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List of works by Edwin R Chilvers

99mTechnetium-labelled neutrophil scanning in pneumonia.

scientific article

A case of refractory hypoxaemia.

scientific article

A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca(2+)-activated K+ channels in bovine tracheal smooth muscle cells in culture.

scientific article published on September 1995

A novel RASA1 mutation causing capillary malformation-arteriovenous malformation (CM-AVM) presenting during pregnancy

scientific article

Abdominal pain associated with cranial nerve palsy and peripheral neuropathy.

scientific article published on May 1997

Absence of circulating products of oxygen derived free radicals in acute severe asthma

scientific article published on 01 November 1989

Acceleration of human neutrophil apoptosis by TRAIL.

scientific article

Acute Pancreatitis Mimicking Myocardial Infarction: Potential for Inadvertent Use of Thrombolytic Therapy

scientific article published on 01 October 1993

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

scientific article published on 11 April 2016

Acute lung injury results from failure of neutrophil de-priming: a new hypothesis

scientific article published on 18 September 2012

Advances in neutrophil biology: clinical implications

scientific article published on September 2008

Agents That Elevate cAMP Inhibit Human Neutrophil Apoptosis

scientific article published on 01 December 1995

Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands

scientific article published on 22 July 2013

Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo

scientific article published on 30 December 2014

Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils

scientific article published on 13 March 2006

Author's response: co-trimoxazole treatment in idiopathic pulmonary fibrosis

scientific article published on 21 June 2013

Azithromycin therapy for neutrophilic airways disease: myth or magic?

scientific article published in March 2009

Biomarkers of eosinophilic inflammation in asthma.

scientific article published on 27 January 2014

Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium

scientific article published on 19 September 2016

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2.

scientific article published on 23 June 2017

Brief communication: identification of the authentic ancient DNA sequence in a human bone contaminated with modern DNA.

scientific article published in November 2006

Bronchoalveolar lavage in an immunosuppressed rabbit model of invasive pulmonary aspergillosis

scientific article published on 01 December 1989

C13orf31 (FAMIN) is a central regulator of immunometabolic function

scientific journal article

C5a anaphylatoxin and its role in critical illness-induced organ dysfunction

article

Cardiovascular adaptation to hypoxia and the role of peripheral resistance

scientific article published on 19 October 2017

Changes in extracellular calcium within the physiological range influence receptor-mediated inositol phosphate responses in brain and tracheal smooth muscle slices

article

Characterisation and Ca2+-dependency of the soluble and particulate Ins(1,4,5)P35-phosphatase in bovine tracheal smooth muscle

scientific article published on 01 August 1994

Characterisation of secondary metabolites associated with neutrophil apoptosis

scientific article published on 01 September 1996

Characterisation of stereospecific binding sites for inositol 1,4,5-trisphosphate in airway smooth muscle

scientific article published in February 1990

Characterization of stereospecific binding sites for [3H]-inositol (1,4,5)-trisphosphate in airway smooth muscle

scientific article published on 01 December 1989

Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils.

scientific article published in June 2004

Circulating granulocyte lifespan in compensated alcohol-related cirrhosis: a pilot study

scientific article published on September 2016

Clinical and physiological aspects of pulmonary arteriovenous malformations

scientific article published on March 1, 1988

Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung

scientific article published on 24 June 2015

Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

scientific article published on 16 June 2008

Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation.

scientific article published on 19 October 2009

Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood.

scientific article published on 13 January 2018

Detection of sustained mass increases in inositol 1,3,4,5-tetrakisphosphate in agonist-stimulated airway smooth muscle

scientific article published on 01 April 1991

Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle

scientific article published on April 1991

Diagnosing COPD in non-smokers: splitting not lumping

scientific article published on 01 June 2010

Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of (18)F-FDG PET images.

scientific article

Dissociation between β-adrenoceptor-mediated cyclic AMP accumulation and inhibition of histarnine-stimulated phosphoinositide metabolism in airways smooth muscle

scientific article published on 01 May 1997

Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema.

scientific article

Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia

scientific article published on 23 April 2004

Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin?

scientific article published in August 2009

Eating their way out of trouble: selective uptake of apoptotic eosinophils by bronchial epithelial cells

scientific article published on 01 October 2004

Effect of priming on activation and localization of phospholipase D-1 in human neutrophils

scientific article

Effects of S-salbutamol on Human Isolated Bronchus ⬇️

scientific article published on February 1, 1998

Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance.

scientific article published on 24 January 2011

Effects of tocilizumab on neutrophil function and kinetics

scientific article

Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma.

scientific article

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

scientific article published on 09 March 2022

Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells

scientific article published in July 2007

Epidermal deletion of HIF-2α stimulates wound closure

scientific article published on 13 September 2013

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity

scientific article published on 28 March 2017

Evasion of Neutrophil Extracellular Traps by Respiratory Pathogens

scientific article published on 17 November 2016

Exposure of patients to ionising radiation during lung cancer diagnostic work-up

scientific article published on 25 April 2017

Fat embolism syndrome with Purtscher's retinopathy

scientific article published in January 2013

Formation of inositol polyphosphates in airway smooth muscle after muscarinic receptor stimulation

scientific article published on 01 February 1990

Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival

scientific article

Future treatment in patients with chronic obstructive pulmonary disease: to reverse or not to reverse steroid resistance-that is the question

scientific article

Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

scientific article published on 15 October 2006

Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome

scientific article published in February 2015

Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils

scientific article

HIF isoforms in the skin differentially regulate systemic arterial pressure

scientific article published on 07 October 2013

HIF2α-arginase axis is essential for the development of pulmonary hypertension.

scientific article published on 18 July 2016

How receptors work: mechanisms of signal transduction.

scientific article

Human Cytomegalovirus Delays Neutrophil Apoptosis and Stimulates the Release of a Prosurvival Secretome

scientific article published on 25 September 2017

Hypoxia causes IL-8 secretion, Charcot Leyden crystal formation, and suppression of corticosteroid-induced apoptosis in human eosinophils.

scientific article published on 21 December 2016

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism

scientific article published on February 2017

Hypoxia prolongs neutrophil survival in vitro

scientific article published on 01 September 1995

Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils.

scientific article

Hypoxia upregulates neutrophil degranulation and potential for tissue injury

scientific article

Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

scientific article

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

scientific article

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

scientific article published on 21 April 2009

Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.

scientific article

Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus

scientific article

Idiopathic pulmonary fibrosis in a Christmas Island nuclear test veteran ⬇️

scientific article published on November 23, 2010

Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit

scientific article published on 22 August 2016

Induction of human neutrophil apoptosis by nitric oxide donors: evidence for a caspase-dependent, cyclic-GMP-independent, mechanism

scientific article published on 01 February 2000

Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells.

scientific article

Inositol phosphates and airway smooth muscle.

scientific article published on January 1989

Interleukin-10 does not directly affect the constitutive rate of human neutrophil or eosinophil apoptosis

scientific article published on 01 May 1997

Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils

scientific article published on 30 August 2010

Interstitial pneumonitis and anti-tumor necrosis factor-alpha therapy

scientific article published on 01 January 2007

Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis

scientific article published in October 2002

Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages.

scientific article published on July 1999

Kinetics of pulmonary neutrophil recruitment and clearance in a natural and spontaneously resolving model of airway inflammation.

scientific article

Lack of effect of recombinant platelet-derived growth factor on human neutrophil function.

scientific article published on April 1995

Lack of effect of zaprinast on methacholine-induced contraction and inositol 1,4,5-trisphosphate accumulation in bovine tracheal smooth muscle ⬇️

scientific article published on May 1, 1991

Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT

scientific article published on 04 September 2020

Live and let die: is neutrophil apoptosis defective in severe asthma?

scientific article published on 01 August 2010

Mathematical modeling supports the presence of neutrophil depriming in vivo

scientific article published on 20 March 2014

Measurement of Eosinophil Kinetics in Healthy Volunteers

scientific article published on 01 January 2014

Measuring whole-body neutrophil redistribution using a dedicated whole-body counter and ultra-low doses of 111Indium

scientific article published on 8 October 2010

Mechanical deformation induces depolarization of neutrophils

scientific article

Mechanics meets medicine

scientific article published in November 2013

Mechanism of accumulation of 99mTc-sulesomab in inflammation

scientific article published on 01 January 2003

Mechanotransduction in neutrophil activation and deactivation

scientific article published on 23 July 2015

Medical training in the UK: sleepwalking to disaster

scientific article

Miliary tuberculosis in edinburgh—A comparison between 1984–1992 and 1954–1967

scientific article published on 01 September 1994

Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes

scientific article published in The Lancet

NBEAL2 is required for neutrophil and NK cell function and pathogen defense

scientific article published on 7 August 2017

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosisin Vitro

scientific article published in Journal of Biological Chemistry

Neutrophil kinetics in health and disease.

scientific article

Neutrophil priming: pathophysiological consequences and underlying mechanisms.

scientific article

Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma

scientific article

Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis

scientific article published on 29 June 2006

Non-infectious pulmonary complications of newer biological agents for rheumatic diseases--a systematic literature review

scientific article

Non-infectious pulmonary toxicity of rituximab: a systematic review

scientific article

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury.

scientific article published on 29 January 2018

Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets.

scientific article

Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.

scientific article published on July 1999

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.

scientific article published on October 2001

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

scientific article

Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells ⬇️

scientific article published on June 8, 2000

Phosphoinositide metabolism in airway smooth muscle.

scientific article published on April 1994

Physiologic granulocyte destruction in vivo by apoptosis.

scientific article published in March 2004

Platelet-Derived Growth Factor-BB and Thrombin Activate Phosphoinositide 3-Kinase and Protein Kinase B: Role in Mediating Airway Smooth Muscle Proliferation

scientific article published on 01 December 1998

Pleural disease--diagnosis and management.

scientific article

Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema

scientific article

Postprandial Glycaemic Effects of a Long-Acting Somatostatin Analogue (Octreotide) in Non-Insulin Dependent Diabetes Mellitus

scientific article published on 01 March 1988

Priming and de-priming of neutrophil responses in vitro and in vivo

article

Priming differentially regulates neutrophil adhesion molecule expression/function

scientific article published on 01 September 1996

Priming induces functional coupling of N -formyl-methionyl-leucyl-phenylalanine receptors in equine neutrophils

article

Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation.

scientific article

Prolonged survival of neutrophils from patients with F508 CFTR mutations

scientific article published on 01 July 2008

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

scientific article published on 14 August 2017

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

scientific article published on 7 February 2011

Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts

scientific article published in February 2002

Pulmonary Thromboemboli Modifying the Natural History of Pulmonary Arteriovenous Malformations

scientific article published on 01 March 2011

Pulmonary complications of infliximab therapy in patients with rheumatoid arthritis

scientific article published on 01 March 2006

Pulmonary elimination rate of inhaled 99mTc-sestamibi radioaerosol is delayed in healthy cigarette smokers

scientific article published on 12 February 2008

Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome

scientific article

Quantification of Lung PET Images: Challenges and Opportunities

scientific article published on 12 January 2017

Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease

scientific article published on 29 October 2004

Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease

scientific article published on 10 February 2011

Quantification of right to left shunt at rest and during exercise in patients with pulmonary arteriovenous malformations ⬇️

scientific article published on October 1, 1992

Quantification of right to left shunt through pulmonary arteriovenous malformations using 99Tcm albumin microspheres

scientific article published on 01 November 1988

Rapid desensitization of GnRH-stimulated intracellular signalling events in alpha T3-1 and HEK-293 cells expressing the GnRH receptor ⬇️

scientific article published on November 1, 1995

Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming

article

Regulation of granulocyte apoptosis and implications for anti-inflammatory therapy ⬇️

scientific article published on July 1, 1998

Regulation of macrophage phagocytosis of apoptotic cells by cAMP

scientific article published on 01 April 1998

Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro

scientific article published on 01 October 1997

Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents

scientific article published on September 2002

RhoG regulates the neutrophil NADPH oxidase

scientific article (publication date: May 2006)

Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival

scientific article published in October 2002

Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis

scientific article

Role of neutrophil apoptosis in the resolution of pulmonary inflammation.

scientific article

Sarcoid-like granulomatous disease following etanercept treatment for RA

scientific article published on 01 March 2007

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

scientific article

Severe Colitis Associated with Pirfenidone Use in Idiopathic Pulmonary Fibrosis

scientific article published on 01 August 2016

Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents

scientific article (publication date: December 2002)

Spontaneous rupture of an intercostal artery aneurysm during air flight.

scientific article published in March 2008

TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils

scientific article

The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion

scientific article

The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary fibrosis with the Addition of Co-trimoxazole (EME-TIPAC): study protocol for a randomised controlled trial.

scientific article

The HIF/VHL pathway: from oxygen sensing to innate immunity

scientific article published on 11 October 2007

The blood supply of the islets of Langerhans in the Mongolian gerbil.

scientific article

The function and fate of neutrophils at the inflamed site: prospects for therapeutic intervention

scientific article published on 01 January 2000

The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway.

scientific article

The role of HIF-1alpha in myeloid cell inflammation

scientific article

The serpinopathies studying serpin polymerization in vivo

scientific article

The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa B-dependent IL-8 release

scientific article

Thrombin induces DNA synthesis and phosphoinositide hydrolysis in airway smooth muscle by activation of distinct receptors

scientific article published in September 2005

Time to extend ‘the timetable of tuberculosis’?

scientific article published on 01 August 1994

Transforming Growth Factor-β increases the inhibitory effects of GM-CSF and dexamethasone on neutrophil apoptosis

scientific article published on 01 May 1997

Treating idiopathic pulmonary fibrosis with the addition of co-trimoxazole: a randomised controlled trial

scientific article published on 10 November 2012

Treating idiopathic pulmonary fibrosis with the addition of co-trimoxazole: an economic evaluation alongside a randomised controlled trial

scientific article published in January 2014

Use of 111-Indium-labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects

scientific article

Use of 18FDG-pet to discriminate between infection and rejection in lung transplant recipients

scientific article

Use of technetium-99m-labeled eosinophils to detect active eosinophilic inflammation in humans.

scientific article published on October 2013

Viscoelastic properties of differentiating blood cells are fate- and function-dependent

scientific article published in 2012

What can we learn from highly purified neutrophils?

scientific article published on June 2004

Wortmannin enhances tumour necrosis factorα-stimulated neutrophil apoptosis

scientific article published on 01 February 1996

Zero G in a patient with advanced amyotrophic lateral sclerosis

scientific article published in The Lancet

[3H]inositol polyphosphate metabolism in muscarinic cholinoceptor-stimulated airways smooth muscle: accumulation of [3H]inositol 4,5 bisphosphate via a lithium-sensitive inositol polyphosphate 1-phosphatase

scientific article published on 01 February 1997

z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species

scientific article published on 30 November 2004

β-adrenoceptor induced inhibition of muscarinic receptor-stimulated phosphoinositide metabolism is agonist specific in bovine tracheal smooth muscle

scientific article published on 01 July 1991

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