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List of works by Simon J Crabb

A phase I clinical trial of irinotecan and carboplatin in patients with extensive stage small cell lung cancer.

scientific article published on 15 August 2012

A phase Ib study investigating the combination of everolimus and dovitinib in vascular endothelial growth factor refractory clear cell renal cancer

scientific article

A randomized, double-blind phase II study evaluating cediranib versus cediranib and saracatinib in patients with relapsed metastatic clear-cell renal cancer (COSAK).

scientific article published on 22 January 2016

Advances in advanced prostate cancer - the continuing journey

scientific article published on 04 November 2015

An Oncofetal Glycosaminoglycan Modification Provides Therapeutic Access to Cisplatin-resistant Bladder Cancer

scientific article published on 10 April 2017

An indirect comparison of the toxicity of sunitinib and pazopanib in metastatic clear cell renal cancer ⬇️

scientific article published on July 4, 2012

Association Between Early PSA Increase and Clinical Outcome in Patients Treated with Enzalutamide for Metastatic Castration Resistant Prostate Cancer

scientific article

BAG-1 in carcinogenesis.

scientific article published on 22 March 2004

BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells.

scientific article published on March 2008

Basal breast cancer molecular subtype predicts for lower incidence of axillary lymph node metastases in primary breast cancer.

scientific article published on June 2008

Bone Metastases as the Only Metastatic Site in Patients With Urothelial Carcinoma: Focus on a Special Patient Population.

scientific article published in November 2017

COAST (Cisplatin ototoxicity attenuated by aspirin trial): A phase II double-blind, randomised controlled trial to establish if aspirin reduces cisplatin induced hearing-loss ⬇️

scientific article

Can clinically relevant prognostic subsets of breast cancer patients with four or more involved axillary lymph nodes be identified through immunohistochemical biomarkers? A tissue microarray feasibility study

scientific article published on 14 January 2008

Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.

scientific article

Chemotherapy at First Diagnosis of Advanced Prostate Cancer - Revolution or Evolution? Findings from a British Uro-oncology Group UK Survey to Evaluate Oncologists' Views on First-line Docetaxel in Combination with Androgen Deprivation Therapy in Ca

scientific article published on 10 February 2016

Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial

scientific article published on 04 November 2019

Clinical outcomes following neoadjuvant cisplatin-based chemotherapy for bladder cancer in elderly compared with younger patients

scientific article published on 25 January 2015

Conditional survival of patients treated with first-line chemotherapy for metastatic urothelial cancer

scientific article published on 24 October 2014

Corrigendum to 'EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort Under the Auspices of the EAU-ESMO Guidelines Committees' [European Urology 77 (2020) 223-2

scientific article published on 20 May 2020

Divergent Biological Response to Neoadjuvant Chemotherapy in Muscle-invasive Bladder Cancer

scientific article published on 17 September 2018

EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort†: Under the Auspices of the EAU-ESMO Guidelines Committees

scientific article published on 19 November 2019

EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees†

scientific article published on 01 November 2019

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

scientific article published on 13 February 2011

Epidermal Growth Factor Receptor Family Inhibition Identifies P38 Mitogen-activated Protein Kinase as a Potential Therapeutic Target in Bladder Cancer.

scientific article published on 15 November 2017

Epigenetic modulators as therapeutic targets in prostate cancer

scientific article

Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery.

scientific article published on December 2009

From Clinical Trials to Real-life Clinical Practice: The Role of Immunotherapy with PD-1/PD-L1 Inhibitors in Advanced Urothelial Carcinoma

scientific article published on 02 July 2018

High Neutrophil-to-lymphocyte Ratio Persistent During First-line Chemotherapy Predicts Poor Clinical Outcome in Patients with Advanced Urothelial Cancer

scientific article published on 19 September 2014

IMA901, a multipeptide cancer vaccine, plus sunitinib versus sunitinib alone, as first-line therapy for advanced or metastatic renal cell carcinoma (IMPRINT): a multicentre, open-label, randomised, controlled, phase 3 trial.

scientific article published on 3 October 2016

Impact of contemporary patterns of chemotherapy utilization on survival in patients with advanced cancer of the urinary tract: A Retrospective International Study of Invasive/advanced cancer of the urothelium (RISC).

scientific article published on 25 October 2017

Impact of the Number of Cycles of Platinum Based First Line Chemotherapy for Advanced Urothelial Carcinoma

scientific article published on 04 September 2018

Incidence, Patterns, and Outcomes with Adjuvant Chemotherapy for Residual Disease After Neoadjuvant Chemotherapy in Muscle-invasive Urinary Tract Cancers

scientific article published on 30 January 2019

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.

