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List of works by Mark R. Denison

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease ⬇️

scientific article

A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant

scientific article

A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing

scientific article published on 2 April 2008

ANDES: Statistical tools for the ANalyses of DEep Sequencing

scientific article

An mRNA Vaccine against SARS-CoV-2 - Preliminary Report

scientific article published on 14 July 2020

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

scientific article (preprint)

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

scientific article published on 06 April 2020

Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing

scientific article published on 11 April 2007

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

scientific article published in September 2019

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential.

scientific article published on 4 October 2017

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

scientific article

Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase.

scientific article published in October 2003

Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity

scientific article published on 11 September 2013

Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication

scientific article

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

scientific article published on 10 January 2020

Coronavirus Picornain-like Cysteine Proteinase

Coronavirus Protein Processing and RNA Synthesis Is Inhibited by the Cysteine Proteinase Inhibitor E64d

article

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

scientific article

Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation.

scientific article

Coronavirus replication complex formation utilizes components of cellular autophagy

scientific article published on 29 December 2003

Coronavirus replication does not require the autophagy gene ATG5

scientific article published on 24 July 2007

Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity

scientific article

Coronaviruses induce entry-independent, continuous macropinocytosis

scientific article

Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics

scientific article (publication date: August 2013)

Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity

scientific article

Determinants of mouse hepatitis virus 3C-like proteinase activity.

scientific article published in April 1997

Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus

scientific article

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

scientific article published on 03 December 2020

Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture

scientific article published in January 2006

Evaluation of candidate vaccine approaches for MERS-CoV.

scientific article published on 28 July 2015

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses

scientific article

Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing.

scientific article

FATAL FAT EMBOLISM SYNDROME IN A CHILD WITH UNDIAGNOSED HEMOGLOBIN S/Beta+ THALASSEMIA: A Complication of Acute Parvovirus B19 Infection

article by Kathryn A. Kolquist et al published 1 February 1996 in Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association

Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus

scientific article published on 15 October 2019

Fitness barriers limit reversion of a proofreading-deficient coronavirus

scientific article published on 27 April 2019

Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly.

scientific article

Genetic analysis of Murine hepatitis virus nsp4 in virus replication

scientific article

H1N1 infection mimicking the clinical presentation of gastrointestinal GVHD in a patient following allo-SCT

scientific article published on 12 April 2010

High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.

scientific article

Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens

scientific article published on 08 June 2016

Identification and Characterization of a 65-kDa Protein Processed from the Gene 1 Polyprotein of the Murine Coronavirus MHV-A59

article

Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins

scientific article published on September 2004

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

scientific article published on 14 August 2017

Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses.

scientific article published on August 2012

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

scientific article published on 7 March 2018

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins.

scientific article published on 31 January 2017

Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing

scientific article

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses

scientific article published on 17 August 2016

Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication.

scientific article

Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events

scientific article published on 01 July 1992

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.

scientific article published on 8 June 2015

MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication

scientific article published on 01 January 2006

Middle East Respiratory Syndrome.

scientific article

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012

scientific article

Molecular targets for the rational design of drugs to inhibit SARS coronavirus

scientific article published on 03 October 2004

Mouse hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity

scientific article published on 30 August 2017

Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection.

scientific article published in June 2001

Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes

scientific article

Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2

scientific article published on 22 April 2020

Murine Hepatitis Virus Nonstructural Protein 4 Regulates Virus-Induced Membrane Modifications and Replication Complex Function

scientific article

Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization

scientific article published on 24 September 2008

Murine hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity

scientific article published on 18 October 2017

Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive ⬇️

scientific article published on October 23, 2012

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis

scientific article published on 28 March 2007

Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.

scientific article published on June 2016

Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication

scientific article

Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications

scientific article

Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity

scientific article published on 8 April 2015

Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

scientific article published on 28 April 2022

Neonatal renal abscess caused by Staphylococcus aureus ⬇️

scientific article published on June 1, 1991

Novel poxvirus infection in 2 patients from the United States

scientific article published on 9 October 2014

Nucleoside analogues for the treatment of coronavirus infections

scientific article published in April 2019

Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication

scientific article published on 18 July 2007

Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations.

scientific article published on 7 November 2017

Proofreading-deficient coronaviruses adapt over long-term passage for increased fidelity and fitness without reversion of exoribonuclease-inactivating mutations

scientific article published on 12 August 2017

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

scientific article published on 07 July 2020

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

scientific article published on 28 April 2020

Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3.

scientific article

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

scientific article published on 20 October 2003

SARS coronavirus accessory ORFs encode luxury functions

scientific article published on January 2006

SARS coronavirus replicase proteins in pathogenesis

scientific article published on 29 March 2007

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

scientific article published on 11 June 2020

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

scientific article published on 05 August 2020

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

scientific article published on 29 September 2020

Seeking Membranes: Positive-Strand RNA Virus Replication Complexes

scientific article (publication date: 28 October 2008)

Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.

scientific article published in May 2018

Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry.

scientific article published on 24 June 2015

Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice

scientific article

Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update.

scientific article

Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice

scientific article published on March 2005

Small-Molecule Antiviral β-d--Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

scientific article published on 01 September 2019

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

scholarly article

Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59.

scientific article

Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity

scientific article

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication

scientific article published on January 2006

The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication

scientific article

Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses

scientific article published on 2 June 2014

Unilateral facial paralysis occurring in an infant with enteroviral otitis media and aseptic meningitis

scientific article published on 01 April 2002

Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus.

scientific article

Viral pharyngitis

scientific article published on 01 April 1995

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