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List of works by Adam Zlotnick

A Molecular Breadboard: Removal and Replacement of Subunits in an Hepatitis B Virus Capsid

scientific article published on 10 August 2017

A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly

scientific article

A kinase chaperones hepatitis B virus capsid assembly and captures capsid dynamics in vitro

scientific article

A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly

scientific article

A quantitative description of in vitro assembly of human papillomavirus 16 virus-like particles

scientific article published on 5 June 2008

A reaction landscape identifies the intermediates critical for self-assembly of virus capsids and other polyhedral structures

scientific article published on June 2005

A simple and general method for determining the protein and nucleic acid content of viruses by UV absorbance

scientific article

A small molecule inhibits and misdirects assembly of hepatitis B virus capsids

scientific article published on May 2002

All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits.

scientific article published on 27 April 2018

Altering the Energy Landscape of Virus Self-Assembly to Generate Kinetically Trapped Nanoparticles

An Assembly-Activating Site in the Hepatitis B Virus Capsid Protein Can Also Trigger Disassembly

scientific article published on 06 July 2018

An Overview of Capsid Assembly Kinetics

An alpha-helical peptide model for electrostatic interactions of proteins with DNA

article

An in vitro fluorescence screen to identify antivirals that disrupt hepatitis B virus capsid assembly

scientific article published on 12 February 2006

Analysis of the nucleotide sequence of bean pod mottle virus middle component RNA.

scientific article published on July 1991

Analytical Techniques to Characterize the Structure, Properties, and Assembly of Virus Capsids

scientific article published on 03 December 2018

Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).

scientific article

Are weak protein–protein interactions the general rule in capsid assembly? ⬇️

scientific article published on October 25, 2003

Assembly Properties of Hepatitis B Virus Core Protein Mutants Correlate with Their Resistance to Assembly-Directed Antivirals

scholarly article by Lu Ruan published in October 2018

Assembly Reactions of Hepatitis B Capsid Protein into Capsid Nanoparticles Follow a Narrow Path through a Complex Reaction Landscape

scientific article published on 25 June 2019

Assembly and Release of Hepatitis B Virus

scientific article

Assembly-Directed Antivirals Differentially Bind Quasiequivalent Pockets to Modify Hepatitis B Virus Capsid Tertiary and Quaternary Structure

scientific article

Asymmetric Modification of Hepatitis B Virus (HBV) Genomes by an Endogenous Cytidine Deaminase inside HBV Cores Informs a Model of Reverse Transcription.

scientific article

BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly

scientific article published in November 2006

Characterization of Virus Capsids and Their Assembly Intermediates by Multi-Cycle Resistive-Pulse Sensing with Four Pores in Series.

scientific article

Characterization of hepatitis B virus capsids by resistive-pulse sensing

scientific article published on 25 January 2011

Charge Detection Mass Spectrometry Identifies Preferred Non-Icosahedral Polymorphs in the Self-Assembly of Woodchuck Hepatitis Virus Capsids.

scientific article

Competition between Normative and Drug-Induced Virus Self-Assembly Observed with Single-Particle Methods

scientific article published on 31 December 2018

Conformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus Assembly

scientific article

Conformational equilibria and rates of localized motion within hepatitis B virus capsids

scientific article

Core protein: A pleiotropic keystone in the HBV lifecycle

scientific article published on 27 June 2015

Designing two self-assembly mechanisms into one viral capsid protein

scientific article

Detection of late intermediates in virus capsid assembly by charge detection mass spectrometry

scientific article published on 19 February 2014

Differential assembly of Hepatitis B Virus core protein on single- and double-stranded nucleic acid suggest the dsDNA-filled core is spring-loaded.

