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List of works by Enzo Medico

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits

scientific article published on 04 October 2019

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

scientific article published on 07 March 2019

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.

scientific article published on 3 October 2017

A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart.

scientific article

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

scientific article published on 12 December 2019

A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells

scientific article

A gene trap vector system for identifying transcriptionally responsive genes.

scientific article published in June 2001

A genome-wide trap screening procedure for transcriptionally responsive genes

article

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

scientific article

A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells

scientific article published on 14 August 2007

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models

scientific article

BRAF V600E is a determinant of sensitivity to proteasome inhibitors

scientific article

Biochemical and immunological properties of the human carcinoma antigen CAR-5 defined by the monoclonal antibody BD-5.

scientific article

Cancer and blood coagulation.

scientific article

Cardiac concentric hypertrophy promoted by activated Met receptor is mitigated in vivo by inhibition of Erk1,2 signalling with Pimasertib.

scientific article published on 25 February 2016

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

scientific article

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

scientific article published on 01 August 2020

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

scientific article published on 07 January 2021

Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.

scientific article published on July 2015

Detection of gene communities in multi-networks reveals cancer drivers

scientific article

Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A

scientific article

Dysregulation of MS risk genes and pathways at distinct stages of disease

scientific article published on 16 March 2017

Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer

scientific article

Electrical conditioning of adipose-derived stem cells in a multi-chamber culture platform

scientific article published on 17 February 2014

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

scientific article

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

scientific article published on 28 June 2019

Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes

scientific article

FLAME, a novel fuzzy clustering method for the analysis of DNA microarray data

scientific article

Formalin fixation at low temperature better preserves nucleic acid integrity.

scientific article

Gender-based blood transcriptomes and interactomes in multiple sclerosis: involvement of SP1 dependent gene transcription

scientific article published on 25 November 2011

Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms

scientific article

Gene trapping: a multi-purpose tool for functional genomics.

scientific article published on January 2003

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

article

High-throughput molecular analysis from leftover of fine needle aspiration cytology of mammographically detected breast cancer.

scientific article

IGF-II binding to insulin receptor isoform A induces a partially different gene expression profile from insulin binding.

scientific article

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

scientific article published on January 2015

IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas.

scientific article published on 18 January 2018

Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells.

scientific article published on 28 June 2013

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

scientific article published on 30 August 2018

Individual cell-based models of cell scatter of ARO and MLP-29 cells in response to hepatocyte growth factor.

scientific article

Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer

scientific article published on 4 April 2011

Inhibition of Src impairs the growth of met-addicted gastric tumors.

scientific article published on 13 July 2010

Integration of transcriptomic data and metabolic networks in cancer samples reveals highly significant prognostic power

scientific article published on 20 September 2018

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

Isolation and characterization of a spontaneously immortalized multipotent mesenchymal cell line derived from mouse subcutaneous adipose tissue

scientific article published on 09 August 2013

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

scientific article published on 18 January 2017

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.

scientific article published in June 2013

Met-driven invasive growth involves transcriptional regulation of Arhgap12.

scientific article

MicroRNA-mRNA interactions underlying colorectal cancer molecular subtypes.

scientific article

Mulcom: a multiple comparison statistical test for microarray data in Bioconductor

scientific article

Multipotent mesenchymal stem cells from amniotic fluid originate neural precursors with functional voltage-gated sodium channels

scientific article published in January 2009

Only a subset of Met-activated pathways are required to sustain oncogene addiction

scientific article

PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas

scientific article

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

scientific article published in November 2017

Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study

scientific article

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

scientific article published on 02 August 2019

Predicting locally advanced rectal cancer response to neoadjuvant therapy with 18F-FDG PET and MRI radiomics features

scientific article published on 13 January 2019

Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature.

scientific article published on June 2013

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies ⬇️

scientific article published on 7 February 2018

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

scientific article

Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells

scientific article published on 20 August 2019

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.

scientific article published on 22 March 2018

Search for neuro-endocrine markers (chromogranin A, synaptophysin and VGF) in breast cancers. An integrated approach using immunohistochemistry and gene expression profiling

scientific article

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

scientific article published on 31 May 2017

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research

scientific article published in January 2019

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

scientific article published on 5 March 2012

Stromal contribution to the colorectal cancer transcriptome.

scientific article

The Dilemma of HER2 Double-equivocal Breast Carcinomas: Genomic Profiling and Implications for Treatment

scientific article published on 01 September 2018

The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer

scientific article

The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.

scientific article published on March 1996

The MET oncogene drives a genetic programme linking cancer to haemostasis

scientific article published in Nature

The MET oncogene is a functional marker of a glioblastoma stem cell subtype.

scientific article

The RNA-binding protein ESRP1 promotes human colorectal cancer progression

scientific article published on 28 December 2016

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

scientific article

The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.

scientific article

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

scientific article published on 30 April 2015

The tyrosine kinase receptor met and its ligand HGF are co-expressed and functionally active in HHV-8 positive primary effusion lymphoma.

scientific article published on February 2000

Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair.

scientific article published on 14 February 2012

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.

scientific article published on 14 December 2016

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