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List of works by Adrián Llerena

A Pharmacovigilance Study in First Episode of Psychosis: Psychopharmacological Interventions and Safety Profiles in the PEPs Project.

scientific article published on 27 October 2015

A combined high CYP2D6-CYP2C19 metabolic capacity is associated with the severity of suicide attempt as measured by objective circumstances.

scientific article published on 12 August 2014

A rapid and simple LC–MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity

scientific article published on 01 March 2014

A tribute to josé maría ("chema") cantú.

scientific article published on March 2014

ABCB1 gene polymorphisms and violent suicide attempt among survivors.

scientific article

ATA homozigosity in the IL-10gene promoter is a risk factor for schizophrenia in Spanish females: a case control study ⬇️

scientific article published on June 9, 2011

Acetylator polymorphism in Parkinson's disease

scientific article published on 01 January 1989

Allele and genotype frequencies of genes relevant to anti-epileptic drug therapy in Mexican-Mestizo healthy volunteers

scientific article published on 28 October 2016

An Appeal to the Global Health Community for a Tripartite Innovation: An "Essential Diagnostics List," "Health in All Policies," and "See-Through 21(st) Century Science and Ethics".

scientific article

An Open Letter in Support of Transformative Biotechnology and Social Innovation: SANKO University Innovation Summit in Medicine and Integrative Biology, Gaziantep, Turkey, May 5-7, 2016.

scientific article published in April 2016

Analysis of diclofenac and its metabolites by high-performance liquid chromatography: relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios.

scientific article published in June 2003

Antipsychotic drugs and QTc prolongation: the potential role of CYP2D6 genetic polymorphism.

scientific article published on February 2007

Aripiprazole-induced parkinsonism and its association with dopamine and serotonin receptor polymorphisms.

scientific article published in June 2008

Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis.

scientific article published in March 1989

Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs.

scientific article

Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population ⬇️

scientific article published on January 3, 2012

CYP2C9 allele frequency differences between populations of Mexican-Mestizo, Mexican-Tepehuano, and Spaniards.

scientific article

CYP2C9 gene and susceptibility to major depressive disorder.

scientific article published in January 2003

CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy

scientific article published on 30 June 2015

CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico

article

CYP2D6 genetic polymorphism and psychiatry patients' hospitalization period

scientific article published in December 2013

CYP2D6 genetic polymorphisms in Southern Mexican Mayan Lacandones and Mestizos from Chiapas

scientific article published on January 2014

CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans

scientific article published on 07 December 2010

CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population

scientific article published on 15 November 2011

CYP2D6 polymorphism and mental and personality disorders in suicide attempters

scientific article published in December 2014

CYP2D6 polymorphism in patients with eating disorders

scientific article published on 28 September 2010

CYP2D6 poor metabolizer status might be associated with better response to risperidone treatment

scientific article published in November 2013

CYP2D6 variation, behaviour and psychopathology: implications for pharmacogenomics-guided clinical trials

scientific article published on April 2014

CYP2D6Polymorphism and Mental and Personality Disorders in Suicide Attempters

article published in 2013

CYP450 genotype and pharmacogenetic association studies: a critical appraisal

article

Characterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: pharmacogenetic implications

article

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

scientific article published on 29 June 2015

Clinical drug-drug interactions: focus on venlafaxine.

scientific article published on March 2015

Clinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs.

scientific article published on December 2006

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

scientific article published in November 1994

Clozapine withdrawal symptoms after change to sertindole in a schizophrenic patient

scientific article published on 01 January 2000

Cumplimiento farmacológico en el tratamiento de la hipertensión arterial. Revisión de los estudios publicados entre los años 1975 y 2011

scientific article published on 11 April 2012

Cytochrome P450 genetic polymorphisms of Mexican indigenous populations.

