List of works - Michael W Pennington

(99m)Tc-Galacto-RGD2: a novel 99mTc-labeled cyclic RGD peptide dimer useful for tumor imaging.

scientific article published on 06 August 2013

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

scientific article

A continuous fluorescence-based assay of human cytomegalovirus protease using a peptide substrate

scientific article published on 01 May 1995

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

scientific article

A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

scientific article

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

scientific article

Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases

scientific article

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections

scientific article

Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

scientific article

Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes

scientific article

Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

scientific article

Comparison of inhibitor binding to feline and human immunodeficiency virus proteases: structure-based drug design and the resistance problem

scientific article

Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7.

scientific article published on 23 December 2019

Corrigendum to "Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK" [Peptides 99 (2018) 169-178].

scientific article published on 17 January 2018

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.

scientific article

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

scientific article published on 16 June 2017

Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

scientific article

Enabling Noninvasive Systemic Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] via the Buccal Mucosa

scientific article published on 13 June 2016

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

scientific article

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

scientific article published on 21 May 2018

Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain

scientific article

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

scientific article

Ionisation behaviour and solution properties of the potassium-channel blocker ShK toxin

scientific article published on 01 January 1998

Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthus

scientific article published on 01 April 1989

K+ channels as targets for specific immunomodulation

scientific article

KCa1.1 channels regulate β1-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes

scientific article published on 20 April 2017

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

scientific article

Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.

scientific article

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

scientific article published on 23 April 2015

Noncompetitive inhibition of N-methyl-D-aspartate by conantokin-G: evidence for an allosteric interaction at polyamine sites

scientific article published on October 1, 1992

Peptide therapeutics from venom: Current status and potential.

scientific article published on 23 September 2017

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases

scientific article

Potassium channel modulation by a toxin domain in matrix metalloprotease 23

scientific article

Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants.

scientific article published in September 2001

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

scientific article published on 4 April 2017

Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases.

scientific article published on 12 January 2016

Reinvestigation of the biological activity of d-allo-ShK protein

scientific article published on 8 June 2017

ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide

scientific article

Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin

scientific article (publication date: 30 July 1999)

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK.

scientific article published on 6 October 2017

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

scientific article

Synthesis and characterization of a disulfide bond isomer of omega-conotoxin GVIA

scientific article published on July 1, 1992

Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin

scientific article published on 01 January 1996

Synthesis of the cardiac inotropic polypeptide anthopleurin-A

scientific article published on 01 May 1994

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

scientific article published on 19 May 2018

Targeted tyrosine iodination in a multi-tyrosine vasopressin analog

scientific article published on 01 November 2007

Targeting KCa1.1 channels with a scorpion venom peptide for the therapy of rat models of rheumatoid arthritis.

scientific article published on 16 February 2018

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases

scientific article

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

scientific article

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

scientific article published on 24 April 2017

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

scientific article published on 18 June 2003

Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin

scientific article published on 01 November 1993

Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl

scientific article published on 07 February 2014

List of works by Michael W Pennington

(99m)Tc-Galacto-RGD2: a novel 99mTc-labeled cyclic RGD peptide dimer useful for tumor imaging.

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

A continuous fluorescence-based assay of human cytomegalovirus protease using a peptide substrate

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections

Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes

Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

Comparison of inhibitor binding to feline and human immunodeficiency virus proteases: structure-based drug design and the resistance problem

Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7.

Corrigendum to "Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK" [Peptides 99 (2018) 169-178].

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

Enabling Noninvasive Systemic Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] via the Buccal Mucosa

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

Ionisation behaviour and solution properties of the potassium-channel blocker ShK toxin

Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthus

K+ channels as targets for specific immunomodulation

KCa1.1 channels regulate β1-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

Noncompetitive inhibition of N-methyl-D-aspartate by conantokin-G: evidence for an allosteric interaction at polyamine sites

Peptide therapeutics from venom: Current status and potential.

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases

Potassium channel modulation by a toxin domain in matrix metalloprotease 23

Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants.

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases.

Reinvestigation of the biological activity of d-allo-ShK protein

ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide

Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK.

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

Synthesis and characterization of a disulfide bond isomer of omega-conotoxin GVIA

Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin

Synthesis of the cardiac inotropic polypeptide anthopleurin-A

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

Targeted tyrosine iodination in a multi-tyrosine vasopressin analog

Targeting KCa1.1 channels with a scorpion venom peptide for the therapy of rat models of rheumatoid arthritis.

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin

Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl