel

Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials

Adjuvant chemotherapy plus tamoxifen compared with tamoxifen alone for postmenopausal breast cancer: meta-analysis of quality-adjusted survival

Adjuvant chemotherapy with 5-fluorouracil, L-folinic acid and levamisole for patients with colorectal cancer: non-randomised comparison of weekly versus four-weekly schedules--less pain, same gain. QUASAR Colorectal Cancer Study Group

Adjuvant tamoxifen: how long before we know how long? ⬇️

Adjuvant treatment for colorectal cancer. Concerns about chemotherapy are legitimate.

Adjuvant treatment with tamoxifen. Recruitment into studies assessing optimum duration of treatment must continue.

Alcohol and coronary heart disease reduction among British doctors: confounding or causality?

Anal fistula plug versus surgeon's preference for surgery for trans-sphincteric anal fistula: the FIAT RCT

Antipsychotic treatment of very late-onset schizophrenia-like psychosis (ATLAS): a randomised, controlled, double-blind trial.

Anything in modulation?

Autografting for patients with CML in chronic phase: an update. Hammersmith BMT Team LRF Centre for Adult Leukaemia

Balancing treatment allocations by clinician or center in randomized trials allows unacceptable levels of treatment prediction.

Breast-Cancer Recurrence after Stopping Endocrine Therapy

Combination chemotherapy for myelomatosis

Commentary: Mendelian randomization--an update on its use to evaluate allogeneic stem cell transplantation in leukaemia

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

Continuous versus interrupted perineal repair with standard or rapidly absorbed sutures after spontaneous vaginal birth: a randomised controlled trial

DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT

Determining the minimum clinically important differences for outcomes in the DOMINO trial.

Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials

Does telecare prolong community living in dementia? A study protocol for a pragmatic, randomised controlled trial.

Donepezil and memantine for moderate-to-severe Alzheimer's disease.

Dopamine agonist therapy in early Parkinson's disease

Dose intensification in acute myeloid leukaemia: greater effectiveness at lower cost. Principal report of the Medical Research Council's AML9 study. MRC Leukaemia in Adults Working Party

Effectiveness of rivastigmine in Alzheimer's disease. Improvements in functional ability remain unestablished

Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial

Efficacy of intraportal infusion for colon cancer: a fair assessment?

Erratum to “Choices of Stent and Cerebral Protection in the Ongoing ACST-2 Trial: A Descriptive Study” [Eur J Vasc Endovasc Surg 53 (2017) 617–625]

Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials

Evaluation of the efficacy and safety of adjunct treatment to levodopa therapy in Parkinson's disease patients with motor complications

Factors predisposing women to chronic pelvic pain: systematic review

HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials ⬇️

Hysterectomy, endometrial ablation and Mirena® for heavy menstrual bleeding: a systematic review of clinical effectiveness and cost-effectiveness analysis

Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding: systematic review and meta-analysis of data from individual patients

ICON4/AGO-OVAR-2.2: questions about trial design, cost-effectiveness, and clinical benefit

Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain.

Influence of more extensive radiotherapy and adjuvant chemotherapy on long-term outcome of early-stage Hodgkin's disease: a meta-analysis of 23 randomized trials involving 3,888 patients. International Hodgkin's Disease Collaborative Group.

Innovative estimation of survival using log-normal survival modelling on ACCENT database.

Intra-tumoural stromal morphometry predicts disease recurrence but not response to 5-fluorouracil - results from the QUASAR trial of colorectal cancer. ⬇️

Intraportal 5-fluorouracil for colorectal cancer: the AXIS trial

Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial

Large-scale randomized evidence: large, simple trials and overviews of trials.

Levonorgestrel intrauterine system versus medical therapy for menorrhagia

Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial

Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial

Making randomised trials larger: a simple solution?

Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukemia: results of the United Kingdom Medical Research Council's 10th AML trial. MRC Childhood Leukaemia Working Party.

Meta-analysis using individual patient data from randomised trials to assess the effectiveness of laparoscopic uterosacral nerve ablation in the treatment of chronic pelvic pain: a proposed protocol.

Monoamine oxidase type B inhibitors in early Parkinson's disease: meta-analysis of 17 randomised trials involving 3525 patients

Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors.

Mortality in relation to smoking: 22 years' observations on female British doctors

Mortality in relation to smoking: 40 years' observations on male British doctors

Multiple sclerosis risk sharing scheme: two year results of clinical cohort study with historical comparator

National study of colorectal cancer genetics

Neoadjuvant chemotherapy for early breast cancer - Author's reply

PLUTO trial protocol: percutaneous shunting for lower urinary tract obstruction randomised controlled trial

Prognostic importance of Sudan Black positivity: a study of bone marrow slides from 1386 patients with de novo acute myeloid leukaemia ⬇️

Prophylactic Low-Dose Oxygen for Patients With Acute Stroke-Reply.

Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial. UK Medical Research Council Adult and Children's Leukaemia Working Par

Rapid testing for group B streptococcus during labour: a test accuracy study with evaluation of acceptability and cost-effectiveness

Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

Revascularization versus medical therapy for renal-artery stenosis

Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT.

Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives

Statistical analysis plan for the Stroke Oxygen Study (SO₂S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome

Surgery for Parkinson's disease: lack of reliable clinical trial evidence.

Systematic review and meta-analysis of randomized clinical trials of self-expanding metallic stents as a bridge to surgery versus emergency surgery for malignant left-sided large bowel obstruction (Br J Surg 2012; 99: 469-476)

Tamoxifen for early breast cancer: better late than never

Tamoxifen therapy for patients with breast cancer - Authors' reply.

Tamoxifen: how boldly to go where no women have gone before