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List of works by Alain Puisieux

<i>In Vivo</i> Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters

scientific article published on 09 December 2020

A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes.

scientific article published on September 2017

A p21/WAF1 mutation favors the appearance of drug resistance to paclitaxel in human noncancerous epithelial mammary cells

scientific article published in July 2006

A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability.

scientific article

A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma.

scientific article

ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells.

scientific article

Absence of p53-dependent induction of the metastatic suppressor KAI1 gene after DNA damage

scientific article published on 01 May 2000

Absence of rearrangements in the BRCA2 gene in human cancers.

scientific article published on January 2001

Alteration of p53 damage response by tamoxifen treatment

scientific article published on 01 September 1996

Alterations of anaphase-promoting complex genes in human colon cancer cells

scientific article

Antigenic determinants on human choriogonadotropin alpha-subunit. II. Immunochemical mapping by a monoclonal antipeptide antibody

scientific article published on 01 July 1988

Assessing Cell Activities rather than Identities to Interpret Intra-Tumor Phenotypic Diversity and Its Dynamics

scientific article published on 13 April 2020

BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling.

scientific article published on 29 July 2008

BTG gene expression in the p53-dependent and -independent cellular response to DNA damage

scientific article published on 01 February 2000

BTG2(TIS21/PC3) induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells

scientific article (publication date: 3 October 2002)

BTG2, its family and its tutor.

scientific article published in July 2004

Bromohydrin pyrophosphate-stimulated Vgamma9delta2 T cells expanded ex vivo from patients with poor-prognosis neuroblastoma lyse autologous primary tumor cells

scientific article published on July 2010

C. elegans homologue of the Caf1 gene, which encodes a subunit of the CCR4-NOT complex, is essential for embryonic and larval development and for meiotic progression.

scientific article published in September 2005

CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues

scientific article published on 21 September 2011

CDYL2 Epigenetically Regulates MIR124 to Control NF-κB/STAT3-Dependent Breast Cancer Cell Plasticity

scientific article published on 06 May 2020

Cancer patients who experienced diagnostic genetic testing for cancer susceptibility: reactions and behavior after the disclosure of a positive test result.

scientific article published on January 2002

Cancer stem cells: the emerging challenge of drug targeting.

scientific article published on January 2009

Cell cycle gene regulation in reversibly differentiated new human hepatoma cell lines.

scientific article published on February 1998

Cellular Pliancy and the Multistep Process of Tumorigenesis.

scientific article published in February 2018

Characterization of a cleavage product in the human choriogonadotropin beta-subunit.

scientific article published in July 1988

Chfr inactivation is not associated to chromosomal instability in colon cancers

scientific article (publication date: 4 December 2003)

Circulating MYCN DNA as a tumor-specific marker in neuroblastoma patients

scientific article published on 01 July 2002

Circulating MYCN DNA predicts MYCN-amplification in neuroblastoma

scientific article published on 01 December 2005

Combined nanomedicines targeting colorectal cancer stem cells and cancer cells

scientific article published on 20 July 2020

Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution

scientific article published on 09 July 2020

Copper isotope effect in serum of cancer patients. A pilot study.

scientific article published on February 2015

Correction: Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas

scientific article published on 6 August 2009

Correction: Sulfur isotope analysis by MC-ICP-MS and application to small medical samples

Deciphering the molecular mechanisms underlying the binding of the TWIST1/E12 complex to regulatory E-box sequences

scientific article published on 05 May 2016

Deregulation of TWIST-1 in the CD34+ compartment represents a novel prognostic factor in chronic myeloid leukemia

scientific article published on December 2010

Destabilization of the TWIST1/E12 complex dimerization following the R154P point-mutation of TWIST1: an in silico approach.

scientific article

Detection of exon deletions and duplications of the mismatch repair genes in hereditary nonpolyposis colorectal cancer families using multiplex polymerase chain reaction of short fluorescent fragments

scientific article published on 01 June 2000

Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA

scientific article published on 11 January 2011

Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics.

scientific article

Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells

scientific article published on 24 May 2015

EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.

scientific article

EMT transcription factor ZEB1 represses the mutagenic POLθ-mediated end-joining pathway in breast cancers

scientific article published on 25 November 2020

Early origin of cancer metastases: dissemination and evolution of premalignant cells.

scientific article published on 19 December 2008

Effect of bortezomib on human neuroblastoma: analysis of molecular mechanisms involved in cytotoxicity

scientific article published on 5 June 2008

Epithelial-mesenchymal transition transcription factors and miRNAs: "Plastic surgeons" of breast cancer

scientific article published on August 2014

Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.

scientific article published on February 2002

Failsafe program escape and EMT: a deleterious partnership.

scientific article published on 05 October 2011

Fifteen important questions for oncology to be addressed from 2015

scientific article published on 01 June 2015

Gadd45a activation protects melanoma cells from ultraviolet B-induced apoptosis.

scientific article published on 16 August 2007

Genome-wide analysis of gene expression in neuroblastomas detected by mass screening

scientific article

Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma.

scientific article published on 20 July 2016

Germline hMSH2 and hMLH1 gene mutations in incomplete HNPCC families

scientific article published on 01 December 1997

Gestational trophoblastic neoplasms (GTNs) do not display epithelial-to-mesenchymal transition (EMT) features

scientific article published on 08 March 2019

Guidelines and definitions for research on epithelial-mesenchymal transition

scientific article published on 16 April 2020

Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity

scientific article

Immunochemical mapping of antigenic regions on the human thyrotropin beta-subunit by antipeptide antibodies

scientific article published on 01 October 1991

Immunological and classical subtypes of oral premalignant lesions

scientific article published on 21 September 2018

Impaired IFN- Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

article

Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas

scientific article published on 24 July 2009

Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity

scientific article

Increased expression of the thyroid hormone nuclear receptor TRα1 characterizes intestinal tumors with high Wnt activity.

scientific article published on 24 July 2018

Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

scientific article

Influence of Nucleoshuttling of the ATM Protein in the Healthy Tissues Response to Radiation Therapy: Toward a Molecular Classification of Human Radiosensitivity

scientific article published on 14 November 2015

Influence of neuroblastoma stage on serum-based detection of MYCN amplification

scientific article

Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine.

scientific article published on January 2003

Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer.

scientific article

Intensity-dependent constitutional MLH1 promoter methylation leads to early onset of colorectal cancer by affecting both alleles

scientific article published on 09 December 2010

Interhelical loops within the bHLH domain are determinant in maintaining TWIST1-DNA complexes.

scientific article published on 25 March 2013

Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus.

scientific article

Les Entretiens Jacques Cartier Symposium 4--targeted cancer therapies: stakes and prospects for patients

scientific article published on 01 March 2015

Lobular and ductal carcinomas of the breast have distinct genomic and expression profiles

scientific article

Low frequency of TSG101/CC2 gene alterations in invasive human breast cancers.

scientific article published in February 1998

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

scientific article

MSH2 in contrast to MLH1 and MSH6 is frequently inactivated by exonic and promoter rearrangements in hereditary nonpolyposis colorectal cancer

scientific article published on 01 February 2002

Metabolomics and cytotoxicity of monomethylhydrazine (MMH) and (E)-1,1,4,4-tetramethyl-2-tetrazene (TMTZ), two liquid propellants

scientific article published on 07 June 2018

Metastasis: a question of life or death

scientific article (publication date: June 2006)

Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells.

scientific article published on April 2011

Modulation of oxidative stress by twist oncoproteins

scientific article

Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells.

scientific article published on 6 August 2010

Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes

scientific article published on 22 April 2011

Mutational targets in colorectal cancer cells with microsatellite instability.

scientific article

Netrin-1 acts as a survival factor for aggressive neuroblastoma

scientific article

Neurofibromatosis and early onset of cancers in hMLH1-deficient children

scientific article published on 01 January 1999

Neurofibromatosis type 1 gene as a mutational target in a mismatch repair-deficient cell type.

