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List of works by Stephen H Gillespie

A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses

scientific article

A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens

scientific article published on 24 November 2017

A dose-ranging trial to optimize the dose of rifampin in the treatment of tuberculosis

scientific article published on May 2015

A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP)

scientific article

A practical guide to measuring mutation rates in antibiotic resistance

scientific article

A spatially heterogeneous network-based metapopulation software model applied to the simulation of a pulmonary tuberculosis infection

scientific article published on 23 August 2018

An improved method for detection of pyrazinamide resistance in Mycobacterium tuberculosis

scientific article published on 02 March 2012

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution?

scientific article

Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment

scientific article published on July 2013

Biomarkers of treatment response in clinical trials of novel antituberculosis agents

scientific article published on July 2007

Blood culture bottle culture of pleural fluid in pleural infection

scientific article published on 01 April 2011

Can phenotypic data complement our understanding of antimycobacterial effects for drug combinations?

scientific article published on 01 December 2019

Centrifugation and decontamination procedures selectively impair recovery of important populations in Mycobacterium smegmatis

scientific article published on 01 August 2018

Chasing Koch's chimera.

scientific article published on April 2013

Community-acquired pneumonia and tuberculosis: differential diagnosis and the use of fluoroquinolones

scientific article published on 26 October 2013

Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis.

scientific article published in April 2018

Defining dormancy in mycobacterial disease.

scientific article

Detecting Phenotypically Resistant Mycobacterium tuberculosis Using Wavelength Modulated Raman Spectroscopy

scientific article published in January 2018

Detection and identification of bacteria in clinical samples by 16S rRNA gene sequencing: comparison of two different approaches in clinical practice

scientific article published on 8 December 2011

Direct comparison of Xpert MTB/RIF assay with liquid and solid mycobacterial culture for quantification of early bactericidal activity

scientific article published on 17 April 2013

Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients

scientific article published on 27 January 2015

Effect of cotrimoxazole on causes of death, hospital admissions and antibiotic use in HIV-infected children.

scientific article published in January 2007

Effective anti-tuberculosis therapy correlates with plasma small RNA.

scientific article published on 5 March 2015

Enhanced Methodologies for Detecting Phenotypic Resistance in Mycobacteria.

scientific article published in January 2018

Erratum to: Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials.

scientific article published on 23 February 2016

Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin.

scientific article

Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis

scientific article

Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study

scientific article published on 17 October 2018

Genomic Investigations unmask Mycoplasma amphoriforme, a new respiratory pathogen

scientific article

Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations

scientific article published on 01 August 2018

Heat-inactivation renders sputum safe and preserves RNA for downstream molecular tests

scientific article published on 28 March 2019

High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial

scientific article published on 26 October 2016

HspX knock-out in Mycobacterium tuberculosis leads to shorter antibiotic treatment and lower relapse rate in a mouse model--a potential novel therapeutic target

scientific article published on 20 November 2014

Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH

scientific article

IkappaB genetic polymorphisms and invasive pneumococcal disease

scientific article

Impact of cotrimoxazole on carriage and antibiotic resistance of Streptococcus pneumoniae and Haemophilus influenzae in HIV-infected children in Zambia

scientific article

Improved power for TB Phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods.

scientific article published on 16 May 2017

Innovative Trial Designs Are Practical Solutions for Improving the Treatment of Tuberculosis

scientific article published on 22 March 2012

Label-free optical vibrational spectroscopy to detect the metabolic state of M. tuberculosis cells at the site of disease.

scientific article

Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials

scientific article published on 4 February 2016

Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study

scientific article published on 28 March 2018

Managing malaria in tuberculosis patients on fluoroquinolone-containing regimens: assessing the risk of QT prolongation.

scientific article published on February 2012

Mimicking in-vivo exposures to drug combinations in-vitro: anti-tuberculosis drugs in lung lesions and the hollow fiber model of infection

scientific article published on 13 September 2019

Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture

scientific article published on 23 September 2019

Modelling the effects of bacterial cell state and spatial location on tuberculosis treatment: Insights from a hybrid multiscale cellular automaton model.

scientific article published on 7 March 2018

Molecular Bacterial Load Assay Concurs with Culture on NaOH-Induced Loss of Mycobacterium tuberculosis Viability

scientific article published on 25 June 2019

Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment

scientific article published on 7 September 2011

Moxifloxacin for tuberculosis

scientific article published in March 2012

Moxifloxacin replacement in contemporary tuberculosis drug regimens is ineffective against persistent Mycobacterium tuberculosis: Novel insights from the Cornell mouse model.

scientific article published on 16 April 2018

Mycobacterial Load Assay.

scientific article

New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

scientific article published on April 2014

OMNIgene.SPUTUM suppresses contaminants while maintaining Mycobacterium tuberculosis viability and obviates cold-chain transport.

scientific article

Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings

scientific article published on August 2016

PTPN22 and invasive bacterial disease

article

Pharmacokinetics, Tolerability, and Bacteriological Response of Rifampin Administered at 600, 900, and 1,200 Milligrams Daily in Patients with Pulmonary Tuberculosis.

scientific article published on 21 August 2017

Phenotypic resistance in mycobacteria: is it because I am old or fat that I resist you?

scientific article published on 9 July 2015

Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.

scientific article

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

scientific article

Pseudomonas aeruginosa intensive care unit outbreak: winnowing of transmissions with molecular and genomic typing

scientific article published on 8 December 2017

Routine use of microbial whole genome sequencing in diagnostic and public health microbiology

scientific article (publication date: 2012)

Sequetyping: serotyping Streptococcus pneumoniae by a single PCR sequencing strategy

scientific article

Shorter moxifloxacin-based regimens for drug-sensitive tuberculosis

scientific article published on 01 February 2015

Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis.

scientific article

Strategies and Challenges Involved in the Discovery of New Chemical Entities During Early-Stage Tuberculosis Drug Discovery

scientific article published on 22 March 2012

Streptococcus pseudopneumoniae identification by pherotype: a method to assist understanding of a potentially emerging or overlooked pathogen

scientific article

The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis.

scientific article published in June 2018

The adaptive potential during nasopharyngeal colonisation of Streptococcus pneumoniae ⬇️

scientific article published on September 10, 2011

The implications of model-informed drug discovery and development for tuberculosis

scientific article

The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations

scientific article

The role of moxifloxacin in tuberculosis therapy

scientific article

Tools for detection of Mycoplasma amphoriforme: a primary respiratory pathogen?

scientific article

Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status

scientific article published on 14 August 2019

Using RT qPCR for Quantifying Mycobacteria marinum from In Vitro and In Vivo Samples

scientific article published in January 2018

When is an outbreak not an outbreak? Fit, divergent strains of Mycobacterium tuberculosis display independent evolution of drug resistance in a large London outbreak.

scientific article published on 5 November 2012

Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study

scientific article

Why Do We Use 600 mg of Rifampicin in Tuberculosis Treatment?

scientific article published on May 2011

XDR-TB, what is it; how is it treated; and why is therapeutic failure so high?

scientific article published on May 2011

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