List of works by Ute Hofmann

6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease

scientific article published in October 2005

A new [2H]-labelledα-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates

scientific article published on 22 October 2014

A pilot 'window of opportunity' neoadjuvant study of metformin in localised prostate cancer.

scientific article published on 27 May 2014

A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes

scientific article published on 9 February 2009

A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells

scientific article

A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation

scientific article

Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells

scientific article

Activation of Epidermal Growth Factor Receptor Sensitizes Glioblastoma Cells to Hypoxia-Induced Cell Death

scientific article published on 03 August 2020

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

scientific article published in May 2005

Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*

scientific article published on 01 June 1996

Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: comparison of sparteine and dextromethorphan.

scientific article published in May 1996

Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways

scientific article published on 6 September 2017

Calcium channel blockers in the management of low-tension and open-angle glaucoma.

scientific article published in December 1993

Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study

Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).

scientific article published on 18 December 2013

Central energy metabolism remains robust in acute steatotic hepatocytes challenged by a high free fatty acid load

scientific article published on 01 July 2012

Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein

scientific article published on March 2005

Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice

scientific article published on 30 July 2004

Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

scientific article published on 01 January 1996

Characterization of the thromboxane synthase pathway product 12-oxoheptadeca-5(Z)-8(E)-10(E)-trienoic acid as a thromboxane A2 receptor antagonist with minimal intrinsic activity.

scientific article

Chemically induced mouse liver tumors are resistant to treatment with atorvastatin

scientific article

Chronopharmacology of intravenous and oral modified release verapamil.

scientific article

Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists

scientific article published on 26 August 2015

Comparative analysis of 3D culture methods on human HepG2 cells

scientific article published on 12 February 2016

Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison

scientific article published on 19 December 2016

Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry

scientific article published in January 2005

Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility

scientific article published on 30 May 2017

Consequences of rifampicin treatment on propafenone disposition in extensive and poor metabolizers of CYP2D6

scientific article published on 01 October 1999

Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis

scientific article

Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency

scientific article

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

scientific article

Designer Thiopurine-analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases.

scientific article published on 25 April 2016

Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy?

scientific article published in April 2010

Determination of fexofenadine in human plasma and urine by liquid chromatography-mass spectrometry

scientific article published in January 2002

Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography-electrospray ionization mass spectrometry

scientific article published on 01 October 2000

Diclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteers

scientific article

Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial.

scientific article

Direct gas chromatographic determination of dechloroethylcyclophosphamide following microsomal incubation of cyclophosphamide

scientific article published on 01 October 1995

Disposition of Propafenone in a Poor Metabolizer of CYP2D6 With Gilbert's Syndrome

scientific article published on 01 June 2000

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

scientific article published on 17 August 2005

Dynamics and control of the central carbon metabolism in hepatoma cells

scientific article

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*

scientific article published on 01 April 1997

Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans

scientific article published on 11 April 2006

Enzymatically Modified Low-Density Lipoprotein Is Present in All Stages of Aortic Valve Sclerosis: Implications for Pathogenesis of the Disease

scientific article published on 16 October 2015

Enzyme induction in the elderly: Effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone

scientific article published on 01 May 2000

Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data

scientific article

Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites

scientific article published on January 2006

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

scientific article published on 01 July 2001

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

scientific article published on May 2005

Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers

scientific article published on 01 July 2000

Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans

scientific article

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

scientific article published on 23 June 2016

Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins

Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2.

scientific article published on 10 August 2016

Heritability of metoprolol and torsemide pharmacokinetics

scientific article published on 7 September 2015

High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs

scientific article published on 29 November 2012

Highly sensitive and specific gas chromatographic-tandem mass spectrometric method for the determination of trace amounts of antipyrine metabolites in biological material

scientific article published on 01 April 1995

Highly sensitive gas chromatographic-tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar range

scientific article

Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I. Experimental observations

scientific article published on June 2008

Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation

scientific article published on June 2008

Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine ⬇️

scientific article published on January 1, 1991

Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans

scientific article published in September 2004

Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

scientific article published on January 1996

Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin

scientific article published on 11 April 2006

In vitro interaction of codeine and diclofenac.

