Search filters

List of works by Sina A Gharib

A macrophage sterol-responsive network linked to atherogenesis

scientific article

A pathway-based analysis on the effects of obstructive sleep apnea in modulating visceral fat transcriptome.

scientific article

A systematic analysis of protein-altering exonic variants in chronic obstructive pulmonary disease

ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study

scientific article

Acute cellular rejection elicits distinct microRNA signatures in airway epithelium of lung transplant patients.

scientific article

Admixture mapping identifies novel loci for obstructive sleep apnea in hispanic/latino americans

scientific article published on 01 February 2019

Alveolar Macrophage Transcriptional Programs Are Associated with Outcomes in Acute Respiratory Distress Syndrome

scientific article published on 01 September 2019

Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study

scientific article published in July 2015

Association of genetic loci with sleep apnea in European Americans and African-Americans: the Candidate Gene Association Resource (CARe).

scientific article

Association of sleep characteristics with atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis

scientific article

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep

scientific article published on 16 April 2019

Bridging the gap: merging clinical and inflammatory phenotypes with epithelial gene expression profiles in asthma

scientific article published on 01 December 2014

COPD disease severity and innate immune response to pathogen-associated molecular patterns

scientific article published on 4 March 2016

CYP2J2 expression in adult ventricular myocytes protects against external and drug induced ROS toxicity

scientific article published on 17 January 2018

Cell type-specific immune dysregulation in severely ill COVID-19 patients

scientific article published on 24 July 2020

Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice

scientific article published on 02 September 2019

Cellular Mechanisms of Tissue Fibrosis. 3. Novel mechanisms of kidney fibrosis ⬇️

scientific article published on January 16, 2013

Charting the transcriptional landscape of cells of renin lineage following podocyte depletion

scientific article published on 12 December 2017

Cholesterol accumulation regulates expression of macrophage proteins implicated in proteolysis and complement activation

scientific article

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

scientific article

Common variants in DRD2 are associated with sleep duration: the CARe consortium

scientific article

Comparative evaluation of miRNA expression between in vitro and in vivo airway epithelium demonstrates widespread differences.

scientific article published on 31 August 2013

Comparison of statistical data models for identifying differentially expressed genes using a generalized likelihood ratio test.

scientific article

Computational identification of key biological modules and transcription factors in acute lung injury.

scientific article published on 30 December 2005

Cytometry TOF identifies alveolar macrophage subtypes in acute respiratory distress syndrome.

scientific article

Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury

scientific article published in Scientific Reports

Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo

scientific article

Epigenetic Signatures of Cigarette Smoking

scientific article

Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations

scientific article published on 01 August 2019

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.

scientific article

Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction

scientific article published on 11 May 2015

Exploration of the normal human bronchoalveolar lavage fluid proteome ⬇️

scientific article published on April 1, 2008

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

scientific article published on 25 February 2019

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

scientific article

Genetic variability of smoking persistence in African Americans

scientific article

Genetic variants in RBFOX3 are associated with sleep latency

scientific article

Genome-wide association analysis identifies six new loci associated with forced vital capacity

scientific article

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

scientific article

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction

scientific article

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

scientific article

Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants

scientific article

Heterogeneity of epigenetic changes at ischemia/reperfusion- and endotoxin-induced acute kidney injury genes.

scientific article

Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.

scientific article published on 11 February 2016

Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.

scientific article

Induced sputum proteome in healthy subjects and asthmatic patients

scientific article

Integrative miRNA-mRNA profiling of adipose tissue unravels transcriptional circuits induced by sleep fragmentation

scientific article

Integrative pathway genomics of lung function and airflow obstruction

scientific article

Interleukin-17A Is Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome

scientific article published on 4 November 2015

Intermittent hypoxia activates temporally coordinated transcriptional programs in visceral adipose tissue

scientific article published on 16 November 2011

Intermittent hypoxia mobilizes bone marrow-derived very small embryonic-like stem cells and activates developmental transcriptional programs in mice

scientific article published in November 2010

Large Meta-Analysis in the CHARGE Consortium Provides Evidence For an Association of Serum Vitamin D With Pulmonary Function

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function ⬇️

scientific article

Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung

scientific article (publication date: February 2017)

Lung Pericytes and Resident Fibroblasts: Busy Multitaskers.

scientific article

Mapping the lung proteome in cystic fibrosis.

scientific article published on June 2009

Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis.

scientific article

Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells

scientific article published on 20 December 2012

Matrix metalloproteinases in emphysema.