scientific article published on January 2013

DEBRISOQUINE HYDROXYLATION PHENOTYPES IN HEALTHY VOLUNTEERS

scientific article published in The Lancet

Debrisoquin and mephenytoin hydroxylation phenotypes and CYP2D6 genotype in patients treated with neuroleptic and antidepressant agents

scientific article published on 01 December 1993

Debrisoquine oxidation in schizophrenic patients treated with neuroleptics

Determination of clozapine and its N-desmethyl metabolite by high-performance liquid chromatography with ultraviolet detection

scientific article

Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship

scientific article

Determination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients.

scientific article

Determination of risperidone and 9-hydroxyrisperidone in human plasma by liquid chromatography: application to the evaluation of CYP2D6 drug interactions.

scientific article

Development of a HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hydroxylation phenotypes ⬇️

scientific article published on January 1, 2012

Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use

scientific article published on 01 October 2005

Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use.

scientific article

Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms

scientific article

Disposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation.

scientific article published on January 1993

Editorial [Hot Topic: Pharmacogenetic and Pharmacogenomics (Guest Editors: A. LLerena and J. Licinio) ]

scientific article published on 01 December 2006

Editorial: CPPM 2013 Onward: Building a Socio-Technical GPS for Global Personalized Medicine – A Welcome to Editors-In-Chief Adrian LLerena (Spain) and Ross A. McKinnon (Australia)

article

Effect of CYP2D6 and CYP2C9 genotypes on fluoxetine and norfluoxetine plasma concentrations during steady-state conditions.

scientific article

Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.

scientific article published in December 2001

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment

scientific article published on 29 November 2016

Erratum to: “Schizophrenia and tobacco smoking in a Spanish psychiatric hospital” [Schizophr. Res. 58 (2002) 323–327]

article

Erratum: CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients

scholarly article published in Molecular Psychiatry

Estudio farmacogenético del polimorfismo metabólico de la debrisoquina (CYP2D6) en la población cubana en relación con la española

scientific article published on 01 May 2007

Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans

scientific article published on December 2014

Evaluating a newly developed pharmacogenetic array: screening in a Spanish population.

scientific article published on November 2010

Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis.

scientific article

First MEPS/HPLC assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma

scientific article published on 01 January 2014

Fixed combinations of neuroleptics with antidepressants: potential risks and estimation of use.

scientific article

Frequency of S-mephenytoin hydroxylation deficiency in 373 spanish subjects compared to other Caucasian populations

article

Genetic variability of CYP2C9*2 and CYP2C9*3 in seven indigenous groups from Mexico.

scientific article published on 28 October 2016

Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype

scientific article published on April 1, 1992

Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers

scientific article published on June 1, 1992

High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme

High frequency of CYP2D6 ultrarapid metabolizer genotypes in an Ashkenazi Jewish population from Argentina.

scientific article

High frequency of CYP2D6 ultrarapid metabolizers in Spain: controversy about their misclassification in worldwide population studies.

scientific article published on 7 June 2016

High prevalence of CYP2D6 ultrarapid metabolizers in a mestizo Colombian population in relation to Hispanic mestizo populations

scientific article published on 30 October 2020

High-performance liquid chromatography method using ultraviolet detection for the quantification of aripiprazole and dehydroaripiprazole in psychiatric patients.

scientific article published in January 2012

Impact of cytochrome P450 genes on suicide attempt and risk.

scientific article published on 16 March 2013

Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele

scientific article published on 01 August 2007

Influence of CYP2D6 deletion, multiplication, -1584C-->G, 31G-->A and 2988G-->a gene polymorphisms on dextromethorphan metabolism among Mexican tepehuanos and mestizos.

scientific article published on 30 June 2010

Influence of admixture components on CYP2C9*2 allele frequency in eight indigenous populations from Northwest Mexico.

scientific article

Interethnic differences in UGT1A4 genetic polymorphisms between Mexican Mestizo and Spanish populations.

scientific article

Interethnic relationships of CYP2D6 variants in native and Mestizo populations sharing the same ecosystem.

scientific article

Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations.

