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List of works by Pietro Sormanni

A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate

scientific article published on 20 July 2015

A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

scientific article published on 12 May 2018

A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data.

scientific article published on 23 May 2019

A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

scientific article published on 06 March 2019

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

scientific article

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.

scientific article published on 10 August 2016

An aggregation inhibitor specific to oligomeric intermediates of Aβ42 derived from phage display libraries of stable, small proteins

scientific article published on 17 May 2022

Attentive Cross-Modal Paratope Prediction

scientific article published on 01 December 2018

Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity

scientific article published on 28 August 2019

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

scientific article

Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain

scientific article published on 07 March 2018

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles

scientific article published on 8 November 2017

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

Fibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperone

scientific article

Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming

scientific article published on 18 April 2019

In vitro and in silico assessment of the developability of a designed monoclonal antibody library

scientific article published on 18 January 2019

Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains

scientific article published on 24 December 2019

Iterative derivation of effective potentials to sample the conformational space of proteins at atomistic scale ⬇️

scientific article published in May 2014

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery

scientific article published on 13 February 2018

MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins.

scientific article published on 10 November 2017

Modulating the cardiotoxic behaviour of immunoglobulin light chain dimers through point mutations

scientific article published on 01 January 2019

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

scientific article published on 10 December 2021

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

scientific article published on 2 October 2017

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

Parapred: antibody paratope prediction using convolutional and recurrent neural networks

scientific article published on 01 September 2018

Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis

scientific article published on 02 December 2019

Proteome-wide observation of the phenomenon of life on the edge of solubility

scientific article published on 31 December 2019

Rapid and accurate in silico solubility screening of a monoclonal antibody library.

scientific article

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

scientific article published on 03 June 2020

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

scientific article

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

scientific article published on 6 May 2016

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

scientific article

Simultaneous quantification of protein order and disorder

scientific article published in March 2017

Subdomain architecture and stability of a giant repeat protein.

scientific article published on 20 September 2013

Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease

scientific article published on 19 November 2019

Targeting disordered proteins with small molecules using entropy

scientific article published on 11 August 2015

The CamSol method of rational design of protein mutants with enhanced solubility

scientific article published on 14 October 2014

The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins

scientific article

Third generation antibody discovery methods: in silico rational design

scientific article published on 01 December 2018

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

scientific article

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