List of works - Eric Oldfield

"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

scientific article published on 7 December 2017

(57)Fe Mössbauer isomer shifts of heme protein model systems: electronic structure calculations

scientific article published on 01 July 2002

(67)Zn NMR chemical shifts and electric field gradients in zinc complexes: a quantum chemical investigation

scientific article

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

scientific article published in November 2003

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "Click" Reactions in Water and in Cells

scientific article published on 16 August 2016

A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery

scientific article

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

scientific article published on 19 March 2019

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

scientific article

A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin

scientific article

A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase.

scientific article published in January 2005

A density functional theory investigation of Fe-N-O bonding in heme proteins and model systems

scientific article published in December 2003

A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents

scientific article

A solid state 13C NMR, crystallographic, and quantum chemical investigation of chemical shifts and hydrogen bonding in histidine dipeptides

scientific article

A solid state 13C NMR, crystallographic, and quantum chemical investigation of phenylalanine and tyrosine residues in dipeptides and proteins

scientific article published on 17 May 2007

Activity of bisphosphonates against Trypanosoma brucei rhodesiense

scientific article published in July 2002

Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines

scientific article published on September 2006

Activity of sulfonium bisphosphonates on tumor cell lines

scientific article published on 27 October 2007

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).

scientific article published on 12 February 2018

Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole

scientific article published in February 2006

An ENDOR and HYSCORE Investigation of a Reaction Intermediate in IspG (GcpE) Catalysis ⬇️

scientific article published on May 16, 2011

An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs

scientific article published in July 2002

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

scientific article

Antibacterial drug leads targeting isoprenoid biosynthesis

scientific article

Antibacterial drug leads: DNA and enzyme multitargeting

scientific article published on 22 January 2015

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results.

scientific article published on 20 June 2017

Antiinfectives targeting enzymes and the proton motive force.

scientific article

Antiparasitic activity of risedronate in a murine model of acute Chagas' disease.

scientific article published in March 2004

Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target ⬇️

scientific article

Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition

scientific article published on 21 March 2019

Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.

scientific article published on 31 August 2016

Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer

scientific article

Bioorganometallic mechanism of action, and inhibition, of IspH

scientific article (publication date: 9 March 2010)

Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data

scientific article

Bisphosphonate inhibition of phosphoglycerate kinase: quantitative structure-activity relationship and pharmacophore modeling investigation

scientific article published on 01 November 2006

Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase.

scientific article

Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation

scientific article published on 27 August 2008

Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations

scientific article

Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.

scientific article

Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies

scientific article published in Journal of Biological Chemistry

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

scientific article

COVID-19 and Other Pandemics: How Might They Be Prevented?

scientific article published on 01 June 2020

Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP

scientific article

Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni

scientific article published on 16 September 2013

Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI.

scientific article

Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism

scientific article published on 02 March 2019

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase fromEscherichia colireveal the catalytic and chain-length determining mechanisms ⬇️

scientific article

Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei

scientific article published on 23 September 2004

Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes

scientific article published in September 2004

Cytochrome P450: an investigation of the Mössbauer spectra of a reaction intermediate and an Fe(IV)[double bond]O model system

scientific article published in April 2004

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis

scientific article published on 21 February 2019

Discovery of Prenyltransferase Inhibitors with In Vitro and In Vivo Antibacterial Activity

scientific article published on 21 October 2020

Discovery of acetylene hydratase activity of the iron–sulphur protein IspH

scientific article

Diterpene cyclases and the nature of the isoprene fold

scientific article (publication date: 15 August 2010)

Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy

scientific article published on 3 February 2014

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

scientific article

Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase

scientific article

Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo

scientific article published on January 2004

Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase

scientific article published in March 2006

Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

scientific article published on 02 December 2019

Farnesyl diphosphate synthase inhibitors from in silico screening

scientific article published on June 2013

Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries

scientific article

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies

scientific article published on 4 March 2003

HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis

scientific article

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

scientific article published on 24 March 2017

Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets ⬇️

scientific article published on May 10, 2012

In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates

scientific article published on 21 September 2015

In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei

scientific article

In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

scientific article

Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism

scientific article published on 19 October 2011

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation †

scientific article

Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109

scientific article published on 25 July 2016

Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus : In Vitro, in Vivo, and Crystallographic Results †

scientific article

Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.

scientific article published on January 2006

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents

scientific article

Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms

scientific article published on May 2010

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB fromBacillus subtilisandStaphylococcus aureus

scientific article

Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH

scientific article

Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes

scientific article

Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.

scientific article published on 30 August 2016

Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin

scientific article published in December 2006

IspH-RPS1 and IspH-UbiA: "Rosetta Stone" Proteins

scientific article published on 7 September 2015

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

scientific article

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

scientific article

Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth

scientific article

Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators

scientific article

Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible

scientific article published in July 2002

Mechanism of action and inhibition of dehydrosqualene synthase

scientific article

Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.

scientific article

Multitarget drug discovery for tuberculosis and other infectious diseases

scientific article

Mycobacterium tuberculosis releases an antacid that remodels phagosomes

scientific article published on 19 August 2019

Mössbauer quadrupole splittings and electronic structure in heme proteins and model systems: a density functional theory investigation

scientific article published on 01 November 2002

NMR hyperfine shifts in blue copper proteins: a quantum chemical investigation

scientific article published on 04 March 2008

NMR investigations of the static and dynamic structures of bisphosphonates on human bone: a molecular model

scientific article published on 4 January 2008

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design.

scientific article

Nuclear magnetic resonance shifts in paramagnetic metalloporphyrins and metalloproteins

scientific article published in November 2002

On the Mössbauer spectra of isopenicillin N synthase and a model (FeNO)7 (S = 3/2) system

scientific article

Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)

scientific article (publication date: 22 June 2010)

Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors

scientific article published on May 2015

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci.

scientific article published on March 2017

Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus

scientific article published on February 2009

Photoaffinity antigens for human gammadelta T cells

scientific article published on December 2008

Polyoxometalates functionalized by bisphosphonate ligands: synthesis, structural, magnetic, and spectroscopic characterizations and activity on tumor cell lines.

scientific article

Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line.

scientific article

Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.

scientific article

Pyridine Inhibitor Binding to the 4Fe-4S Protein A. aeolicus IspH (LytB): A HYSCORE Investigation ⬇️

scientific article published on April 12, 2011

Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.

scientific article published in April 2005

Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates

scientific article published on January 2004

Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate

scientific article published on 5 June 2002

Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

scientific article published on 12 February 2012

Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

scientific article published on 01 April 2015

Remarkable Similarity in Plasmodium falciparum and Plasmodium vivax Geranylgeranyl Diphosphate Synthase (GGPPS) Dynamics and its Implication for Anti-Malarial Drug Design.

scientific article published on 18 January 2018

SQ109, a new drug lead for Chagas disease

scientific article

Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi

scientific article

Solid-state NMR fermi contact and dipolar shifts in organometallic complexes and metalloporphyrins

article published in 2005

Solid-state NMR of a paramagnetic DIAD-FeII catalyst: sensitivity, resolution enhancement, and structure-based assignments

scientific article published in October 2006

Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes

article

Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors

scientific article published on 2 March 2017

Squalene synthase as a target for Chagas disease therapeutics

scientific article

Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production

scientific article

Structural and thermodynamic basis of the inhibition ofLeishmania majorfarnesyl diphosphate synthase by nitrogen-containing bisphosphonates

scientific article

Structural studies of Vgamma2Vdelta2 T cell phosphoantigens

scientific article

Structure and Function of Four Classes of the 4Fe-4S Protein, IspH.

scientific article published on 30 June 2016

Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase.

scientific article published on 29 February 2016

Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis

scientific article

Structure and mechanism of action of isopentenylpyrophosphate-dimethylallylpyrophosphate isomerase

scientific article (publication date: 19 March 2003)

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

scientific article

Structure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

scientific article

Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.

scientific article published on 26 July 2016

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

scientific article

Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH

scientific article

Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD(+) , NADPH, or NAD(+) /10-Oxogeranial: Reaction Mechanisms.

scientific article

Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets

scientific article published on 23 February 2016

Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases

scientific article

Synthesis of chiral phosphoantigens and their activity in gamma delta T cell stimulation.

scientific article published on September 2004

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site

scientific article

Terpene Biosynthesis: Modularity Rules ⬇️

scientific article published on November 21, 2011

Tetra‐ to Dodecanuclear Oxomolybdate Complexes with Functionalized Bisphosphonate Ligands: Activity in Killing Tumor Cells ⬇️

scientific article published on December 10, 2010

The ABCs (and Ds) of Class I Terpene Cyclase (αC), Trans- Head-to-Tail (αHT) and Head-to-Head (αHH) Prenyltransferase Structures and Mechanisms of Action

scientific article published on 7 November 2019

The H(+)-pyrophosphatase of Rhodospirillum rubrum is predominantly located in polyphosphate-rich acidocalcisomes

scientific article published on 15 September 2004

The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates

scientific article published on 27 August 2007

Thermodynamics of bisphosphonates binding to human bone: a two-site model

scientific article published on June 2009

Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads

scientific article

List of works by Eric Oldfield

"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

(57)Fe Mössbauer isomer shifts of heme protein model systems: electronic structure calculations

(67)Zn NMR chemical shifts and electric field gradients in zinc complexes: a quantum chemical investigation

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "Click" Reactions in Water and in Cells

A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin

A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase.

A density functional theory investigation of Fe-N-O bonding in heme proteins and model systems

A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents

A solid state 13C NMR, crystallographic, and quantum chemical investigation of chemical shifts and hydrogen bonding in histidine dipeptides

A solid state 13C NMR, crystallographic, and quantum chemical investigation of phenylalanine and tyrosine residues in dipeptides and proteins

Activity of bisphosphonates against Trypanosoma brucei rhodesiense

Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines

Activity of sulfonium bisphosphonates on tumor cell lines

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).

Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole

An ENDOR and HYSCORE Investigation of a Reaction Intermediate in IspG (GcpE) Catalysis ⬇️

An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

Antibacterial drug leads targeting isoprenoid biosynthesis

Antibacterial drug leads: DNA and enzyme multitargeting

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results.

Antiinfectives targeting enzymes and the proton motive force.

Antiparasitic activity of risedronate in a murine model of acute Chagas' disease.

Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target ⬇️

Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition

Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.

Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer

Bioorganometallic mechanism of action, and inhibition, of IspH

Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data

Bisphosphonate inhibition of phosphoglycerate kinase: quantitative structure-activity relationship and pharmacophore modeling investigation

Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase.

Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation

Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations

Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.

Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

COVID-19 and Other Pandemics: How Might They Be Prevented?

Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP

Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni

Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI.

Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase fromEscherichia colireveal the catalytic and chain-length determining mechanisms ⬇️

Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei

Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes

Cytochrome P450: an investigation of the Mössbauer spectra of a reaction intermediate and an Fe(IV)[double bond]O model system

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis

Discovery of Prenyltransferase Inhibitors with In Vitro and In Vivo Antibacterial Activity

Discovery of acetylene hydratase activity of the iron–sulphur protein IspH

Diterpene cyclases and the nature of the isoprene fold

Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase

Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo

Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase

Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

Farnesyl diphosphate synthase inhibitors from in silico screening

Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies

HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets ⬇️

In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates

In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei

In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation †

Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109

Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus : In Vitro, in Vivo, and Crystallographic Results †

Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents

Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB fromBacillus subtilisandStaphylococcus aureus

Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH

Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes

Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.