List of works - Philippe Pierre

1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes.

scientific article published on 9 August 2013

Antigen capture, processing, and presentation by dendritic cells: recent cell biological studies.

scientific article

Assessment of foraging devices as a model for decision-making in nonhuman primate environmental enrichment.

scientific article

At the crossway of ER-stress and proinflammatory responses.

scientific article published on 23 January 2018

Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation

scientific article published in March 2012

BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells.

scientific article published on 13 October 2017

BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons

scientific journal article

BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells

scientific article

Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors

scientific journal article

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

scientific article

Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1.

scientific article

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

scientific article published on 08 July 2013

Cannabinoid receptor 1 and acute resistance exercise--In vivo and in vitro studies in human skeletal muscle

scientific article

Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff

scientific article

Cystatin F is secreted, but artificial modification of its C-terminus can induce its endocytic targeting

scientific article

DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells

scientific article published on 19 November 2010

Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins

scientific article

Dendritic cells, DRiPs, and DALIS in the control of antigen processing.

scientific article

Detection of a Subset of Posttranscriptional Transfer RNA Modifications in Vivo with a Restriction Fragment Length Polymorphism-Based Method.

scientific article published on 13 July 2017

Developmental regulation of MHC class II transport in mouse dendritic cells.

scientific article published on August 1997

Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.

scientific article published in June 1998

Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies.

scientific article

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

scientific article published on 18 January 2021

Exaggerated translation causes synaptic and behavioural aberrations associated with autism ⬇️

scientific article published on December 23, 2012

Exploring the mechanisms of antigen processing by cell fractionation

scientific article published on 01 April 1998

Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway ⬇️

scientific article published on May 21, 2013

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

scientific article published on 14 June 2016

Genetic modification of murine dendritic cells by RNA transfection.

scientific article published in January 2009

Guanabenz Prevents d-Galactosamine/Lipopolysaccharide-Induced Liver Damage and Mortality

scientific article

Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments.

scientific article published on March 1996

Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs

scientific article

Imaging of protein synthesis with puromycin.

scientific article published on 23 March 2012

In vivo imaging of the spatiotemporal activity of the eIF2 -ATF4 signaling pathway: Insights into stress and related disorders

scientific article published on 28 April 2015

Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.

scientific article

Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expression ⬇️

scientific article published on July 26, 2013

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation ⬇️

scientific article published on February 2, 2011

Integrating stress responses and immunity

scientific article published on 01 July 2019

Integration of ER stress and viral nucleotide sensing in DCs: Mounting a response commensurate to the threat?

article

Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response.

scientific article published on 12 May 2015

Intercellular adhesion molecule-1 expression by skeletal muscle cells augments myogenesis.

scientific article

LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain

scientific article

Large G3BP-induced granules trigger eIF2α phosphorylation ⬇️

scientific article published on July 25, 2012

Localization and Intracellular Transport of MHC Class II Molecules in Bone Marrow-Derived Dendritic Cells ⬇️

scientific article published on 01 January 1997

Lonely MHC molecules seeking immunogenic peptides for meaningful relationships.

scientific article published on August 1995

Loss of translation: a stealth weapon against pathogens?

scientific article published in December 2013

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

scientific article published on 31 May 2017

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

scientific article

MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity

scientific article published on 03 August 2016

Mapping the crossroads of immune activation and cellular stress response pathways

scientific article published on 12 April 2013

Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A.

scientific article published on 19 July 2013

Molecular dissection of plasmacytoid dendritic cell activation during a viral infection

scientific article published on 21 August 2018

Most human proteins made in both nucleus and cytoplasm turn over within minutes

scientific article

Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation

scientific article published on 10 October 2012

Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins

scientific article published on 31 October 2012

Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique

scientific article

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

scientific article published on 24 January 2008

Nuclear translation visualized by ribosome-bound nascent chain puromycylation.

scientific article

PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins

scientific article

Polymerase III transcription is necessary for T cell priming by dendritic cells

scientific article published on 21 October 2019

Polyploids require Bik1 for kinetochore–microtubule attachment ⬇️

scientific article published on December 24, 2001

Progressively impaired proteasomal capacity during terminal plasma cell differentiation

scientific article

Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells

scientific article published on 6 February 2012

Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.

scientific article published on 18 January 2017

Protein synthesis regulation, a pillar of strength for innate immunity?

scientific article published on 29 December 2014

Protéases, inhibiteurs naturels de protéase et activation de la machinerie de présentation antigénique dans les cellules dendritiques

scientific article published on 01 July 2001

Purification and Analysis of Authentic CLIP-170 and Recombinant Fragments

scientific article published in Journal of Biological Chemistry

RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes.