scientific article

Novel biallelic mutations in MSH6 and PMS2 genes: gene conversion as a likely cause of PMS2 gene inactivation.

scientific article

Occurrence of fragmentation of free and combined forms of the beta-subunit of human chorionic gonadotropin

scientific article published on 01 February 1990

Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells.

scientific article

Oncogenic roles of EMT-inducing transcription factors

scientific article published on June 2014

PLA2R1 kills cancer cells by inducing mitochondrial stress.

scientific article published on 29 August 2013

PLA2R1 mediates tumor suppression by activating JAK2.

scientific article published on 5 September 2013

Paclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype.

scientific article

Pleiotropic Roles for ZEB1 in Cancer.

scientific article published on 18 December 2017

Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphisms

scientific article

Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer

scientific article (publication date: 1999)

Prognostic significance of urokinase plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in lymph node- and hormone receptor-positive breast cancer.

scientific article

Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype.

scientific article published on August 2009

Prognostic value of P53 gene mutations in a large series of node-negative breast cancer patients

scientific article published on 01 April 1998

Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73.

scientific article published on 28 November 2007

Protein chip array profiling analysis of sera from neuroblastoma patients

scientific article

Quantifying local malignant adaptation in tissue‐specific evolutionary trajectories by harnessing cancer’s repeatability at the genetic level

scientific article published on 18 March 2019

Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions ⬇️

scientific article

Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome.

scientific article published on 24 February 2009

Repeated radiation dose effect and DNA repair: Importance of the individual factor and the time interval between the doses

scientific article

Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.

scientific article published on November 1993

Revisiting the canonical tumour progression model

scientific article published on 15 March 2010

Ribosomal RNA 2'O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer

scientific article published on 22 December 2020

Role of epithelial-mesenchymal transition factors in the histogenesis of uterine carcinomas

scientific article published on 09 February 2019

Role of epithelial-mesenchymal transition in tumor progression ⬇️

scientific article published on 01 December 2009

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens

scientific article published on 01 November 1991

Should we consider cancers as embryonic diseases or as consequences of stem-cell deregulation?

scientific article

Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells.

scientific article

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

scientific article published on October 2008

Splicing factor ratio as an index of epithelial-mesenchymal transition and tumor aggressiveness in breast cancer

scientific article

Stiffness measurement is a biomarker of skin aging in vivo

scientific article published on 23 September 2020

Structural probing of human lutropin using antibodies raised against synthetic peptides constructed by classical and multiple antigen peptide system approaches

scientific article published on 01 April 1990

Structure-activity relationship study: Mechanism of cyto-genotoxicity of Nitropyrazole-derived high energy density materials family

Sulfur isotope analysis by MC-ICP-MS and application to small medical samples

Systematic mRNA analysis for the effect of MLH1 and MSH2 missense and silent mutations on aberrant splicing.

scientific article

TIF1γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability.

scientific article published on 17 August 2015

TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma

scientific article

TWIST1 expression in breast cancer cells facilitates bone metastasis formation.

scientific article published on August 2014

TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma

scientific article

The CD10 enzyme is a key player to identify and regulate human mammary stem cells.

scientific article published in June 2010

The Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial Cells

scientific article published on May 2016

The SNAIL family member SCRATCH1 is not expressed in human tumors.

scientific article

The cell-of-origin dictates the genomic landscape of breast cancers.

scientific article published on 16 June 2017

The emerging role of Twist proteins in hematopoietic cells and hematological malignancies

scientific article

The emerging role of Twist proteins in hematopoietic cells and hematological malignancies

scientific article published on 24 October 2014

The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene

scientific article (publication date: 9 January 2002)

The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade.

scientific article published on 28 April 2017

The neurogene BTG2TIS21/PC3 is transactivated by DeltaNp73alpha via p53 specifically in neuroblastoma cells.

