List of works - Naoki Umezawa

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

scientific article published on 01 January 2007

A fluorescence polarization assay for the identification of inhibitors of the p53-DM2 protein-protein interaction

scientific article published on 01 January 2002

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.

scientific article published on 10 July 2018

A versatile strategy for the synthesis of crown ether-bearing heterocycles: discovery of calcium-selective fluoroionophore

scientific article published on 22 August 2007

Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker.

scientific article published on 23 December 2016

Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2.

scientific article

Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine

scientific article published on 7 September 2017

Biogenic triamine and tetraamine activate core catalytic ability of Tetrahymena group I ribozyme in the absence of its large activator module

scientific article published on 12 January 2018

Branched-Chain Polyamine Found in Hyperthermophiles Induces Unique Temperature-Dependent Structural Changes in Genome-Size DNA

scientific article published on 10 July 2018

Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition

scientific article published on 01 August 2005

Comparative study of polyethylene polyamines as activator molecules for a structurally unstable group I ribozyme.

scientific article published on 26 April 2018

Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(iii) protoporphyrin IX and its application as a supramolecular photosensitizer

scientific article published on 31 August 2018

Design of New Extraction Surfactants for Membrane Proteins from Peptide Gemini Surfactants.

scientific article

Design, synthesis, and evaluation of new type of L-amino acids containing pyridine moiety as nitric oxide synthase inhibitor.

scientific article published on 8 February 2006

Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.

scientific article

Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol

scientific article published on 29 January 2020

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

scientific article published on 6 February 2013

Effect of the o-Acetamido Group on pH-Dependent Light Emission of a 3-Hydroxyphenyl-Substituted Dioxetane Luminophore

scientific article published on 15 February 2019

Enhanced catalase-like activity of manganese salen complexes in water: effect of a three-dimensionally fixed auxiliary

scientific article published on 09 October 2006

Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes.

scientific article published on 25 April 2005

Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

scientific article published on 01 January 2008

Facile synthesis of peptide-porphyrin conjugates: Towards artificial catalase.

scientific article published on 19 July 2010

Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles.

scientific article

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

scientific article published in June 2009

Interactions of the antimicrobial beta-peptide beta-17 with phospholipid vesicles differ from membrane interactions of magainins

scientific article published on 01 March 2003

Manganese salen complexes with acid-base catalytic auxiliary: functional mimetics of catalase

scientific article published on 12 March 2013

Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst

scientific article published on 24 June 2019

Naturally occurring branched-chain polyamines induce a crosslinked meshwork structure in a giant DNA.

scientific article published on December 2016

Nitrous oxide reduction-coupled alkene-alkene coupling catalysed by metalloporphyrins.

scientific article published in October 2013

Novel probes showing specific fluorescence enhancement on binding to a hexahistidine tag.

scientific article published in January 2008

On-bead fluorescence assay for serine/threonine kinases

scientific article published on 01 December 2005

Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents

scientific article published on 01 June 1997

Photocontrol of Peptide function: backbone cyclization strategy with photocleavable amino Acid.

scientific article published on 7 June 2011

Rational design of fluorescein-based fluorescence probes. Mechanism-based design of a maximum fluorescence probe for singlet oxygen.

scientific article published in March 2001

Role of Thiolate Ligand in Spin State and Redox Switching in the Cytochrome P450 Catalytic Cycle.

scientific article published on 28 March 2017

Selective Binding of TAR RNA by a Tat-Derived β-Peptide

scientific article published on 01 October 2003

Selective recognition and detection of biomacromolecules utilizing chemical property of amino Acid or Peptide

scientific article published in December 2007

Stable Iron Porphyrin Intramolecularly Coordinated by Alcoholate Anion: Synthesis and Evaluation of Axial Ligand Effect of Alcoholate on Spectroscopy and Catalytic Activity

scientific article published on 21 March 2019

Structurally Diverse Polyamines: Solid-Phase Synthesis and Interaction with DNA

scientific article published on 16 July 2015

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

scientific article

Synthesis of the carbon framework of scholarisine A by intramolecular oxidative coupling.

scientific article published on 11 February 2013

Translocation of a beta-peptide across cell membranes

scientific article published in January 2002

Unique oxidation reaction of amides with pyridine-N-oxide catalyzed by ruthenium porphyrin: direct oxidative conversion of N-acyl-L-proline to N-acyl-L-glutamate.

scientific article published in January 2005

List of works by Naoki Umezawa

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

A fluorescence polarization assay for the identification of inhibitors of the p53-DM2 protein-protein interaction

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.

A versatile strategy for the synthesis of crown ether-bearing heterocycles: discovery of calcium-selective fluoroionophore

Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker.

Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2.

Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine

Biogenic triamine and tetraamine activate core catalytic ability of Tetrahymena group I ribozyme in the absence of its large activator module

Branched-Chain Polyamine Found in Hyperthermophiles Induces Unique Temperature-Dependent Structural Changes in Genome-Size DNA

Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition

Comparative study of polyethylene polyamines as activator molecules for a structurally unstable group I ribozyme.

Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(iii) protoporphyrin IX and its application as a supramolecular photosensitizer

Design of New Extraction Surfactants for Membrane Proteins from Peptide Gemini Surfactants.

Design, synthesis, and evaluation of new type of L-amino acids containing pyridine moiety as nitric oxide synthase inhibitor.

Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.

Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

Effect of the o-Acetamido Group on pH-Dependent Light Emission of a 3-Hydroxyphenyl-Substituted Dioxetane Luminophore

Enhanced catalase-like activity of manganese salen complexes in water: effect of a three-dimensionally fixed auxiliary

Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes.

Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

Facile synthesis of peptide-porphyrin conjugates: Towards artificial catalase.

Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles.

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

Interactions of the antimicrobial beta-peptide beta-17 with phospholipid vesicles differ from membrane interactions of magainins

Manganese salen complexes with acid-base catalytic auxiliary: functional mimetics of catalase

Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst

Naturally occurring branched-chain polyamines induce a crosslinked meshwork structure in a giant DNA.

Nitrous oxide reduction-coupled alkene-alkene coupling catalysed by metalloporphyrins.

Novel probes showing specific fluorescence enhancement on binding to a hexahistidine tag.

On-bead fluorescence assay for serine/threonine kinases

Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents

Photocontrol of Peptide function: backbone cyclization strategy with photocleavable amino Acid.

Rational design of fluorescein-based fluorescence probes. Mechanism-based design of a maximum fluorescence probe for singlet oxygen.

Role of Thiolate Ligand in Spin State and Redox Switching in the Cytochrome P450 Catalytic Cycle.

Selective Binding of TAR RNA by a Tat-Derived β-Peptide

Selective recognition and detection of biomacromolecules utilizing chemical property of amino Acid or Peptide

Stable Iron Porphyrin Intramolecularly Coordinated by Alcoholate Anion: Synthesis and Evaluation of Axial Ligand Effect of Alcoholate on Spectroscopy and Catalytic Activity

Structurally Diverse Polyamines: Solid-Phase Synthesis and Interaction with DNA

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

Synthesis of the carbon framework of scholarisine A by intramolecular oxidative coupling.

Translocation of a beta-peptide across cell membranes

Unique oxidation reaction of amides with pyridine-N-oxide catalyzed by ruthenium porphyrin: direct oxidative conversion of N-acyl-L-proline to N-acyl-L-glutamate.