List of works - Michael I Page

"Orbital steering", entropy, and rate accelerations

scientific article published in April 1974

A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

article published in 1998

A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives

A highly diastereoselective synthesis of tricyclic lactams and their application as novel N-acyl iminium ion precursors in the synthesis of isoindolinone derivatives

A new approach to the synthesis of non-racemic isoindolin-1-one derivatives

A tetrahedral intermediate in the aminolysis of benzylpenicillin

Acyl vs sulfonyl transfer in N-acyl beta-sultams and 3-oxo-beta-sultams.

scientific article published in January 2004

Acylating agents as enzyme inhibitors and understanding their reactivity for drug design

scientific article

Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultams

scientific article published in June 2005

An Activated Sulfonylating Agent That Undergoes General Base-Catalyzed Hydrolysis by Amines in Preference to Aminolysis

scientific article published on 15 May 2008

An esterase with β-lactamase activity

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors

scientific article

Beta-sultams-mechanism of reactions and use as inhibitors of serine proteases

scientific article published on May 2004

Binding energy and enzymic catalysis

scientific article published on 01 September 1976

Chapter 1 The energetics and specificity of enzyme—substrate interactions

Chapter 7 The mechanisms of chemical catalysis used by enzymes

Competitive endo- and exo-cyclic C N fission in the hydrolysis of N-aroyl β-lactams

Copper catalysed azide–alkyne cycloaddition (CuAAC) in liquid ammonia

scientific article published on 01 October 2012

Copper(I)-Catalyzed Amination of Aryl Halides in Liquid Ammonia

scientific article published on 13 August 2012

Corrigendum to “Highly diastereoselective synthesis and template manipulation of the thiazolo[2,3-a]isoindolin-1-one ring system”

scholarly article published in Tetrahedron Letters

Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase.

scientific article published in February 2001

Different transition-state structures for the reactions of beta-lactams and analogous beta-sultams with serine beta-lactamases

scientific article

Dynamic Kinetic Resolution for the Synthesis of Esters, Amides and Acids Using Lipases

Ease of C–N bond cleavage in four-membered rings

article published in 1987

Enantioselective biotransformations using rhodococci

scientific article published on 01 July 1998

Energy differences and their relevance to enzyme and intramolecular catalysis

Entropic rate accelerations and orbital steering

scientific article published on 01 November 1972

Enzyme Deactivation Due to Metal-Ion Dissociation during Turnover of the Cobalt-β-Lactamase Catalyzed Hydrolysis of β-Lactams†

scientific article published on 01 September 2006

Highly diastereoselective synthesis and template manipulation of the thiazolo[2,3-a]isoindolin-1-one ring system

Inactivation of bacterial DD-peptidase by beta-sultams

scientific article published in May 2005

Inhibitors of metallo-beta-lactamase generated from beta-lactam antibiotics.

scientific article

Intra-and inter-molecular general base catalysis in the aminolysis of benzylpenicillin

Intramolecular general acid catalysis in the aminolysis of benzylpenicillin. A preferred direction of nucleophilic attack

Intramolecular general acid catalysis in the aminolysis of beta-lactam antibiotics

scientific article published on 9 February 2004

Intramolecular nucleophilic and general acid catalysis in the hydrolysis of an amide

Ionization of carbon acids in liquid ammonia

scientific article

Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporins

scientific article

Kinetics of the conversion of methyl benzoate to benzamide by the alumina catalysed reaction with liquid ammonia at 120 °C

Large rate enhancement for the hydrolysis of a four-membered ring phosphonamidate

Liquid ammonia as a dipolar aprotic solvent for aliphatic nucleophilic substitution reactions

scientific article

Loss of enzyme activity during turnover of the Bacillus cereus beta-lactamase catalysed hydrolysis of beta-lactams due to loss of zinc ion.

scientific article published in May 2008

Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride).

scientific article published on 18 December 2006

Micelle Formation in Liquid Ammonia

scientific article

Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase

scientific article

Novel mechanism of inhibiting beta-lactamases by sulfonylation using beta-sultams

scientific article published in December 2003

Organic reactivity in liquid ammonia

article

Peptidase activity of beta-lactamases.