scientific article published on 30 January 2018

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

scientific article

Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function

scientific article published on 12 September 2018

Meta-analysis of exome array data identifies six novel genetic loci for lung function

scientific article published on 12 January 2018

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Molecular mechanisms underlying variations in lung function: a systems genetics analysis

scientific article published on 21 September 2015

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

scientific article published on 12 November 2019

Multi-ethnic Meta-analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea Related Quantitative Trait Locus in Men.

scientific article

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

scientific article published on 22 December 2017

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

scientific article published in Nature Communications

Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung

scientific article published on 10 March 2009

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

scientific article published on 2 December 2014

Obstructive sleep apnea and cpap therapy alter distinct transcriptional programs in subcutaneous fat tissue

scientific article published on 24 December 2019

Of mice and men: comparative proteomics of bronchoalveolar fluid.

scientific article

Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association

scientific article published on 01 March 2019

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

scientific article published in Nature Communications

Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.

scientific article

Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease.

scientific article published on 8 December 2016

Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.

scientific article published in March 2012

Peripheral and Alveolar Cell Transcriptional Programs are Distinct in Acute Respiratory Distress Syndrome.

scientific article published on 14 July 2017

Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring children with normal polysomnographic findings.

scientific article

Plasticity of airway epithelial cell transcriptome in response to flagellin

scientific article

Prediction of mechanical properties of human atherosclerotic tissue by high-frequency intravascular ultrasound imaging. An in vitro study ⬇️

scientific article published on January 1, 1992

Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome

scientific article

Proteomic landscape of bronchoalveolar lavage fluid in human immunodeficiency virus infection

scientific article published on 8 November 2013

Proteomic profiling of bronchoalveolar lavage fluid in critically ill patients with ventilator-associated pneumonia

scientific article

Reply to Walter and Reyfman: Transcriptomic Analysis of Alveolar Immune Cells in Acute Respiratory Distress Syndrome: To Lump or to Split?

scientific article published on 01 November 2019

Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis.

scientific article published on October 2013

SYSTEM-WIDE MAPPING OF ACTIVATED CIRCUITRY IN EXPERIMENTAL SYSTEMIC INFLAMMATORY RESPONSE SYNDROME.

scientific article

Sample processing and single cell RNA-sequencing of peripheral blood immune cells from COVID-19 patients

scientific article published on 12 May 2021

Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells.

scientific article published on 26 July 2016

Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level

scientific article published on 24 October 2019

Sex differences in transcriptomic profiles in aged kidney cells of renin lineage

scientific article published on 18 April 2018

Shotgun MS proteomic analysis of bronchoalveolar lavage fluid in normal subjects

scientific article

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

scientific article

Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes

scientific article

Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.

scientific article published on 17 June 2016

Symptom profiles and inflammatory markers in moderate to severe COPD.

scientific article published on 03 December 2016

Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes

scientific article published on 17 January 2018

Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles

scientific article published on 08 August 2019

Synthesis and characterization of a new fluorescent probe for measuring potassium.

scientific article published in February 1990

Systematic identification of trans eQTLs as putative drivers of known disease associations

scientific article (publication date: October 2013)

TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury.

scientific article published on 03 July 2013

The Effects of Genotype × Phenotype Interactions on Transcriptional Response to Silver Nanoparticle Toxicity in Organotypic Cultures of Murine Tracheal Epithelial Cells

scientific article published on 01 January 2020

The transcriptional landscape of age in human peripheral blood

scientific article

Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.

scientific article

Transcriptional Signatures of Sleep Duration Discordance in Monozygotic Twins

scientific article published on January 2017

Transcriptional Survey of Alveolar Macrophages in a Murine Model of Chronic Granulomatous Inflammation Reveals Common Themes with Human Sarcoidosis.

scientific article published on 6 December 2017

Transcriptional and functional diversity of human macrophage repolarization

scientific article published on 14 November 2018

Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxia

scientific article published on 10 May 2011

Transcriptional landscape of glomerular parietal epithelial cells

scientific article

Transcriptional signatures in donor lungs from donation after cardiac death vs after brain death: a functional pathway analysis.

scientific article published on 18 November 2010

Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea

scientific article

Treatment of obstructive sleep apnea alters cancer-associated transcriptional signatures in circulating leukocytes.

scientific article published on April 2014

Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants

scientific article published on 14 October 2020

Widespread activation of immunity and pro-inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange

scientific article published on April 2016

miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways.

scientific article published on 08 December 2016

Paulina is supported by:

About Paulina

Help