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List of works by Richard G Gorlick

A Decade in Banking Ewing Sarcoma: A Report from the Children's Oncology Group

scientific article published on 20 March 2013

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

scientific article

A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells

scientific article

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

scientific article published on 11 May 2015

A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma

scientific article

A phase II study of eribulin in recurrent or refractory osteosarcoma: A report from the Children's Oncology Group

scientific article published on 30 October 2018

A review of targeted therapies evaluated by the pediatric preclinical testing program for osteosarcoma.

scientific article published on 31 May 2013

A summary of the osteosarcoma banking efforts: a report from the Children's Oncology Group and the QuadW Foundation

scientific article

ABBV-085, antibody-drug conjugate targeting LRRC15, is effective in osteosarcoma: A report by the Pediatric Preclinical Testing Consortium

scientific article published on 09 December 2020

Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma

scientific article published on April 2003

Abstract 4593: Genome-wide association study identifies novel loci associated with osteosarcoma

Abstract 5574: High prevalence of germline TP53 mutations in young osteosarcoma cases

Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.

scientific article

Acute stroke-like encephalopathy associated with high-dose methotrexate impurities

scientific article published in July 2000

Addition of pamidronate to chemotherapy for the treatment of osteosarcoma

scientific article

Aggressively recurrent infantile myofibroma of the axilla and shoulder girdle.

scientific article published on 27 October 2010

Ambulatory high-dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost-effective

scientific article

An 19F magnetic resonance-based in vivo assay of solid tumor methotrexate resistance: proof of principle.

scientific article published on February 2005

An expression signature classifies chemotherapy-resistant pediatric osteosarcoma

scientific article published on 01 March 2005

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

journal article published in 2015

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children's oncology group study

scientific article published on 31 October 2013

Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Group Bone Tumor Committee.

scientific article published on 29 April 2016

Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions: A report from the Children's Oncology Group.

scientific article

Assessment of patient experiences following total sacrectomy for primary malignant sacral tumors: A qualitative study

scientific article published on 08 November 2019

Biology and therapeutic advances for pediatric osteosarcoma

scientific article published in January 2004

Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary.

scientific article published on November 2003

Biomarker significance of plasma and tumor miR-21, miR-221, and miR-106a in osteosarcoma.

scientific article published on 27 May 2017

Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells

scientific article published on July 2007

Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models

scientific article published on 18 December 2018

CD49b inhibits osteogenic differentiation and plays an important role in osteosarcoma progression.

scientific article published on 23 September 2017

Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma

scientific article

Cell proliferation of cultured human cancer cells are affected by the elevated tumor pressures that exist in vivo

scientific article

Cell surface receptor expression patterns in osteosarcoma

scientific article published on 12 July 2011

Challenges of Clinical Management of Adolescent and Young Adults With Bone and Soft Tissue Sarcoma

scientific article published on 01 November 2018

Characterization and drug sensitivity of four newly established colon adenocarcinoma cell lines to antifolate inhibitors of thymidylate synthase

scientific article

Characterization of bony anatomic regions in pediatric and adult healthy volunteers using diffuse optical spectroscopic imaging

scientific article published on 01 August 2020

Chemotherapy resistance in osteosarcoma: current challenges and future directions.

scientific article published on July 2006

Children's Oncology Group's 2013 blueprint for research: bone tumors

scientific article

Clinical trial enrollment of adolescents and young adults with sarcoma.

scientific article published on 11 May 2017

Collaborations between SSO and the Connective Tissue Oncology Society (CTOS) series

scientific article published on 07 July 2015

Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program.

scientific article

Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program.

scientific article published on 29 April 2011

Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. ⬇️

scientific article

Comparison of Surface Area across the Allograft-Host Junction Site Using Conventional and Navigated Osteotomy Technique

scientific article published on 18 December 2012

Contributors

Correction: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group

scientific article published on 01 April 2019

Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma

scientific article

Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis

scientific article published on January 2007

Current and future therapeutic approaches for osteosarcoma.

scientific article published on 6 December 2017

Current concepts on the molecular biology of osteosarcoma.

scientific article published on January 2009

Current practice managements regarding thromboembolic prophylaxis within the pediatric sarcoma patient population

scientific article published on 01 January 2013

Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop.

scientific article

DNA Methylation-Based Classifier for Accurate Molecular Diagnosis of Bone Sarcomas

scientific article published on 06 October 2017

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.

scientific article published on 21 April 2009

Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression.

scientific article published in February 1997

Detectable clonal mosaicism and its relationship to aging and cancer

journal article published in 2012

Detection and targeting insulin growth factor receptor type 2 (IGF2R) in osteosarcoma PDX in mouse models and in canine osteosarcoma tumors

scientific article published on 07 August 2019

Detection of circulating tumor DNA in patients with osteosarcoma.

scientific article published on 18 January 2018

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group

scientific article published on 21 August 2018

Development of IGF-IR Inhibitors in Pediatric Sarcomas.

scientific article published on July 2009

Development of a Model System to Evaluate Local Recurrence in Osteosarcoma and Assessment of the Effects of Bone Morphogenetic Protein-2.

scientific article

Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway

scientific article

Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells ⬇️

scientific article published on 01 August 1997

Divergent patterns of telomere maintenance mechanisms among human sarcomas: sharply contrasting prevalence of the alternative lengthening of telomeres mechanism in Ewing's sarcomas and osteosarcomas

scientific article published on October 2004

Dose Intensification Improves the Outcome of Ewing Sarcoma

scientific article published on 12 September 2018

Dose-response effect of eribulin in preclinical models of osteosarcoma by the pediatric preclinical testing consortium

scientific article published on 24 July 2020

Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma

scientific article published in Scientific Reports

EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment

scientific article

Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line

scientific article published on September 1996

Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children's Oncology Group

scientific article published on 28 October 2019

Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer.

scientific article published on 30 March 2011

Elevated physiologic tumor pressure promotes proliferation and chemosensitivity in human osteosarcoma

scientific article

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) New Agents for Ewing Sarcoma Task Force

scientific article published on 15 April 2019

Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis

scientific article published on 5 August 2016

Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray

scientific article

Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse

scientific article published in January 2005

Ewing's sarcoma in a patient with congenital optic atrophy

scientific article published on 01 November 1998

Expression of HER2/erbB-2 correlates with survival in osteosarcoma

scientific article published on 01 September 1999

Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma

scientific article published on March 2004

Expression of bone morphogenetic proteins and receptors in sarcomas

scientific article

FCGR2APolymorphism Is Correlated With Clinical Outcome After Immunotherapy of Neuroblastoma With Anti-GD2 Antibody and Granulocyte Macrophage Colony-Stimulating Factor

article by Nai-Kong V. Cheung et al published 20 June 2006 in Journal of Clinical Oncology

Factors influencing survival after recurrence in osteosarcoma: A report from the Children's Oncology Group

scientific article published on 25 September 2018

Feasibility and dose discovery analysis of zoledronic acid with concurrent chemotherapy in the treatment of newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group

scientific article published on 07 May 2013

Fluoropyrimidine resistance in colon cancer.

scientific article published in August 2002

Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma

scientific article published on 19 March 2020

Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma

scientific article published on January 2004

Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas.

scientific article

Future directions in the treatment of osteosarcoma.

scientific article published on 30 November 2015

Ganglioside GD2 as a therapeutic target for antibody-mediated therapy in patients with osteosarcoma.

scientific article published on 25 October 2013

Ganglioside GD2 expression is maintained upon recurrence in patients with osteosarcoma

scientific article

Genetically transforming human mesenchymal stem cells to sarcomas: changes in cellular phenotype and multilineage differentiation potential

scientific article published on October 2009

Genetically transforming human osteoblasts to sarcoma: development of an osteosarcoma model

scientific article

Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma

scientific article

Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

scientific article published on 6 December 2017

Genome-wide association study identifies two susceptibility loci for osteosarcoma

scientific article (publication date: July 2013)