scientific article published in July 1999

Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide (PADS)

scientific article published on 17 August 2016

Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the sulfurisation of phosphites by phenylacetyl disulfide (PADS)

scientific article published on 01 November 2016

Preface

Reactive intermediates in the H-phosphonate synthesis of oligonucleotides.

scientific article

Reactivity and selectivity in the inhibition of elastase by 3-oxo-β-sultams and in their hydrolysis

scientific article published on 30 October 2007

Sphingosine and dihydrosphingosine as biomarkers for multiple sclerosis identified by metabolomic profiling using coupled UPLC-MS

Stereochemical studies. Part 112. Geometrical dependence of intramolecular catalysis in the hydrolysis and aminolysis of aryl esters

Stereochemistry and ring opening of a carbocyclic analogue of a 1-oxapenam

Structure-reactivity relationships in the inactivation of elastase by beta-sultams

scientific article published in January 2003

Synthesis and antimicrobial activity of some isoindolin-1-ones derivatives.

scientific article published in August 2000

Synthesis, conformation and antiproliferative activity of isothiazoloisoxazole 1,1-dioxides

scientific article published on 14 January 2016

The Kinetics and Mechanisms of Aromatic Nucleophilic Substitution Reactions in Liquid Ammonia

scientific article published on 31 March 2011

The Mechanisms of Reactions of β-Lactam Antibiotics

The Variation of Catalytic Efficiency ofBacilluscereusMetallo-β-lactamase with Different Active Site Metal Ions†

scientific article published on 01 September 2006

The activity of the dinuclear cobalt-beta-lactamase from Bacillus cereus in catalysing the hydrolysis of beta-lactams

scientific article published on January 2007

The aminolysis of N-aroyl β-lactams occurs by a concerted mechanism

scientific article published on 21 December 2006

The energetics of neighbouring group participation

The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives

scientific article published in April 2004

The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution

scientific article

The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzene (Oo′-benzylidenecatechol) and benzaldehyde diphenyl acetal

The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzoic acid (OO′-benzylidene-2,3-dihydroxybenzoic acid)

The kinetics and mechanism of the organo-iridium catalysed racemisation of amines ⬇️

scientific article published on 5 July 2016

The kinetics and mechanism of the organo-iridium-catalysed enantioselective reduction of imines

scientific article published on 17 March 2016

The mechanism of hydrolysis of 2,3-OO-benzylidene-norbornane-exo-2,-exo-3-diols

The mechanism of reactions catalysed by the serine β-lactamases

scholarly article by Andrew P Laws et al published November 1993 in Bioorganic & Medicinal Chemistry Letters

The mechanism of the phosphoramidite synthesis of polynucleotides

scientific article

The mechanisms of catalysis by metallo beta-lactamases

scientific article published on January 2008

The principles of enzymatic catalysis

scientific article published on January 1979

List of works by Michael I Page

"Orbital steering", entropy, and rate accelerations

A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives

A highly diastereoselective synthesis of tricyclic lactams and their application as novel N-acyl iminium ion precursors in the synthesis of isoindolinone derivatives

A new approach to the synthesis of non-racemic isoindolin-1-one derivatives

A tetrahedral intermediate in the aminolysis of benzylpenicillin

Acyl vs sulfonyl transfer in N-acyl beta-sultams and 3-oxo-beta-sultams.

Acylating agents as enzyme inhibitors and understanding their reactivity for drug design

Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultams

An Activated Sulfonylating Agent That Undergoes General Base-Catalyzed Hydrolysis by Amines in Preference to Aminolysis

An esterase with β-lactamase activity

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors

Beta-sultams-mechanism of reactions and use as inhibitors of serine proteases

Binding energy and enzymic catalysis

Chapter 1 The energetics and specificity of enzyme—substrate interactions

Chapter 7 The mechanisms of chemical catalysis used by enzymes

Competitive endo- and exo-cyclic C N fission in the hydrolysis of N-aroyl β-lactams

Copper catalysed azide–alkyne cycloaddition (CuAAC) in liquid ammonia

Copper(I)-Catalyzed Amination of Aryl Halides in Liquid Ammonia

Corrigendum to “Highly diastereoselective synthesis and template manipulation of the thiazolo[2,3-a]isoindolin-1-one ring system”

Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase.

