List of works - C Wolf

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

scientific article published on September 2008

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

scientific article published on 10 October 2013

A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

scientific article

A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor

scientific article published on 12 December 2013

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

scientific article

Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.

scientific article published on May 2004

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

scientific article published in July 1996

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

scientific article published on 01 March 2009

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

scientific article published on 8 November 2016

Alterations in rat hepatic drug metabolism during pregnancy and lactation

scientific article published on 01 July 1993

Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.

scientific article published on 26 August 2015

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

scientific article

Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

scientific article published on 18 October 2016

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

scientific article published in February 2015

Aryl hydrocarbon receptor is required for optimal B-cell proliferation.

scientific article

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

scientific article published on June 2016

Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.

scientific article

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

scientific article published on 01 February 2006

Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo

scientific article published on 21 March 2012

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

scientific article published on 13 April 2007

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.

scientific article

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

scientific article published on 16 September 2016

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity

scientific article

Cytochrome P450 CYP2D6.

scientific article

Cytochrome P450s and chemoprevention

scientific article published on 01 February 2000

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

scientific article published on 14 February 2014

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

scientific article published on 5 February 2015

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

scientific article published on 11 August 2015

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

scientific article published on 19 September 2008

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

scientific article published on 26 March 2014

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

scientific article (publication date: October 2001)

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity ⬇️

scientific article published on May 1, 1998

Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples

scientific article published on 18 July 2007

Disruption of the glutathione transferase pi class genes.

scientific article

Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.

scientific article published on 31 January 2008

Engineering of a functional human NADH-dependent cytochrome P450 system

scientific article

Epigenetic profiles as defined signatures of xenobiotic exposure

scientific article published on 31 August 2013

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.

scientific article published on 17 February 2015

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

scientific article

Expression of P450 isoenzymes during rat liver organogenesis

scientific article published on 01 November 1993

Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability

scientific article

Generation and utility of genetically humanized mouse models.

scientific article

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

scientific article published on November 2006

Genetic polymorphisms in xenobiotic metabolism.

scientific article published on January 1994

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

scientific article

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

scientific article published on 09 January 2012

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

scientific article

Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

scientific article published in October 2007

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

scientific article

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.

scientific article published on 2 February 2006

High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

scientific article published on 01 January 1993

Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)

scientific article published on February 1993

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

scientific article published on 19 April 2010

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

scientific article

Illuminating Role of CYP1A1 in Skin Function

scientific article published on 10 January 2008

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

scientific article published on 13 January 2006

In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.

scientific article

In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

scientific article

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

scientific article

Increased skin papilloma formation in mice lacking glutathione transferase GSTP.

scientific article published on 5 October 2011

Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

scientific article

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

scientific article

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

scientific article published in February 2003

Knockout mice in xenobiotic metabolism

scientific article published in November 2003

Lactational transfer of 2,4,5,2',4',5'-hexachlorobiphenyl but not 3,4,3',4'-tetrachlorobiphenyl, induces neonatal CYP4A1

scientific article published on 01 February 1993

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

scientific article

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

scientific article

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

scientific article

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy.

scientific article published on 4 October 2007

Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review

scientific article published on 21 October 2009

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

scientific article

Metabolic polymorphisms and cancer susceptibility.

scientific article published on January 1995

Metabolism of [3-14C] coumarin by human liver microsomes

scientific article published on 01 August 1994

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms

scientific article published on April 2015

Molecular genetics of the human cytochrome P450-dependent monooxygenases.

scientific article published in October 1992

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

scientific article published on 21 July 2008

Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

scientific article

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

scientific article

Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse.

scientific article published on 07 September 2016

Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

article

Perspective on the application of pharmacogenomics in the treatment of cancer.

scientific article published in April 2009

Pharmacogenetics

scientific article published on 01 January 1999

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

scientific article published on June 2004

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors

scientific article published on April 2014

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.

scientific article published on 25 May 2014

Pi-class glutathione S-transferase: regulation and function.

scientific article published on April 1998

Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

scientific article published on 5 February 2008

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.

scientific article published on January 2003

Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk.

scientific article published in May 2010

Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.

scientific article published in April 2003

Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver.

scientific article published on 20 April 2015

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours ⬇️

scientific article published on June 28, 2011

Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line

scientific article published on 31 May 2011

Quantitative real-time reverse transcription-polymerase chain reaction analysis of drug metabolizing and cytoprotective genes in psoriasis and regulation by ultraviolet radiation.

scientific article published in August 2003

Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo.

scientific article

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

scientific article

Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse

scientific article published on 01 May 2005

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

scientific article published on 26 September 2007

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant

scientific article

Science, medicine, and the future: Pharmacogenetics

scientific article

Spatial monitoring of toxicity in HMOX-LacZ transgenic mice.

scientific article published on 14 January 2010

Spatial p21 expression profile in the mid-term mouse embryo.

scientific article published on 28 March 2010

Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease.

scientific article

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

scientific article (publication date: February 2000)

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

scientific article published on 15 December 2005

The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s

scientific article published on 09 May 2011

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.

scientific article published on 20 April 2005

The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells ⬇️

scientific article published on November 15, 2011

The usage of a three-compartment model to investigate the metabolic differences between hepatic reductase null and wild-type mice.

scientific article published on 5 October 2015

Transfer of PCBs via lactation simultaneously induces the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf in neonates

scientific article published on 01 February 1996

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.

scientific article published on January 2009

Use of transgenic animals in understanding molecular mechanisms of toxicity.

scientific article

Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition

article

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

scientific article

p21-LacZ reporter mice reflect p53-dependent toxic insult

article

List of works by C Wolf

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

Alterations in rat hepatic drug metabolism during pregnancy and lactation

Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

Aryl hydrocarbon receptor is required for optimal B-cell proliferation.

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity

Cytochrome P450 CYP2D6.

Cytochrome P450s and chemoprevention

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity ⬇️

Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples

Disruption of the glutathione transferase pi class genes.

Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.

Engineering of a functional human NADH-dependent cytochrome P450 system

Epigenetic profiles as defined signatures of xenobiotic exposure

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

Expression of P450 isoenzymes during rat liver organogenesis

Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability

Generation and utility of genetically humanized mouse models.

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

Genetic polymorphisms in xenobiotic metabolism.

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.

High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

Illuminating Role of CYP1A1 in Skin Function

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.

In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Increased skin papilloma formation in mice lacking glutathione transferase GSTP.

Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

Knockout mice in xenobiotic metabolism

Lactational transfer of 2,4,5,2',4',5'-hexachlorobiphenyl but not 3,4,3',4'-tetrachlorobiphenyl, induces neonatal CYP4A1

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy.

Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

Metabolic polymorphisms and cancer susceptibility.

Metabolism of [3-14C] coumarin by human liver microsomes

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms

Molecular genetics of the human cytochrome P450-dependent monooxygenases.

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse.