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List of works by Kirk E Hevener

A simplified protocol for high-yield expression and purification of bacterial topoisomerase I.

scientific article

A statistical framework to evaluate virtual screening

scientific article published on 20 July 2009

Comparison of radii sets, entropy, QM methods, and sampling on MM-PBSA, MM-GBSA, and QM/MM-GBSA ligand binding energies of F. tularensis enoyl-ACP reductase (FabI).

scientific article

Computational Toxicology Methods in Chemical Library Design and High-Throughput Screening Hit Validation

scientific article published on 01 January 2018

Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matching

scientific article

Expression, purification and characterization of enoyl-ACP reductase II, FabK, from Porphyromonas gingivalis.

scientific article

High-level expression, purification, and characterization of Staphylococcus aureus dihydroorotase (PyrC) as a cleavable His-SUMO fusion.

scientific article published on 13 December 2012

High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes

scientific article (publication date: 2013)

Hit identification and optimization in virtual screening: practical recommendations based on a critical literature analysis

scientific article

Hit-to-Lead: Hit Validation and Assessment

scientific article published on 25 October 2018

Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives

scientific article published on 26 December 2018

Quantitative structure-activity relationship studies on nitrofuranyl anti-tubercular agents

scientific article published on 29 July 2008

Recent Advances in the Rational Design and Optimization of Antibacterial Agents

scientific article published on 7 July 2016

Recent developments in topoisomerase-targeted cancer chemotherapy.

scientific article

Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden.

scientific article published on 05 July 2016

Small-Molecule Inhibition of the C. difficile FAS-II Enzyme, FabK, Results in Selective Activity

scientific article published on 26 June 2019

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

scientific article

Structural and Enzymatic Analyses Reveal the Binding Mode of a Novel Series of Francisella tularensis Enoyl Reductase (FabI) Inhibitors ⬇️

scientific article published on June 8, 2012

Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI)

scientific article

Structural characterization of Porphyromonas gingivalis enoyl-ACP reductase II (FabK).

scientific article published on 26 January 2018

Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors

scientific article

Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents

scientific article

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection

scientific article published on 13 December 2018

The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites

scientific article

Validation of molecular docking programs for virtual screening against dihydropteroate synthase

scientific article published on February 2009

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