scientific article

Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux

scientific article published on 01 January 2007

Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9.

scientific article

Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib

scientific article

Intestinal absorption, metabolism, and excretion of (-)-epicatechin in healthy humans assessed by using an intestinal perfusion technique

scientific article

LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma

scientific article published on 24 April 2014

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

scientific article published on 8 November 2016

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine

scientific article published on May 2002

Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death

scientific article

Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z, 8E, 10E, 12S)-12-hydroxy-5,8,10-heptadecatrienoic acid as substrate

scientific article

Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner

scientific article published on 13 May 2016

Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS

scientific article published on 01 December 2020

Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes

scientific article published on 20 July 2016

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

scientific article

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

scientific journal article

Ocular pharmacokinetics of verapamil in rabbits

scientific article published on 01 March 1998

Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis

scientific article

P01.31 Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death.

scientific article

Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis

scientific article

Patient education in a 14 month randomized trial fails to improve adherence in ulcerative colitis: Influence of demographic and clinical parameters on non-adherence.

scientific article published on 09 May 2017

Pentafluorophenyldiazoalkanes as novel derivatization reagents for the determination of sensitive carboxylic acids by gas chromatography—negative-ion mass spectrometry

Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine

scientific article published on December 2002

Pharmacokinetics and pharmacodynamics of thiopurines in an in vitro model of human hepatocytes: Insights from an innovative mass spectrometry assay

scientific article published on 12 August 2017

Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing

scientific article

Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis

scientific article published on 01 April 1999

Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

scientific article published on 24 July 2017

Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells

scientific article published on 31 December 2020

Polymorphic sulphoxidation of carbocisteine

scientific article published in The Lancet

Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes

scientific article

Propafenone for the prevention of atrial tachyarrhythmias after cardiac surgery: a randomized, double-blind placebo-controlled trial

scientific article published on 2 January 2008

Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)

scientific article

Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis.

scientific article published on 23 June 2009

Quantitative bile acid profiling by liquid chromatography quadrupole time-of-flight mass spectrometry: monitoring hepatitis B therapy by a novel Na(+)-taurocholate cotransporting polypeptide inhibitor

scientific article

RNAi in murine hepatocytes: the agony of choice--a study of the influence of lipid-based transfection reagents on hepatocyte metabolism

scientific article published on 2 August 2015

Reconstitution of beta-carotene hydroxylase activity of thermostable CYP175A1 monooxygenase

scientific article

Regulation of drug metabolism by the interplay of inflammatory signaling, steatosis, and xeno-sensing receptors in HepaRG cells

scientific article published on 12 January 2018

Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group

scientific article

Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry

scientific article

Sensitive quantification of omeprazole and its metabolites in human plasma by liquid chromatography-mass spectrometry

scientific article

Simple and sensitive method for the determination of celecoxib in human serum by high-performance liquid chromatography with fluorescence detection

scientific article published in March 2002

Simultaneous determination of dihydrocodeine and dihydromorphine in serum by gas chromatography-tandem mass spectrometry

scientific article published on 01 January 1995

Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry

scientific article published on 25 January 2012

Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry

scientific article published on 25 November 2013

Syntheses of Metabolites ofS-Carboxymethyl-L-cysteine andS-Methyl-L-cysteine and of Some Isotopically Labelled (2H,13C) Analogues

scientific article published on 01 December 1990

Synthesis of novel prostaglandin F2α isomers and structure of an enzymatically formed 13-hydroxyprostaglandin endoperoxide

The impact of thyroid disease on the regulation, expression, and function of ABCB1 (MDR1/P glycoprotein) and consequences for the disposition of digoxin

scientific article published on 15 September 2010

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

scientific article published on 28 March 2017

UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo

scientific article published on 30 September 2009

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