Genomic Analysis Does Not Support Malignant Transformation of Osteoblastoma to Osteosarcoma

scientific article published on 09 September 2019

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

scientific article published on 01 November 2019

Germline TP53 variants and susceptibility to osteosarcoma.

scientific article

HER-2 expression is not prognostic in osteosarcoma; a Children's Oncology Group prospective biology study.

scientific article

HER-2 involvement in osteosarcoma

scientific article

HER-2 targeted treatment of osteosarcoma: the challenges of developing targeted therapy and prognostic factors for rare malignancies

scientific article published on January 2010

HER2-Targeted Therapy in Osteosarcoma

scientific article published on 01 January 2020

HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival

scientific article published on 17 August 2016

High P-glycoprotein-mediated export observed in patients with a history of idiopathic thrombocytopenic purpura

scientific article

High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008

scientific article published on 25 September 2019

High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis.

scientific article published in June 2001

High-dose methotrexate in osteosarcoma: let the questions surcease--time for final acceptance.

scientific article

Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma

scientific article published on 01 April 1998

Human epidermal growth factor receptor 2 as a prognostic indicator in osteogenic sarcoma

scientific article published on 01 January 2001

Hypoxia markers in human osteosarcoma: an exploratory study.

scientific article published on 5 June 2008

IGF-1R targeted treatment of sarcoma.

scientific article published on 23 December 2009

Identification of Patients With Localized Ewing Sarcoma at Higher Risk for Local Failure: A Report From the Children's Oncology Group.

scientific article published on 24 August 2017

Identification of prognostic markers in bone sarcomas using proton-decoupled phosphorus magnetic resonance spectroscopy.

scientific article published in December 2003

Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Bone Tumor Committee

scientific article published on August 2008

Immune approaches to treating osteosarcoma.

scientific article published on 31 May 2009

Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma

scientific article published on 26 July 2016

Immuno-genomic landscape of osteosarcoma

scientific article published on 21 February 2020

Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group

scientific article published on 09 February 2016

Impairment of methotrexate transport is common in osteosarcoma tumor samples

scientific article published on 22 December 2010

Impairments in antifolate transport are common in retinoblastoma tumor samples

scientific article published in 2008

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

journal article published in 2014

In vivo, noninvasive functional measurements of bone sarcoma using diffuse optical spectroscopic imaging

scientific article published in December 2017

Increased methotrexate polyglutamylation in acute megakaryocytic leukemia (M7) compared to other subtypes of acute myelocytic leukemia

scientific article published on 01 June 1997

Induction of NKG2D ligand expression on tumor cells by CD8+ T-cell engagement-mediated activation of nuclear factor-kappa B and p300/CBP-associated factor

scientific article published on 19 August 2019

Inhaled lipid cisplatin (ILC) in the treatment of patients with relapsed/progressive osteosarcoma metastatic to the lung.

scientific article published on 19 December 2012

Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo

scientific article

Initial Testing (Stage 1) of MK-8242-A Novel MDM2 Inhibitor-by the Pediatric Preclinical Testing Program.

scientific article published on 30 May 2016

Initial Testing of NSC 750854, a Novel Purine Analog, Against Pediatric Tumor Models by the Pediatric Preclinical Testing Program

scientific article

Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

scientific article published on 24 March 2020

Initial in vivo testing of TPO-receptor agonist eltrombopag in osteosarcoma patient-derived xenograft models by the pediatric preclinical testing consortium

scientific article published on 17 August 2020

Initial solid tumor testing (stage 1) of AZD1480, an inhibitor of Janus kinases 1 and 2 by the pediatric preclinical testing program

scientific article

Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the pediatric preclinical testing program.

scientific article

Initial testing (Stage 1) of TAK-701, a humanized hepatocyte growth factor binding antibody, by the Pediatric Preclinical Testing Program.

scientific article published on 09 September 2013

Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program

scientific article

Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling

scientific article published on 16 August 2011

Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program.

scientific article

Initial testing (stage 1) of BAL101553, a novel tubulin binding agent, by the pediatric preclinical testing program

scientific article published on 18 November 2014

Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program

scientific article published on 16 June 2011

Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program.

scientific article published on 2 November 2011

Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

scientific article published on June 2008

Initial testing (stage 1) of eribulin, a novel tubulin binding agent, by the pediatric preclinical testing program

scientific article

Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the Pediatric Preclinical Testing Program

scientific article

Initial testing (stage 1) of glembatumumab vedotin (CDX-011) by the pediatric preclinical testing program.

scientific article

Initial testing (stage 1) of lapatinib by the pediatric preclinical testing program

scientific article published on October 2009

Initial testing (stage 1) of mapatumumab (HGS-ETR1) by the pediatric preclinical testing program

scientific article published on February 2010

Initial testing (stage 1) of temozolomide by the pediatric preclinical testing program

scientific article

Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program.

scientific article

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

scientific article published on June 2008

Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program.

scientific article

Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673.

scientific article published on 27 September 2014

Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program.

scientific article

Initial testing (stage 1) of the anti-microtubule agents cabazitaxel and docetaxel, by the pediatric preclinical testing program.

scientific article published on 7 July 2015

Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program.

scientific article published on 21 September 2016

Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program.

scientific article

Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program

scientific article

Initial testing (stage 1) of the investigational mTOR kinase inhibitor MLN0128 by the pediatric preclinical testing program

scientific article

Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program.

scientific article published on December 2009

Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program.

scientific article

Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program

scientific article

Initial testing (stage 1) of the multi-targeted kinase inhibitor sorafenib by the pediatric preclinical testing program

scientific article published on December 2010

Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program

scientific article

Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program.

scientific article

Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program.

scientific article

Initial testing (stage 1) of the tubulin binding agent nanoparticle albumin-bound (nab) paclitaxel (Abraxane(®)) by the Pediatric Preclinical Testing Program (PPTP).

scientific article

Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program.

scientific article published on September 2009

Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program.

scientific article published on 15 September 2011

Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program.

scientific article published on 27 October 2016

Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program.

scientific article

Initial testing of aplidin by the pediatric pre-clinical testing program.

scientific article published on September 2009

Initial testing of cisplatin by the pediatric preclinical testing program

scientific article published on May 2008

Initial testing of dasatinib by the pediatric preclinical testing program

scientific article

Initial testing of lenalidomide by the pediatric preclinical testing program

scientific article published on 25 February 2011

Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program

scientific article

Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program

scientific article

Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program

scientific article published on March 2008

Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).

scientific article

Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program.

scientific article

Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program.

scientific article published on 19 October 2011

Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing program

scientific article

Initial testing of topotecan by the pediatric preclinical testing program.

scientific article

Insulin-like growth factor 1 receptor and response to anti-IGF1R antibody therapy in osteosarcoma

scientific article

Integrating mechanisms of response and resistance against the tubulin binding agent Eribulin in preclinical models of osteosarcoma.

scientific article

Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol

scientific article published on 01 July 1998

Intrinsic and acquired resistance to methotrexate in acute leukemia.

scientific article

Irinotecan for pediatric solid tumors: the Memorial Sloan-Kettering experience

scientific article

Lack of correlation of functional scintigraphy with (99m)technetium-methoxyisobutylisonitrile with histological necrosis following induction chemotherapy or measures of P-glycoprotein expression in high-grade osteosarcoma.

scientific article

Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase

scientific article

Leydig cell tumor after treatment for Ewing's sarcoma

scientific article published on 01 December 2007

LigaSure Use Decreases Intraoperative Blood Loss Volume and Blood Transfusion Volume in Sarcoma Surgery

scientific article published on 01 November 2019

Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group.

scientific article published on 23 May 2016

Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults.

scientific article published in September 2003

Loss of antibody titers and effectiveness of revaccination in post-chemotherapy pediatric sarcoma patients

scientific article published on 01 October 2007

Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site

scientific article published on 01 March 2003

Malignant ectomesenchymoma in the wrist of a child: case report and review of the literature.