scientific article published on 16 May 2012

Distinguishing reversible from irreversible virus capsid assembly

scientific article published on 11 November 2006

Editorial overview: Virus structure and assembly: Virions - from structure and physics to design principles

scientific article published in June 2016

Effects of the cowpea chlorotic mottle bromovirus beta-hexamer structure on virion assembly

scientific article published on February 2003

Encapsidated hepatitis B virus reverse transcriptase is poised on an ordered RNA lattice

scientific article

Evolution of Intermediates during Capsid Assembly of Hepatitis B Virus with Phenylpropenamide-Based Antivirals

scientific article published on 04 February 2019

Exploring the paths of (virus) assembly

scientific article

Full-length hepatitis B virus core protein packages viral and heterologous RNA with similarly high levels of cooperativity

scientific article

Genetically altering the thermodynamics and kinetics of hepatitis B virus capsid assembly has profound effects on virus replication in cell culture

scientific article

Geometric Defects and Icosahedral Viruses

scientific article published on 4 January 2018

Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1.

scientific article

HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly ⬇️

scientific article published on 19 June 2017

Hepatitis B Virus Capsid Completion Occurs through Error Correction.

scientific article published on 10 November 2017

Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket

scientific article published on 3 February 2016

Hepatitis B Virus Core Protein Phosphorylation Sites Affect Capsid Stability and Transient Exposure of the C-terminal Domain

scientific article

Hepatitis B virus capsid assembly is enhanced by naturally occurring mutation F97L.

scientific article

Hepatitis B virus capsid: localization of the putative immunodominant loop (residues 78 to 83) on the capsid surface, and implications for the distinction between c and e-antigens.

scientific article published on June 1998

Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids.

scientific article published on 29 January 2018

Hepatitis virus capsid polymorph stability depends on encapsulated cargo size

scientific article published on 30 September 2013

Higher Resolution Charge Detection Mass Spectrometry

scientific article published on 03 August 2020

How does your virus grow? Understanding and interfering with virus assembly

scientific article published on December 2003

Importin β Can Bind Hepatitis B Virus Core Protein and Empty Core-Like Particles and Induce Structural Changes

scientific article

In vitro assembly of an empty picornavirus capsid follows a dodecahedral path.

scientific article published on 26 September 2012

In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions)

scientific article

In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides

scientific article published in Science

Interaction with capsid protein alters RNA structure and the pathway for in vitro assembly of cowpea chlorotic mottle virus

scientific article published in January 2004

Length of encapsidated cargo impacts stability and structure of in vitro assembled Alphavirus core-like particles

scientific article published on 4 October 2017

Localization of the C terminus of the assembly domain of hepatitis B virus capsid protein: implications for morphogenesis and organization of encapsidated RNA.

scientific article published on September 1997

Localization of the N terminus of hepatitis B virus capsid protein by peptide-based difference mapping from cryoelectron microscopy.

scientific article published on December 1998

Macromolecular Crystallography for Synthetic Abiological Molecules: Combining xMDFF and PHENIX for Structure Determination of Cyanostar Macrocycles

scientific article published on 29 June 2015

Model-based analysis of assembly kinetics for virus capsids or other spherical polymers

scientific article

Molecular jenga: the percolation phase transition (collapse) in virus capsids

Monitoring Assembly of Virus Capsids with Nanofluidic Devices

scientific article published on 12 August 2015

Multiple Pathways in Capsid Assembly

scientific article published on 19 April 2018

Nanofluidic Devices with 8 Pores in Series for Real-Time, Resistive-Pulse Analysis of Hepatitis B Virus Capsid Assembly.

scientific article published on 21 March 2017

Nanofluidic devices with two pores in series for resistive-pulse sensing of single virus capsids

scientific article published on 11 November 2011

Observed hysteresis of virus capsid disassembly is implicit in kinetic models of assembly

scientific article published on 13 March 2003

One protein, at least three structures, and many functions

scientific article published on January 2013

Pathogens use structural mimicry of native host ligands as a mechanism for host receptor engagement

scientific article published on July 2013

Phase diagrams map the properties of antiviral agents directed against hepatitis B virus core assembly

scientific article published on 3 December 2012

Phosphorylation of the Brome Mosaic Virus Capsid Regulates the Timing of Viral Infection