scientific article

Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: a report from the RIBEF (Ibero-American Network of Pharmacogenetics and Pharmacogenomics)

scientific article published on 01 June 2016

Interethnic variation of CYP2C19 alleles, 'predicted' phenotypes and 'measured' metabolic phenotypes across world populations.

scientific article

Intuitive pharmacogenetic dosing of risperidone according to CYP2D6 phenotype extrapolated from genotype in a cohort of first episode psychosis patients

scientific article

La Tertulia del Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo

scientific article published on 01 March 2008

Liver enzyme abnormalities during antipsychotic treatment: a case report of risperidone-associated hepatotoxicity

scientific article published on 01 January 2014

Losartan hydroxylation phenotype in an Ecuadorian population: influence of CYP2C9 genetic polymorphism, habits and gender

Low frequency of CYP2D6 poor metabolizers among schizophrenia patients

article

Lower frequency of CYP2C9*2 in Mexican-Americans compared to Spaniards.

scientific article published in January 2004

MDR-1 genotypes and quetiapine pharmacokinetics in healthy volunteers.

scientific article published in January 2013

Metabolic phenotype prediction from genotyping data: a bottleneck for the implementation of pharmacogenetics in drug development and clinical practice.

scientific article

Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe ⬇️

scientific article published on August 1, 1997

Multiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach.

scientific article published on 24 November 2015

Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms

article

Oxidative polymorphism of debrisoquine in Parkinson's disease

scientific article

Patterns of drug treatment of schizophrenic patients in Estonia, Spain and Sweden

scientific article

Pharmacogenetic Studies of Suicide: Potential Relevance of Main Polymorphic CYPs and ABCB1

Pharmacogenetic potential biomarkers for carbamazepine adverse drug reactions and clinical response.

scientific article published on January 2014

Pharmacogenetic research activity in Central America and the Caribbean: a systematic review

scientific article published on 16 September 2016

Pharmacogenetic study of antipsychotic induced acute extrapyramidal symptoms in a first episode psychosis cohort: role of dopamine, serotonin and glutamate candidate genes

scientific article published on 7 June 2016

Pharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America.

scientific article published on 28 October 2016

Pharmacogenetics and therapeutic drug monitoring of fluoxetine in a real-world setting: A PK/PD analysis of the influence of (non-)genetic factors

scientific article published on 21 November 2019

Pharmacogenetics in Central American healthy volunteers: interethnic variability

scientific article published on March 2015

Pharmacogenetics in Latin American populations: regulatory aspects, application to herbal medicine, cardiovascular and psychiatric disorders ⬇️

scientific article published on January 1, 2012

Pharmacogenetics of adverse reactions to antiepileptic drugs.

scientific article published on 11 May 2015

Pharmacogenetics of clinical response to risperidone.

scientific article published on January 2013

Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity.

scientific article

Pharmacogenetics of the antiepileptic drugs phenytoin and lamotrigine.

scientific article published on January 2011

Pharmacogenomic information in drug labels: European Medicines Agency perspective.

scientific article

Pharmacogenomics and Personality: Role of CYP2D6 and Implications for Psychopathology

article published in 2010

Pharmacogenomics and personalized medicine in clinical practice

scientific article published on 01 May 2011

Pharmacogenomics education: International Society of Pharmacogenomics recommendations for medical, pharmaceutical, and health schools deans of education.

scientific article

Pharmacogenomics in pain treatment

scientific article published on September 2016

Pharmacokinetic Interaction of Fluvoxamine and Thioridazine in Schizophrenic Patients

scientific article published on 01 December 1999

Polymorphic Oxidation of Debrisoquine in Bladder Cancer

scientific article published on 01 June 1990

Polymorphic oxidation of debrisoquine in lung cancer patients

scientific article published on 01 January 1991

Polymorphic oxidation of debrisoquine in women with breast cancer

scientific article published on 01 January 1991

Population pharmacogenetics and global health

article

Population pharmacogenetics of Ibero-Latinoamerican populations (MESTIFAR 2014)

scientific article published on 01 May 2015

Predictive biomarkers candidates for patients with metastatic colorectal cancer treated with bevacizumab-containing regimen.

