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List of works by Srinivasan Madhusudan

5-Carboxylcytosine levels are elevated in human breast cancers and gliomas

scientific article published on 21 August 2015

A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene.

scientific article published on May 2004

A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer.

scientific article published on October 2003

A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer.

scientific article published on October 2004

A prospective randomised phase II trial of thalidomide with carboplatin compared with carboplatin alone as a first-line therapy in women with ovarian cancer, with evaluation of potential surrogate markers of angiogenesis

scientific article published on 01 January 2011

ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

scientific article published on 18 October 2019

Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications.

scientific article published on 31 March 2010

Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers

scientific article

Analysis of lymphatic and blood vessel invasion biomarkers in T1 esophagogastric adenocarcinomas for improved patient prognostication.

scientific article published on 24 February 2014

Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?

scientific article

Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells

scientific article

Base excision repair factors are promising prognostic and predictive markers in cancer.

scientific article published on January 2012

Bcl2 is an independent prognostic marker of triple negative breast cancer (TNBC) and predicts response to anthracycline combination (ATC) chemotherapy (CT) in adjuvant and neoadjuvant settings

scientific article published in August 2013

Biological and clinical significance of PARP1 protein expression in breast cancer

scientific article

Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla ⬇️

scientific article published on November 9, 2012

Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer

scientific article published on 03 March 2016

Cancer pharmacogenomics: role of DNA repair genetic polymorphisms in individualizing cancer therapy.

scientific article published on January 2007

Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy.

scientific article published in April 2012

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial

scientific article

Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair.

scientific article published on July 2011

Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response

scientific article published on 17 February 2015

Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer

scientific article published on 3 October 2015

Circulating biomarkers during treatment in patients with advanced biliary tract cancer receiving cediranib in the UK ABC-03 trial

scientific article published on 21 June 2018

Clinical Impact of Tumor DNA Repair Expression and T-cell Infiltration in Breast Cancers

scientific article published on 2 March 2017

Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein

scientific article

Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers

scientific article published on 11 November 2016

Clinicopathological and functional significance of XRCC1 expression in ovarian cancer

scientific article published on 27 December 2012

Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.

scientific article

Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.

scientific article

Clinicopathological significance of KU70/KU80, a key DNA damage repair protein in breast cancer

scientific article published on 28 April 2013

Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers

scientific article published on 12 February 2019

Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer

scientific article published on 01 January 2014

Current status of excision repair cross complementing-group 1 (ERCC1) in cancer.

scientific article published on 17 August 2007

DNA Repair Endonucleases: Physiological Roles and Potential as Drug Targets.

scientific article published on 15 April 2015

DNA damage repair in breast cancer and its therapeutic implications

scientific article published on 26 December 2016

DNA polymerase β deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts

scientific article published on 10 January 2014

DNA repair in cancer: emerging targets for personalized therapy.

scientific article published on 19 February 2014

DNA repair inhibition: a selective tumour targeting strategy.

scientific article

DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers

scientific article

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

scientific article

Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era.

scientific article

Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial

scientific article

Dysregulation of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in advanced retinoblastoma

scientific article published on 2 January 2014

ERCC1 Is a Predictor of Anthracycline Resistance and Taxane Sensitivity in Early Stage or Locally Advanced Breast Cancers

scientific article published on 10 August 2019

ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers

scientific article published on 21 February 2019

Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma.

scientific article published in May 2003

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer.

scientific article published on 13 November 2017

Evolving drug targets in DNA base excision repair for cancer therapy

scientific article published on 01 January 2012

Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.

scientific article published on 19 January 2013

Feasibility of Intravenous Iron Isomaltoside to Improve Anemia and Quality of Life During Palliative Chemotherapy for Esophagogastric Adenocarcinoma

scientific article published on 10 September 2018

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

scientific article published on 19 June 2014

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

scientific article

HER-2/Neu overexpression is a rare event in peri-ampullary cancer: assessment using the HercepTest.

scientific article

Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer.

scientific article published on 06 January 2010

Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway.

scientific article published on 24 March 2016

Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.