scientific article published on 22 June 2016

Quantitative analysis of multi-component spherical virus assembly: scaffolding protein contributes to the global stability of phage P22 procapsids

scientific article

RNA encapsidation by SV40-derived nanoparticles follows a rapid two-state mechanism

scientific article

Redirecting the coat protein of a spherical virus to assemble into tubular nanostructures

scientific article published in March 2006

Regulating Self-Assembly of Spherical Oligomers

scientific article published on 01 April 2005

Resolution of space-group ambiguity and structure determination of nodamura virus to 3.3 A resolution from pseudo-R32 (monoclinic) crystals.

scientific article published in November 1997

Revealing in real-time a multistep assembly mechanism for SV40 virus-like particles

scientific article published on 15 April 2020

Scaffold properties are a key determinant of the size and shape of self-assembled virus-derived particles

scientific article published on 23 October 2013

Self-Assembly of an Alphavirus Core-like Particle Is Distinguished by Strong Intersubunit Association Energy and Structural Defects.

scientific article published on 14 August 2015

Shared motifs of the capsid proteins of hepadnaviruses and retroviruses suggest a common evolutionary origin.

scientific article

Simple Models and Simple Analyses of Virus Capsid Assembly

scholarly article published 2005

Single Particle Observation of SV40 VP1 Polyanion-Induced Assembly Shows That Substrate Size and Structure Modulate Capsid Geometry

scientific article

Single-particle electrophoresis in nanochannels

scientific article

Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle

scientific article published on 6 August 2008

Structural Differences Between the Woodchuck Hepatitis Virus Core Protein in Dimer and Capsid States Indicate Entropic and Conformational Regulation of Assembly

Structural Differences between the Woodchuck Hepatitis Virus Core Protein in the Dimer and Capsid States Are Consistent with Entropic and Conformational Regulation of Assembly

scientific article published on 28 June 2019

Structural organization of pregenomic RNA and the carboxy-terminal domain of the capsid protein of hepatitis B virus

scientific article

Structurally similar woodchuck and human hepadnavirus core proteins have distinctly different temperature dependences of assembly.

scientific article published on 24 September 2014

Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors

scientific article published on 12 December 2016

The Structural Biology of Hepatitis B Virus: Form and Function

scientific article

The energetic contributions of scaffolding and coat proteins to the assembly of bacteriophage procapsids

scientific article published on 20 April 2012

The extracellular domain of immunodeficiency virus gp41 protein: expression in Escherichia coli, purification, and crystallization.

scientific article

The hepatitis B virus core protein intradimer interface modulates capsid assembly and stability

scientific article

The interface between hepatitis B virus capsid proteins affects self-assembly, pregenomic RNA packaging, and reverse transcription

scientific article published on 7 January 2015

The role of subunit hinges and molecular “switches” in the control of viral capsid polymorphism

article

The thermodynamics of virus capsid assembly

scientific article

Theoretical aspects of virus capsid assembly

scientific article

To build a virus on a nucleic acid substrate.

scientific article published on April 2013

Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS2 hydrolase.

scientific article published on September 2014

Trapping of hepatitis B virus capsid assembly intermediates by phenylpropenamide assembly accelerators

scientific article

Uncatalyzed assembly of spherical particles from SV40 VP1 pentamers and linear dsDNA incorporates both low and high cooperativity elements

Use of a Fluorescent Analogue of a HBV Core Protein-Directed Drug To Interrogate an Antiviral Mechanism

scientific article published on 30 October 2018

Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3.

scientific article

Virus assembly, allostery and antivirals

scientific article published on 14 December 2010

Viruses and the physics of soft condensed matter

scholarly article

Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy.

scientific article published on March 1997

Weak protein-protein interactions are sufficient to drive assembly of hepatitis B virus capsids

scientific article published in October 2002

Zinc ions trigger conformational change and oligomerization of hepatitis B virus capsid protein

scientific article published in August 2004

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