Different transition-state structures for the reactions of beta-lactams and analogous beta-sultams with serine beta-lactamases

Dynamic Kinetic Resolution for the Synthesis of Esters, Amides and Acids Using Lipases

Ease of C–N bond cleavage in four-membered rings

Enantioselective biotransformations using rhodococci

Energy differences and their relevance to enzyme and intramolecular catalysis

Entropic rate accelerations and orbital steering

Enzyme Deactivation Due to Metal-Ion Dissociation during Turnover of the Cobalt-β-Lactamase Catalyzed Hydrolysis of β-Lactams†

Highly diastereoselective synthesis and template manipulation of the thiazolo[2,3-a]isoindolin-1-one ring system

Inactivation of bacterial DD-peptidase by beta-sultams

Inhibitors of metallo-beta-lactamase generated from beta-lactam antibiotics.

Intra-and inter-molecular general base catalysis in the aminolysis of benzylpenicillin

Intramolecular general acid catalysis in the aminolysis of benzylpenicillin. A preferred direction of nucleophilic attack

Intramolecular general acid catalysis in the aminolysis of beta-lactam antibiotics

Intramolecular nucleophilic and general acid catalysis in the hydrolysis of an amide

Ionization of carbon acids in liquid ammonia

Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporins

Kinetics of the conversion of methyl benzoate to benzamide by the alumina catalysed reaction with liquid ammonia at 120 °C

Large rate enhancement for the hydrolysis of a four-membered ring phosphonamidate

Liquid ammonia as a dipolar aprotic solvent for aliphatic nucleophilic substitution reactions

Loss of enzyme activity during turnover of the Bacillus cereus beta-lactamase catalysed hydrolysis of beta-lactams due to loss of zinc ion.

Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride).

Micelle Formation in Liquid Ammonia

Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase

Novel mechanism of inhibiting beta-lactamases by sulfonylation using beta-sultams

Organic reactivity in liquid ammonia

Peptidase activity of beta-lactamases.

Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide (PADS)

Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the sulfurisation of phosphites by phenylacetyl disulfide (PADS)

Preface

Reactive intermediates in the H-phosphonate synthesis of oligonucleotides.

Reactivity and selectivity in the inhibition of elastase by 3-oxo-β-sultams and in their hydrolysis

Sphingosine and dihydrosphingosine as biomarkers for multiple sclerosis identified by metabolomic profiling using coupled UPLC-MS

Stereochemical studies. Part 112. Geometrical dependence of intramolecular catalysis in the hydrolysis and aminolysis of aryl esters

Stereochemistry and ring opening of a carbocyclic analogue of a 1-oxapenam

Structure-reactivity relationships in the inactivation of elastase by beta-sultams

Synthesis and antimicrobial activity of some isoindolin-1-ones derivatives.

Synthesis, conformation and antiproliferative activity of isothiazoloisoxazole 1,1-dioxides

The Kinetics and Mechanisms of Aromatic Nucleophilic Substitution Reactions in Liquid Ammonia

The Mechanisms of Reactions of β-Lactam Antibiotics

The Variation of Catalytic Efficiency ofBacilluscereusMetallo-β-lactamase with Different Active Site Metal Ions†

The activity of the dinuclear cobalt-beta-lactamase from Bacillus cereus in catalysing the hydrolysis of beta-lactams

The aminolysis of N-aroyl β-lactams occurs by a concerted mechanism

The energetics of neighbouring group participation

The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives

The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution

The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzene (Oo′-benzylidenecatechol) and benzaldehyde diphenyl acetal

The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzoic acid (OO′-benzylidene-2,3-dihydroxybenzoic acid)

The kinetics and mechanism of the organo-iridium catalysed racemisation of amines ⬇️

The kinetics and mechanism of the organo-iridium-catalysed enantioselective reduction of imines

The mechanism of hydrolysis of 2,3-OO-benzylidene-norbornane-exo-2,-exo-3-diols

The mechanism of reactions catalysed by the serine β-lactamases

The mechanism of the phosphoramidite synthesis of polynucleotides

The mechanisms of catalysis by metallo beta-lactamases

The principles of enzymatic catalysis

The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate

Thiazolidine ring opening in penicillin derivatives. Part 1. Imine formation

Thiazolidine ring opening in penicillin derivatives. Part 2. Enamine formation

Transition states, standard states and enzymic catalysis