scientific article

Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study

scientific article

Intrahepatic sarcomatoid cholangiocarcinoma.

scientific article published on 29 April 2010

Intraperitoneal gene therapy.

scientific article published on January 2007

Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?

scientific article

Is there a role for second-line platinum re-challenge in advanced biliary tract cancers?

scientific article published on 10 June 2014

Isolation of a small molecule inhibitor of DNA base excision repair.

scientific article

KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer

scientific article

LY2495655, an antimyostatin antibody, in pancreatic cancer: a randomized, phase 2 trial

scientific article published on 27 July 2018

MAGIC in practice: experience of peri-operative ECF/X chemotherapy in gastro-esophageal adenocarcinomas.

scientific article published on 4 June 2012

MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours.

scientific article published on 08 March 2016

Monoclonal Antibodies Targeting LecLex-Related Glycans with Potent Antitumor Activity.

scientific article

Oncogenic osteomalacia and metastatic breast cancer: a case report and review of the literature

scientific article published on 22 March 2019

PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers

scientific article published on 24 October 2019

Pharmacokinetically guided phase I trial of topotecan and etoposide phosphate in recurrent ovarian cancer

scientific article

Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma.

scientific article published on February 2005

Phase II trial of the antiangiogenic agent IM862 in metastatic renal cell carcinoma

scientific article published on November 2004

Postoperative survival following perioperative MAGIC versus neoadjuvant OE02-type chemotherapy in oesophageal adenocarcinoma

scientific article published on May 2017

Primary Esophagogastric Neuroendocrine Carcinoma: a Retrospective Study from the Nottingham Upper Gastrointestinal Cancer Center.

scientific article published on 11 December 2017

Purification and specific assays for measuring APE-1 endonuclease activity.

scientific article

Quality of life, long-term survivors and long-term outcome from the ABC-02 study

scientific article published on April 2016

RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers

scientific article published on 30 December 2020

RECQL4 helicase has oncogenic potential in sporadic breast cancers

scientific article published on 22 December 2015

Reply, Letter to the Editor - The impact of sarcopenia and myosteatosis on outcomes of unresectable pancreatic cancer or distal cholangiocarcinoma

SUMOylation proteins in breast cancer

scientific article published on March 2014

Screening for malnutrition: implications for upper gastrointestinal cancer services

scientific article published on 01 October 2010

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy

scientific article

Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer

scientific article

Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors

scientific article published on 28 March 2012

Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy

scientific article published on 27 August 2014

Targeting XRCC1 deficiency in breast cancer for personalized therapy.

scientific article published on 19 December 2012

Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy

scientific article

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy ⬇️

scientific article

The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells

scientific article published on 4 March 2013

The impact of sarcopenia and myosteatosis on outcomes of unresectable pancreatic cancer or distal cholangiocarcinoma

scientific article published in September 2015

The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays.

scientific article

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response

scientific article published on 29 June 2018

The role of adjuvant platinum-based chemotherapy in esophagogastric cancer patients who received neoadjuvant chemotherapy prior to definitive surgery.

scientific article published on 2 March 2017

Thioredoxin interacting protein and its association with clinical outcome in gastro-oesophageal adenocarcinoma

scientific article published on 23 May 2013

Transcriptomic and Protein Expression Analysis Reveals Clinicopathological Significance of Bloom Syndrome Helicase (BLM) in Breast Cancer.

scientific article

Transcriptomic profiling of Forkhead box transcription factors in adult glioblastoma multiforme

scientific article published on May 2015

Tumour regression grade (TRG) analyses in patients with resectable gastro-oesophageal adenocarcinomas treated with platinum-based neoadjuvant chemotherapy.

scientific article published on October 2009

Tyrosine kinase inhibitors and cancer therapy.

scientific article published on January 2007

Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer

scientific article

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers

scientific article published on 15 November 2021

Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial.

scientific article

Venous thromboembolism in patients receiving perioperative chemotherapy for esophagogastric cancer ⬇️

scientific article published on 07 May 2013

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