scientific article

Mechanical analysis of the vascularized fibular graft prosthetic composite (VFGPC) for internal hemipelvectomy reconstruction.

scientific article published on 22 May 2017

Mechanisms of methotrexate resistance in osteosarcoma

scientific article published on 01 March 1999

Mesenchymal chondrosarcoma: clinicopathologic study of 20 cases

scientific article published on 01 January 2012

Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma

scientific article

Metachronous skeletal osteosarcoma in patients treated with adjuvant and neoadjuvant chemotherapy for nonmetastatic osteosarcoma

scientific article published on 01 January 2003

Methotrexate levels and outcome in osteosarcoma

scientific article published in June 2005

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good R

scientific article

Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma

scientific article published in March 2002

Molecular characterization of the pediatric preclinical testing panel

scientific article

Monitoring methotrexate levels in osteosarcoma

scientific article published on 01 June 1998

Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma: a case report and review of the literature

scientific article published on 01 September 1998

Multiple drug resistance in osteogenic sarcoma: INT0133 from the Children's Oncology Group

scientific article published on 01 May 2007

New targets and approaches in osteosarcoma.

scientific article published on 14 September 2012

Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase

scientific article (publication date: 18 July 2002)

Novel therapeutic agents for osteosarcoma

scientific article published on April 2009

Numb chin syndrome in Ewing sarcoma

scientific article published on 01 November 2000

Osteogenic and Ewing sarcomas: estimation of necrotic fraction during induction chemotherapy with dynamic contrast-enhanced MR imaging

scientific article published in July 2003

Osteosarcoma

scientific article published on 01 August 1997

Osteosarcoma Necrosis Following Chemotherapy: Innate Biology Versus Treatment-Specific ⬇️

scientific article published on 01 November 2003

Osteosarcoma associated with absent thumbs: a report of two cases

scientific article

Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation

scientific article published on 21 July 2017

Osteosarcoma.

scientific article

Osteosarcoma: Current Treatment and a Collaborative Pathway to Success

scientific article (publication date: 20 September 2015)

Osteosarcoma: a review of diagnosis, management, and treatment strategies

scientific article published on October 1, 2010

Outcome for adolescent and young adult patients with osteosarcoma: a report from the Children's Oncology Group

scientific article

Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move Forward

scientific article

Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma.

scientific article published on September 2007

Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification

PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors

scientific article

Pediatric Oncology Provider Views on Performing a Biopsy of Solid Tumors in Children with Relapsed or Refractory Disease for the Purpose of Genomic Profiling.

scientific article published on 26 July 2016

Pediatric oncologist willingness to offer germline TP53 testing in osteosarcoma.

scientific article published on 3 January 2018

Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program.

scientific article

Phase 1 and pharmacokinetic study of concurrent carboplatin and irinotecan in subjects aged 1 to 21 years with refractory solid tumors.

scientific article

Phase 2 trial of pemetrexed in children and adolescents with refractory solid tumors: a Children's Oncology Group study

scientific article

Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma

scientific article

Phase II trial of the glycoprotein non-metastatic B-targeted antibody-drug conjugate, glembatumumab vedotin (CDX-011), in recurrent osteosarcoma AOST1521: A report from the Children's Oncology Group

scientific article published on 03 October 2019

Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group

scientific article

Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group

scientific article published on 18 November 2015

Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma

scientific article published on May 2008

Polymorphisms and methylation of the reduced folate carrier in osteosarcoma.

scientific article published on 5 June 2008

Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma.