scientific article published on March 2005

Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition

scientific article published on 15 November 2012

Tight junction protein claudin-2 promotes self-renewal of human colorectal cancer stem-like cells.

scientific article published on 6 March 2018

Toxicokinetics and tolerance of a high energy material 3,4,5-trinitropyrazole (TNP) in mice

scientific article published on 26 June 2018

Tspan8-β-catenin positive feedback loop promotes melanoma invasion

scientific article published on 24 January 2019

UVB-induced G2 arrest of human melanocytes involves Cdc2 sequestration by Gadd45a in nuclear speckles

scientific article published on 15 August 2006

Upstream ORF affects MYCN translation depending on exon 1b alternative splicing

scientific article

Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer

scientific article published on 3 September 2011

Weekly administration of paclitaxel induces long-term aneugenicity in nude mice.

scientific article published on 13 March 2007

ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors

scientific article published on 05 September 2016

Zeb1 expression by tumor or stromal cells is associated with spatial distribution patterns of CD8+ tumor-infiltrating lymphocytes: a hypothesis-generating study on 113 triple negative breast cancers

scientific article published on 01 October 2020

[An alternate model of tumoral progression].

scientific article published on 19 April 2011

[Cancer cell plasticity and metastatic dissemination].

scientific article published on 12 September 2016

[Cancer cells escape from failsafe programs in a simple Twist].

scientific article

[Cancer cells. Genetic anomalies (oncogenes and anti-oncogenes), growth factors, apoptosis and dissemination, prognostic impact]

scientific article published on 01 May 2000

[Cell cycle and breast cancer]

scientific article published on 01 January 2000

[Contribution and challenges of Big Data in oncology].

scientific article

[Epithelial-mesenchymal transition and liver fibrosis : guilty or not guilty?]

scientific article published on 01 January 2012

[Epithelial-to-mesenchymal transition and cancer-initiating cells]

scientific article published on 20 November 2017

[Genotypic analysis and immunohistochemistry in human cancers: conflicting or complementary information?]

scientific article published on 01 April 2002

[Immunotherapy of poor-prognosis neuroblastoma in children: from bench to bedside]

scientific article published on 01 February 2006

[Inactivation of failsafe programs by Twist oncoproteins and tumor progression].

scientific article published on 16 October 2008

[Role of the epithelial-mesenchymal transition during tumor progression]

scientific article published on 01 January 2010

[The catalytic subunit of the anaphase-promoting complex, APC11, is involved in CIN+ CRC progression]

scientific article published on 18 February 2019

[The enigma of the biological interpretation of the linear-quadratic model finally resolved? A summary for non-mathematicians].

scientific article

[The key implication of early migration of metastatic cells]

scientific article published on 01 January 2009

[The p53 gene in human hepatocarcinogenesis]

scientific article published on 01 January 1993

[The premature senescence: chimera, saving angel or Dr Jekyll and Mr Hyde?]

scientific article published on 01 February 2009

[Tumour genomics: an unstable landscape]

scientific article published on 01 October 2008

[microRNA in cancer, small but risky]

scientific article published on 01 February 2008

p21(Cip1) regulates cell-substrate adhesion and interphase microtubule dynamics in untransformed human mammary epithelial cells

scientific article published on 11 May 2011

p21(WAF1/CIP1) response to genotoxic agents in wild-type TP53 expressing breast primary tumours

scientific article published on 01 January 1997

p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.

scientific article published on September 2013

p53 as a growth suppressor gene in HBV-related hepatocellular carcinoma cells.

scientific article published on February 1993

p53 as a potential target in cancer therapy.

scientific article published on January 1992

p53 as a target for anti-cancer drug development.

scientific article

p53 induction prevents accumulation of aberrant transcripts in cancer cells

scientific article published on 01 January 2001

βIII-Tubulin is required for interphase microtubule dynamics in untransformed human mammary epithelial cells

scientific article published on 04 August 2011

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