scientific article

Lipid metabolite peaks in pattern recognition analysis of tumour in vivo MR spectra

scientific article published on 01 May 1996

Long non-coding RNAs identify a subset of luminal muscle-invasive bladder cancer patients with favorable prognosis

scientific article published on 17 October 2019

Loss of expression of the tumour suppressor geneAIMP3predicts survival following radiotherapy in muscle-invasive bladder cancer

article

Nomogram-based Prediction of Overall Survival in Patients with Metastatic Urothelial Carcinoma Receiving First-line Platinum-based Chemotherapy: Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC).

scientific article

Orteronel Switch Maintenance Therapy in Metastatic Castration Resistant Prostate Cancer After First-Line Docetaxel: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (SAKK 08/11).

scientific article published on 25 July 2016

Persistent Neutrophil to Lymphocyte Ratio >3 during Treatment with Enzalutamide and Clinical Outcome in Patients with Castration-Resistant Prostate Cancer.

scientific article

Personalised Medicine for Advanced Urothelial Cancer: What is the Right Way to Identify the Right Patient for the Right Treatment?

scientific article published on 28 March 2019

Phase III, Double-Blind, Randomized Trial That Compared Maintenance Lapatinib Versus Placebo After First-Line Chemotherapy in Patients With Human Epidermal Growth Factor Receptor 1/2-Positive Metastatic Bladder Cancer.

scientific article

Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group

scientific article published on 11 October 2007

ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer

scientific article

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

scientific article

Publisher Correction: Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial

scientific article published on 01 June 2020

Radical cystectomy or bladder preservation with radiochemotherapy in elderly patients with muscle-invasive bladder cancer: Retrospective International Study of Cancers of the Urothelial Tract (RISC) Investigators

scientific article

Radiological Response Heterogeneity Is of Prognostic Significance in Metastatic Renal Cell Carcinoma Treated with Vascular Endothelial Growth Factor-targeted Therapy

scientific article published on 06 February 2019

Randomized Phase II Study Investigating Pazopanib Versus Weekly Paclitaxel in Relapsed or Progressive Urothelial Cancer.

scientific article published on 12 April 2017

Real-World Data on Cabozantinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma: Focus on Sequences and Prognostic Factors

scientific article published on 30 December 2019

Robot-assisted Versus Open Radical Cystectomy in Patients Receiving Perioperative Chemotherapy for Muscle-invasive Bladder Cancer: The Oncologist's Perspective from a Multicentre Study.

scientific article

S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition.

scientific article published on 17 June 2010

SPIRE - combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer: study protocol for a phase Ib/randomised IIa open label clinical trial.

scientific article published on 3 April 2018

SUCCINCT: an open-label, single-arm, non-randomised, phase 2 trial of gemcitabine and cisplatin chemotherapy in combination with sunitinib as first-line treatment for patients with advanced urothelial carcinoma

scientific article published on 20 November 2014

Safety and Efficacy of Pazopanib Therapy Prior to Planned Nephrectomy in Metastatic Clear Cell Renal Cancer.

scientific article published on 2 June 2016

Serum total hCGβ level is an independent prognostic factor in transitional cell carcinoma of the urothelial tract.

scientific article published on 20 February 2014

Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis

scientific article

Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib

scientific article published on 09 July 2016

The Impact of Cisplatin- or Non-Cisplatin-Containing Chemotherapy on Long-Term and Conditional Survival of Patients with Advanced Urinary Tract Cancer

scientific article published on 01 April 2019

The National Institute for Health and Care Excellence (NICE) Guidance on Bladder Cancer; a Step in the Right Direction?

scientific article published on 9 February 2017

The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer.

scientific article published on 16 May 2014

The Prognostic Role of the Change in Neutrophil-to-Lymphocyte Ratio During Neoadjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer: A Retrospective, Multi-Institutional Study.

scientific article

The hazards of cross comparing the drug toxicity results from different trials in metastatic renal cancer: in response to a letter from Dr. Catalá-López

scientific article published on 05 November 2012

The latest treatment options for bladder cancer

scientific article published on 01 December 2018

Therapeutic Discovery for Castration Resistant Prostate Cancer: Patient-derived Xenograft Modelling Brings New Options to the Table

scientific article published on 13 July 2018

Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.

scientific article published on 18 August 2009

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

scientific article published on 17 February 2011

Treatment outcome and patterns of relapse following adjuvant carboplatin for stage I testicular seminomatous germ-cell tumour: results from a 17-year UK experience.

scientific article published on 2 June 2015

Tumor cavitation: impact on objective response evaluation in trials of angiogenesis inhibitors in non-small-cell lung cancer.

scientific article published on December 2008

Tumor downstaging as an intermediate endpoint to assess the activity of neoadjuvant systemic therapy in patients with muscle-invasive bladder cancer

scientific article published on 31 May 2019

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

Venous Thromboembolism Risk in Patients With Locoregional Urothelial Tract Tumors.

scientific article published on 24 August 2017

Venous thromboembolism in metastatic urothelial carcinoma or variant histologies: incidence, associative factors, and effect on survival

scientific article published on 20 December 2016

Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

scientific article published on 19 August 2008

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