scientific article

Preclinical evaluation of the combination of AZD1775 and irinotecan against selected pediatric solid tumors: A Pediatric Preclinical Testing Consortium report

scientific article published on 23 January 2020

Predictive properties of DNA methylation patterns in primary tumor samples for osteosarcoma relapse status

scientific article

Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity ⬇️

scientific article published on February 1, 1998

Provider views on the management of Ewing sarcoma of the spine and pelvis

scientific article published on 16 October 2017

Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group

scientific article published on 29 July 2019

Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma

scientific article published on 14 August 2013

Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier

scientific article

R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts

scientific article

Rapid Protocol Enrollment in Osteosarcoma: A Report From the Children's Oncology Group

scientific article published on 16 September 2015

Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis

scientific article published on 31 July 2020

Reconstruction of the pediatric midface following oncologic resection

scientific article published on 24 March 2015

Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study

scientific article published in September 2003

Resistance Mechanisms to Methotrexate in Tumors

scientific article published on 01 January 1996

Resistance mechanisms to methotrexate in tumors.

scientific article published on January 1996

Second malignant neoplasms in long-term survivors of osteosarcoma: Memorial Sloan-Kettering Cancer Center Experience

scientific article published in October 2002

Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples.

scientific article

Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma

scientific article published on 02 July 2020

Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program

scientific article

Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells.

scientific article published on January 2004

Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort

scientific article published on 25 January 2019

Synergistic activity of PARP inhibition by talazoparib (BMN 673) with temozolomide in pediatric cancer models in the pediatric preclinical testing program.

scientific article

Targeted therapy of osteosarcoma with radiolabeled monoclonal antibody to an insulin-like growth factor-2 receptor (IGF2R).

scientific article published on 30 July 2016

Targeting Glycoprotein NMB With Antibody-Drug Conjugate, Glembatumumab Vedotin, for the Treatment of Osteosarcoma.

scientific article published on 25 August 2015

Testing of new agents in childhood cancer preclinical models: meeting summary

scientific article published on 01 December 2002

Testing of the Akt/PKB inhibitor MK-2206 by the Pediatric Preclinical Testing Program.

scientific article published on 18 November 2011

Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program.

scientific article

The Memorial Sloan Kettering Cancer Center experience with outpatient administration of high dose methotrexate with leucovorin rescue.

scientific article published on June 2008

The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC.

scientific article

The case for informative phase 2 trials in osteosarcoma

scientific article published on 01 August 2016

The effect of bone morphogenetic protein-2 on osteosarcoma metastasis.

scientific article

The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate

scientific article published on May 2007

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

scientific article published on 4 January 2004

The patterns of relapse in osteosarcoma: the Memorial Sloan-Kettering experience

scientific article published in January 2004

The pediatric preclinical testing program: description of models and early testing results.

scientific article published in December 2007

The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability ⬇️

scientific article

Therapy for osteosarcoma: where do we go from here?

scientific article published on January 2008

To B(MP-2) or Not To B(MP-2): Cytokines and Tumor Surgery—Letter

scientific article

Toward a drug development path that targets metastatic progression in osteosarcoma.

scientific article

Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-b as Involved in the Pathogenesis of Osteosarcoma

scientific article

Treatment algorithm for locally recurrent osteosarcoma based on local disease-free interval and the presence of lung metastasis.

scientific article published in October 2006

Treatment of osteosarcoma at first recurrence after contemporary therapy: the Memorial Sloan-Kettering Cancer Center experience.

scientific article

Tumor interstitial fluid pressure may regulate angiogenic factors in osteosarcoma.

scientific article

Tumor thrombus in the large veins draining primary pelvic osteosarcoma on cross sectional imaging

scientific article published on 21 May 2018

Tumor-targeted IL-12 combined with tumor resection yields a survival-favorable immune profile.

scientific article

Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group

scientific article

Tumour interstitial fluid pressure may regulate angiogenic factors in osteosarcoma

scientific article published on December 2009

VEGF expression in osteosarcoma correlates with vascular permeability by dynamic MRI

scientific article published in September 2004

Variability in the reported management of pulmonary metastases in osteosarcoma

scientific article

Vulvar fibromatosis: a clinical enigma.

scientific article

gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias

scientific article published on 01 January 1997

mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.

scientific article

p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma

β-Catenin Does Not Confer Tumorigenicity When Introduced into Partially Transformed Human Mesenchymal Stem Cells.

scientific article published on 18 October 2012

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