scientific article

RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages

scientific article published on 14 July 2021

RUFY4: Immunity piggybacking on autophagy?

scientific article published on 13 January 2016

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

scientific article

Regulation of protein synthesis and autophagy in activated dendritic cells: implications for antigen processing and presentation.

scientific article published on July 2016

Regulation of translation is required for dendritic cell function and survival during activation

scientific article published on December 2007

Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS.

scientific article

Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response

scientific article

Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis.

scientific article

Species-specific impact of the autophagy machinery on Chikungunya virus infection

scientific article

SunRiSE: measuring translation elongation at single cell resolution by flow cytometry.

scientific article published on 26 April 2018

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits ⬇️

scientific article published on August 11, 2013

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease

scientific article

Systems biology of infectious diseases: a focus on fungal infections

scientific article published on 16 August 2011

Transient aggregation of ubiquitinated proteins during dendritic cell maturation

scientific article

Understanding the cell biology of antigen presentation: the dendritic cell contribution.

scientific article

Unfolded protein response gene GADD34 is overexpressed in rheumatoid arthritis and related to the presence of circulating anti-citrullinated protein antibodies.

scientific article published on February 2016

Voronto: mapper for expression data to ontologies.

scientific article

List of works by Philippe Pierre

1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes.

Antigen capture, processing, and presentation by dendritic cells: recent cell biological studies.

Assessment of foraging devices as a model for decision-making in nonhuman primate environmental enrichment.

At the crossway of ER-stress and proinflammatory responses.

Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation

BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells.

BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons

BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells

Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1.

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

Cannabinoid receptor 1 and acute resistance exercise--In vivo and in vitro studies in human skeletal muscle

Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff

Cystatin F is secreted, but artificial modification of its C-terminus can induce its endocytic targeting

DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells

Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins

Dendritic cells, DRiPs, and DALIS in the control of antigen processing.

Detection of a Subset of Posttranscriptional Transfer RNA Modifications in Vivo with a Restriction Fragment Length Polymorphism-Based Method.

Developmental regulation of MHC class II transport in mouse dendritic cells.

Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.

Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies.

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Exaggerated translation causes synaptic and behavioural aberrations associated with autism ⬇️

Exploring the mechanisms of antigen processing by cell fractionation

Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway ⬇️

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

Genetic modification of murine dendritic cells by RNA transfection.

Guanabenz Prevents d-Galactosamine/Lipopolysaccharide-Induced Liver Damage and Mortality

Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments.

Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs

Imaging of protein synthesis with puromycin.

In vivo imaging of the spatiotemporal activity of the eIF2 -ATF4 signaling pathway: Insights into stress and related disorders

Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.

Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expression ⬇️

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation ⬇️

Integrating stress responses and immunity

Integration of ER stress and viral nucleotide sensing in DCs: Mounting a response commensurate to the threat?

Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response.

Intercellular adhesion molecule-1 expression by skeletal muscle cells augments myogenesis.

LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain

Large G3BP-induced granules trigger eIF2α phosphorylation ⬇️

Localization and Intracellular Transport of MHC Class II Molecules in Bone Marrow-Derived Dendritic Cells ⬇️

Lonely MHC molecules seeking immunogenic peptides for meaningful relationships.

Loss of translation: a stealth weapon against pathogens?

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity

Mapping the crossroads of immune activation and cellular stress response pathways

Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A.

Molecular dissection of plasmacytoid dendritic cell activation during a viral infection

Most human proteins made in both nucleus and cytoplasm turn over within minutes

Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation

Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins

Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

Nuclear translation visualized by ribosome-bound nascent chain puromycylation.

PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins

Polymerase III transcription is necessary for T cell priming by dendritic cells

Polyploids require Bik1 for kinetochore–microtubule attachment ⬇️

Progressively impaired proteasomal capacity during terminal plasma cell differentiation

Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells

Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.

Protein synthesis regulation, a pillar of strength for innate immunity?

Protéases, inhibiteurs naturels de protéase et activation de la machinerie de présentation antigénique dans les cellules dendritiques

Purification and Analysis of Authentic CLIP-170 and Recombinant Fragments

RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes.

RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages

RUFY4: Immunity piggybacking on autophagy?

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

Regulation of protein synthesis and autophagy in activated dendritic cells: implications for antigen processing and presentation.

Regulation of translation is required for dendritic cell function and survival during activation

Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS.

Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response

Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis.

Species-specific impact of the autophagy machinery on Chikungunya virus infection