List of works - David Colecchia

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy

scientific article published on 5 October 2018

Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B.

scientific article published on 13 November 2017

Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood-Brain Barrier

scientific article

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

scientific article published on 10 October 2015

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

scientific article

Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery

scientific article published on 22 February 2016

MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process

scientific article published in Journal of Biological Chemistry

MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation

scientific article published on 20 August 2015

MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors.

scientific article published on 14 March 2016

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins ⬇️

scientific article published on September 4, 2012

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

scientific article published on 12 January 2016

Straightforward synthesis of a novel ring-fused pyrazole-lactam and in vitro cytotoxic activity on cancer cell lines.

scientific article published on 05 April 2016

Structure prediction and validation of the ERK8 kinase domain

scientific article published on 11 January 2013

Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe

scientific article

List of works by David Colecchia

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy

Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B.

Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood-Brain Barrier

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery

MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process

MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation

MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors.

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins ⬇️

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

Straightforward synthesis of a novel ring-fused pyrazole-lactam and in vitro cytotoxic activity on cancer cell lines.

Structure prediction and validation of the ERK8 kinase domain

Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe