List of works - Lluís Ballell

4-Substituted Thioquinolines and Thiazoloquinolines: Potent, Selective, and Tween-80 in vitro Dependent Families of Antitubercular Agents with Moderate in vivo Activity

scientific article published on 16 September 2011

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.

scientific article

A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis

scientific article published on 2 August 2015

A New Chemical Probe for Proteomics of Carbohydrate-Binding Proteins

scientific article published on 01 February 2005

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors

scientific article published on 5 May 2017

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.

scientific article published on 16 February 2018

A new chemical probe for the detection of the cancer-linked galectin-3

scientific article published on 30 October 2006

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

scientific article

Accelerating early anti-tuberculosis drug discovery by creating mycobacterial indicator strains that predict mode of action.

scientific article published on 16 April 2018

Amino alditols as inhibitors of mycobacterial cell wall biosynthesis

scientific article published in 2002

An Open Toolkit for Tracking Open Science Partnership Implementation and Impact

An open toolkit for tracking open science partnership implementation and impact

scientific article published on 30 April 2019

An open toolkit for tracking open science partnership implementation and impact.

scientific article published on 4 December 2019

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.

scientific article published on 2 March 2018

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

scientific article published on 08 May 2016

Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

scientific article published in Nature Communications

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target

scientific article

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

scientific article published on 18 May 2015

Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes

scientific article published on 4 August 2023

Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent.

scientific article

Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis

scientific article published on 29 December 2014

Discovery of novel InhA reductase inhibitors: application of pharmacophore- and shape-based screening approach

scientific article published on March 2013

Encapsulation of Anti-Tuberculosis Drugs within Mesoporous Silica and Intracellular Antibacterial Activities

scientific article published on 11 September 2014

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

scientific article

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis

scientific article

High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.

scientific article published on 27 October 2014

Hydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif

scientific article

Identification of KasA as the cellular target of an anti-tubercular scaffold

scientific article

Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB

scientific article

Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

scientific article

In vivo Enhancement in Bioavailability of Atazanavir in the Presence of Proton-Pump Inhibitors using Mesoporous Materials

scientific article published on 05 December 2011

In vivo oral toxicological evaluation of mesoporous silica particles

scientific article published on 14 August 2012

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.

scientific article published on 25 August 2017

In vivo potent BM635 analogue with improved drug-like properties

scientific article published on 27 December 2017

Large pore mesoporous silica induced weight loss in obese mice

Microwave-assisted, tin-mediated, regioselective 3-O-alkylation of galactosides

Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation

scientific article

Mycobacterium tuberculosis gyrase inhibitors as a new class of antitubercular drugs

scientific article

N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity

scientific article

New Small-Molecule Synthetic Antimycobacterials

scientific article published in 2007

New Thiopyrazolo[3,4-d]pyrimidine Derivatives as Antimycobacterial Agents

article

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold

scientific article published on 8 February 2016

New small-molecule synthetic antimycobacterials

scientific article

New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents

article

Non-absorbable mesoporous silica for the development of protein sequestration therapies

scientific article published on 05 October 2015

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

scientific article (publication date: 16 December 2016)

Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases

scientific article published on 29 March 2016

Pharmaceutical salt of BM635 with improved bioavailability

scientific article published on 8 December 2016

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

scientific article

Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic

scientific article

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

scientific article

Repurposing clinically approved cephalosporins for tuberculosis therapy

scientific article

Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides.

scientific article

Synthesis and evaluation of mimetics of UDP and UDP-alpha-D-galactose, dTDP and dTDP-alpha-D-glucose with monosaccharides replacing the key pyrophosphate unit.

scientific article

Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3.

scientific article

Synthesis, antimycobacterial activity and influence on mycobacterial InhA and PknB of 12-membered cyclodepsipeptides.

scientific article

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

scientific article

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.

scientific article published on 26 September 2017

Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen

scientific article

Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3

scientific article

The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.

scientific article

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase

scientific article published on 25 August 2015

β-Lactams against Tuberculosis--New Trick for an Old Dog?

scientific article published on 13 July 2016

List of works by Lluís Ballell

4-Substituted Thioquinolines and Thiazoloquinolines: Potent, Selective, and Tween-80 in vitro Dependent Families of Antitubercular Agents with Moderate in vivo Activity

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.

A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis

A New Chemical Probe for Proteomics of Carbohydrate-Binding Proteins

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.

A new chemical probe for the detection of the cancer-linked galectin-3

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

Accelerating early anti-tuberculosis drug discovery by creating mycobacterial indicator strains that predict mode of action.

Amino alditols as inhibitors of mycobacterial cell wall biosynthesis

An Open Toolkit for Tracking Open Science Partnership Implementation and Impact

An open toolkit for tracking open science partnership implementation and impact

An open toolkit for tracking open science partnership implementation and impact.

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes

Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent.

Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis

Discovery of novel InhA reductase inhibitors: application of pharmacophore- and shape-based screening approach

Encapsulation of Anti-Tuberculosis Drugs within Mesoporous Silica and Intracellular Antibacterial Activities

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis

High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.

Hydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif

Identification of KasA as the cellular target of an anti-tubercular scaffold

Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB

Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

In vivo Enhancement in Bioavailability of Atazanavir in the Presence of Proton-Pump Inhibitors using Mesoporous Materials

In vivo oral toxicological evaluation of mesoporous silica particles

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.

In vivo potent BM635 analogue with improved drug-like properties

Large pore mesoporous silica induced weight loss in obese mice

Microwave-assisted, tin-mediated, regioselective 3-O-alkylation of galactosides

Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation

Mycobacterium tuberculosis gyrase inhibitors as a new class of antitubercular drugs

N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity

New Small-Molecule Synthetic Antimycobacterials

New Thiopyrazolo[3,4-d]pyrimidine Derivatives as Antimycobacterial Agents

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold

New small-molecule synthetic antimycobacterials

New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents

Non-absorbable mesoporous silica for the development of protein sequestration therapies

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases

Pharmaceutical salt of BM635 with improved bioavailability

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

Repurposing clinically approved cephalosporins for tuberculosis therapy

Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides.

Synthesis and evaluation of mimetics of UDP and UDP-alpha-D-galactose, dTDP and dTDP-alpha-D-glucose with monosaccharides replacing the key pyrophosphate unit.

Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3.

Synthesis, antimycobacterial activity and influence on mycobacterial InhA and PknB of 12-membered cyclodepsipeptides.

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.

Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen

Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3

The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase

β-Lactams against Tuberculosis--New Trick for an Old Dog?