List of works - Guido Franzoso

Action of ++clarithromycin against mycoplasma and chlamydia

scientific article published on January 1, 1991

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

scientific article published on 8 December 2014

Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors

scientific article

Cancer: NF-κB regulates energy metabolism.

scientific article published on 10 August 2012

Clinical proof of concept for a safe and effective NF-κB-targeting strategy in multiple myeloma

scientific article published on 26 September 2018

Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues ⬇️

scientific article published on November 1, 2003

Fusion ofMycoplasma fermentansstrain incognitus with T‐lymphocytes ⬇️

scientific article published on June 1, 1992

GADD45β loss ablates innate immunosuppression in cancer ⬇️

scientific article published on 26 December 2017

Gadd45 beta forms a homodimeric complex that binds tightly to MKK7.

scientific article

Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling

scientific article

Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

scientific article published on May 2008

Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries

scientific article published on 14 October 2008

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance

scientific article

In the Crosshairs: NF-κB Targets the JNK Signaling Cascade.

scientific article published on December 2005

Insights into the Interaction Mechanism of DTP3 with MKK7 by Using STD-NMR and Computational Approaches

scientific article published on 30 December 2020

Insights into the Structural Basis of the GADD45β-mediated Inactivation of the JNK Kinase, MKK7/JNKK2

scientific article published in Journal of Biological Chemistry

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages

scientific article published on January 2014

Linking JNK signaling to NF-kappaB: a key to survival

scientific article published in October 2004

Lymphocyte activation and the family of NF-kappa B transcription factor complexes

scientific article published on January 1, 1992

Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways

scientific article published on October 2009

NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes.

scientific article published on February 2006

NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond

scientific article published on 12 June 2019

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

scientific article

NF-κB in the crosshairs: Rethinking an old riddle.

scientific article published on 22 December 2017

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma. ⬇️

scientific article

Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3

scientific article published on 19 April 2019

Probing the interaction interface of the GADD45β/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry.

scientific article published on 20 March 2018

Requirement for NF-κB in osteoclast and B-cell development ⬇️

scientific article published on December 15, 1997

Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice ⬇️

scientific article published on October 1, 2011

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity

scientific article published on 20 April 2015

The NF-kappaB transcription factor pathway as a therapeutic target in cancer: methods for detection of NF-kappaB activity

scientific article published on January 2009

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation ⬇️

scientific article published on September 18, 2012

Turning an old GADDget into a troublemaker.

scientific article published on 6 March 2018

Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.

scientific article published on 22 August 2017

List of works by Guido Franzoso

Action of ++clarithromycin against mycoplasma and chlamydia

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors

Cancer: NF-κB regulates energy metabolism.

Clinical proof of concept for a safe and effective NF-κB-targeting strategy in multiple myeloma

Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues ⬇️

Fusion ofMycoplasma fermentansstrain incognitus with T‐lymphocytes ⬇️

GADD45β loss ablates innate immunosuppression in cancer ⬇️

Gadd45 beta forms a homodimeric complex that binds tightly to MKK7.

Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling

Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance

In the Crosshairs: NF-κB Targets the JNK Signaling Cascade.

Insights into the Interaction Mechanism of DTP3 with MKK7 by Using STD-NMR and Computational Approaches

Insights into the Structural Basis of the GADD45β-mediated Inactivation of the JNK Kinase, MKK7/JNKK2

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages

Linking JNK signaling to NF-kappaB: a key to survival

Lymphocyte activation and the family of NF-kappa B transcription factor complexes

Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways

NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes.

NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

NF-κB in the crosshairs: Rethinking an old riddle.

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma. ⬇️

Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3

Probing the interaction interface of the GADD45β/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry.

Requirement for NF-κB in osteoclast and B-cell development ⬇️

Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice ⬇️

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity

The NF-kappaB transcription factor pathway as a therapeutic target in cancer: methods for detection of NF-kappaB activity

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation ⬇️

Turning an old GADDget into a troublemaker.

Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.