scientific article published on 14 March 2016

Present status and perspective of pharmacogenetics in Mexico

scientific article published on January 2014

Progress in pharmacogenetics: consortiums and new strategies

scientific article

QTc interval lengthening and debrisoquine metabolic ratio in psychiatric patients treated with oral haloperidol monotherapy.

scientific article published in June 2002

QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients

scientific article

QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations.

scientific article

Ready to put metadata on the post-2015 development agenda? Linking data publications to responsible innovation and science diplomacy

scientific article published in January 2014

Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics, and clinical outcomes: GnG-PK/PD-AD study

scientific article published on 23 May 2019

References used in a Drug Information Centre

scientific article published on 01 January 1995

Relationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients.

scientific article published in March 2004

Relationship between personality and debrisoquine hydroxylation capacity

article

Relationship between the CYP2C9 IVS8-109A>T polymorphism and high losartan hydroxylation in healthy Ecuadorian volunteers

scientific article published on 01 August 2014

Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population

scientific article published on 06 October 2020

Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients.

scientific article published in July 2009

Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population

Reproducibility over Time of Mephenytoin and Debrisoquine Hydroxylation Phenotypes

scientific article published on 01 July 1993

Reproducibility over time of the urinary diclofenac/4'-OH diclofenac ratio among different CYP2C9 genotypes

scientific article published in July 2003

Research Highlights

scientific article published on 01 April 2013

Research Highlights

Research Highlights: Novel CYP2C9 genetic polymorphisms and assessment of their impact on hydroxylation capacity

scientific article published on 01 February 2014

Schizophrenia and tobacco smoking in a Spanish psychiatric hospital.

scientific article published in December 2002

Schizophrenia and tobacco smoking in a Spanish psychiatric hospital.

scientific article published in April 2003

Schizophrenia stigma among medical and nursing undergraduates

scientific article published on 01 September 2002

Simultaneous Determination of Cytochrome P450 Oxidation Capacity in Humans: A Review on the Phenotyping Cocktail Approach.

scientific article published on 26 September 2016

Strengths and weaknesses of pharmacogenetic studies of antipsychotic drugs: the potential value of the PEPs study.

scientific article

Success stories in genomic medicine from resource-limited countries

scientific article published on 18 June 2015

The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans

scientific article

The Underlying Traits of the Karolinska Scales of Personality (KSP)

The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients

scientific article published on 13 November 2020

Therapeutic Drug Monitoring of Fluoxetine, Norfluoxetine and Paroxetine: A New Tool Based on Microextraction by Packed Sorbent Coupled to Liquid Chromatography

scientific article published in September 2017

Third Santorini conference pharmacogenomics workshop report: “Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?”

scientific article published on 01 January 2007

To Genotype or Phenotype for Personalized Medicine? CYP450 Drug Metabolizing Enzyme Genotype-Phenotype Concordance and Discordance in the Ecuadorian Population

scientific article published on 16 November 2016

Translating biotechnology to knowledge-based innovation, peace, and development? Deploy a Science Peace Corps--an open letter to world leaders

scientific article

Use of pharmacogenetics in bioequivalence studies to reduce sample size: an example with mirtazapine and CYP2D6.

scientific article published on 26 June 2012

Use of the Mesoridazine/Thioridazine Ratio as a Marker for CYP2D6 Enzyme Activity

scientific article published on 01 August 2000

Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers

scientific article published on January 2014

What is the future of pharmacogenomics in pain management?

scientific article published on 19 December 2016

Worldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes.

scientific article

[Interaction between prajmaline and metoprotol: a possible pharmacogenetic explanation]

scientific article published on 01 April 1997

[Optimizing pharmacologic therapy for the elderly]

scientific article published on 01 September 2001

[Prevalence of polydipsia and water intoxication in psychiatric inpatients]

scientific article published on 01 September 2001

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