List of works - Stefano Fais

Adoptive transfer of an anti-MART-12735-specific CD8+ T cell clone leads to immunoselection of human melanoma antigen-loss variants in SCID mice

scientific article published on 01 February 2003

Antibody to ICAM-1 mediates enhancement of HIV-1 infection of human endothelial cells

article

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.

scientific article

Autophagy is a protective mechanism for human melanoma cells under acidic stress

scientific article

Biological properties of extracellular vesicles and their physiological functions.

scientific article published on 14 May 2015

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

scientific article

CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4+T lymphocytes

article

Cancer Cell Cannibalism: A Primeval Option to Survive.

scientific article

Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells

scientific article published on April 2006

Cannibalism: a way to feed on metastatic tumors

scientific article

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

scientific article

Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes.

scientific article

Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120

scientific article (publication date: October 1993)

Death Receptor-Induced Apoptosis Signalling Regulation by Ezrin Is Cell Type Dependent and Occurs in a DISC-Independent Manner in Colon Cancer Cells

scientific article published on 26 May 2015

Detection of exosomal prions in blood by immunochemistry techniques

scientific article published on 24 March 2015

Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells

scientific article published on 01 November 2002

Electrochemotherapy as First Line Cancer Treatment: Experiences from Veterinary Medicine in Developing Novel Protocols

scientific article published on January 2015

Erratum to: Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer

scientific article

Erratum to: microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy

scientific article published in March 2015

Escape strategies and reasons for failure in the interaction between tumour cells and the immune system: how can we tilt the balance towards immune-mediated cancer control?

scientific article

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

scientific article

Evidence-based support for the use of proton pump inhibitors in cancer therapy

scientific article

Exosomal clusterin, identified in the pericardial fluid, improves myocardial performance following MI through epicardial activation, enhanced arteriogenesis and reduced apoptosis.

scientific article published on 14 June 2015

Exosome levels in human body fluids: A tumor marker by themselves?

scientific article published on 14 September 2016

Exosome release and low pH belong to a framework of resistance of human melanoma cells to cisplatin

scientific article (publication date: 2014)

Exosomes released in vitro from Epstein–Barr virus (EBV)-infected cells contain EBV-encoded latent phase mRNAs ⬇️

scientific article published on May 16, 2013

Exosomes: the future of biomarkers in medicine

scientific article

Exosomes: the ideal nanovectors for biodelivery.

scientific article published on January 2013

Expression of CCR-7, MIP-3beta , and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities

scientific article published on 01 November 2001

Extracellular vesicles as shuttles of tumor biomarkers and anti-tumor drugs

scientific article

HIV type 1 grown on interferon gamma-treated U937 cells shows selective increase in virion-associated intercellular adhesion molecule 1 and HLA-DR and enhanced infectivity for CD4-negative cells.

scientific article

Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery

scientific article

High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors

scientific article

High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients

scientific article

Host cell antigenic profile acquired by HIV-1 is a marker of its cellular origin.

scientific article published on January 1995

Human Colorectal Cancer Cells Induce T-Cell Death Through Release of Proapoptotic Microvesicles: Role in Immune Escape

scientific article published on 01 June 2005

Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection.

scientific article published on April 1999

Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes

scientific article published on September 2006

Identification and Relevance of the CD95-binding Domain in the N-terminal Region of Ezrin

scientific article published in Journal of Biological Chemistry

Immune surveillance properties of human NK cell-derived exosomes.

scientific article published on 17 August 2012

Immunity to cancer: attack and escape in T lymphocyte-tumor cell interaction

scientific article

Importance of the state of activation and/or differentiation of CD4+ T cells in AIDS pathogenesis

scientific article published on 01 March 2002

Inability of normal human intestinal macrophages to form multinucleated giant cells in response to cytokines.

scientific article published on December 1995

Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.

scientific article

Interferon expression in Crohn's disease patients: increased interferon-gamma and -alpha mRNA in the intestinal lamina propria mononuclear cells

scientific article published on 01 October 1994

Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer

scientific article

Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

scientific article published on 28 December 2011

Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma

article published in 2015

Leukocyte uropod formation and membrane/cytoskeleton linkage in immune interactions ⬇️

scientific article published on May 1, 2003

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

article

Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach.

scientific article published on 22 August 2015

Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy

scientific article

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes.

scientific article

More insights into the immunosuppressive potential of tumor exosomes.

scientific article published on 30 October 2008

Moulding the shape of a metastatic cell

scientific article published on 01 March 2010

Murine granulocytes control human tumor growth in SCID mice.

scientific article published in August 2000

Murine interferon-alpha1 gene-transduced ESb tumor cells are rejected by host-mediated mechanisms despite resistance of the parental tumor to interferon-alpha/beta therapy.

scientific article published in May 1999

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.

scientific article

P-glycoprotein–actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin ⬇️

scientific article published on January 15, 2002

Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH

scientific article published on 01 December 2020

Pleiotropic function of ezrin in human metastatic melanomas.

scientific article published in June 2009

Potent phagocytic activity discriminates metastatic and primary human malignant melanomas: a key role of ezrin

scientific article published on November 2003

Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity

scientific article published on 01 December 2019

Proton channels and exchangers in cancer

scientific article

Proton dynamics in cancer

scientific article published on 15 June 2010

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

scientific article

Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed

scientific article published on 24 October 2013

Proton pump inhibitors as anti vacuolar-ATPases drugs: a novel anticancer strategy.

scientific article published on 08 May 2010

Proton pump inhibitors for the treatment of cancer in companion animals.

scientific article

Proton pump inhibitors induce a caspase-independent antitumor effect against human multiple myeloma.

scientific article published on 12 April 2016

Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species.

scientific article published on June 2007

Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect.

scientific article published on 28 May 2015

Soma-to-germline transmission of RNA in mice xenografted with human tumour cells: possible transport by exosomes

scientific article

TM9 and cannibalism: how to learn more about cancer by studying amoebae and invertebrates ⬇️

scientific article published on October 14, 2011

TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells

scientific journal article

The Janus-faced role of ezrin in "linking" cells to either normal or metastatic phenotype.

scientific article

The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors.

scientific article published on January 2013

The biological relevance of polykaryons in the immune response ⬇️

scientific article published on November 1, 1997

The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells.

scientific article published on 19 December 2015

The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells

scientific journal article

The key role of extracellular vesicles in the metastatic process.

scientific article published on 23 November 2017

Tumor acidity, chemoresistance and proton pump inhibitors.

scientific article

Tumour-released exosomes and their implications in cancer immunity.

scientific article published on 12 October 2007

U937-SCID mouse xenografts: a new model for acute in vivo HIV-1 infection suitable to test antiviral strategies

article

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

scientific article published on July 2010

List of works by Stefano Fais

Adoptive transfer of an anti-MART-12735-specific CD8+ T cell clone leads to immunoselection of human melanoma antigen-loss variants in SCID mice

Antibody to ICAM-1 mediates enhancement of HIV-1 infection of human endothelial cells

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.

Autophagy is a protective mechanism for human melanoma cells under acidic stress

Biological properties of extracellular vesicles and their physiological functions.

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4+T lymphocytes

Cancer Cell Cannibalism: A Primeval Option to Survive.

Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells

Cannibalism: a way to feed on metastatic tumors

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes.

Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120

Death Receptor-Induced Apoptosis Signalling Regulation by Ezrin Is Cell Type Dependent and Occurs in a DISC-Independent Manner in Colon Cancer Cells

Detection of exosomal prions in blood by immunochemistry techniques

Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells

Electrochemotherapy as First Line Cancer Treatment: Experiences from Veterinary Medicine in Developing Novel Protocols

Erratum to: Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer

Erratum to: microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy

Escape strategies and reasons for failure in the interaction between tumour cells and the immune system: how can we tilt the balance towards immune-mediated cancer control?

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

Evidence-based support for the use of proton pump inhibitors in cancer therapy

Exosomal clusterin, identified in the pericardial fluid, improves myocardial performance following MI through epicardial activation, enhanced arteriogenesis and reduced apoptosis.

Exosome levels in human body fluids: A tumor marker by themselves?

Exosome release and low pH belong to a framework of resistance of human melanoma cells to cisplatin

Exosomes released in vitro from Epstein–Barr virus (EBV)-infected cells contain EBV-encoded latent phase mRNAs ⬇️

Exosomes: the future of biomarkers in medicine

Exosomes: the ideal nanovectors for biodelivery.

Expression of CCR-7, MIP-3beta , and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities

Extracellular vesicles as shuttles of tumor biomarkers and anti-tumor drugs

HIV type 1 grown on interferon gamma-treated U937 cells shows selective increase in virion-associated intercellular adhesion molecule 1 and HLA-DR and enhanced infectivity for CD4-negative cells.

Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery

High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors

High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients

Host cell antigenic profile acquired by HIV-1 is a marker of its cellular origin.

Human Colorectal Cancer Cells Induce T-Cell Death Through Release of Proapoptotic Microvesicles: Role in Immune Escape

Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection.

Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes

Identification and Relevance of the CD95-binding Domain in the N-terminal Region of Ezrin

Immune surveillance properties of human NK cell-derived exosomes.

Immunity to cancer: attack and escape in T lymphocyte-tumor cell interaction

Importance of the state of activation and/or differentiation of CD4+ T cells in AIDS pathogenesis

Inability of normal human intestinal macrophages to form multinucleated giant cells in response to cytokines.

Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.

Interferon expression in Crohn's disease patients: increased interferon-gamma and -alpha mRNA in the intestinal lamina propria mononuclear cells

Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer

Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma

Leukocyte uropod formation and membrane/cytoskeleton linkage in immune interactions ⬇️

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach.

Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes.

More insights into the immunosuppressive potential of tumor exosomes.

Moulding the shape of a metastatic cell

Murine granulocytes control human tumor growth in SCID mice.

Murine interferon-alpha1 gene-transduced ESb tumor cells are rejected by host-mediated mechanisms despite resistance of the parental tumor to interferon-alpha/beta therapy.

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.

P-glycoprotein–actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin ⬇️

Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH

Pleiotropic function of ezrin in human metastatic melanomas.

Potent phagocytic activity discriminates metastatic and primary human malignant melanomas: a key role of ezrin

Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity

Proton channels and exchangers in cancer

Proton dynamics in cancer

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed

Proton pump inhibitors as anti vacuolar-ATPases drugs: a novel anticancer strategy.

Proton pump inhibitors for the treatment of cancer in companion animals.

Proton pump inhibitors induce a caspase-independent antitumor effect against human multiple myeloma.

Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species.

Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect.

Soma-to-germline transmission of RNA in mice xenografted with human tumour cells: possible transport by exosomes

TM9 and cannibalism: how to learn more about cancer by studying amoebae and invertebrates ⬇️

TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells

The Janus-faced role of ezrin in "linking" cells to either normal or metastatic phenotype.

The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors.

The biological relevance of polykaryons in the immune response ⬇️

The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells.