List of works - Sina A Gharib

Systematic identification of trans eQTLs as putative drivers of known disease associations

scientific article (publication date: October 2013)

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

scientific article

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

scientific article

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

scientific article

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

scientific article

Epigenetic Signatures of Cigarette Smoking

scientific article

The transcriptional landscape of age in human peripheral blood

scientific article

Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis.

scientific article published on October 2013

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction

scientific article

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

scientific article

Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.

scientific article published in March 2012

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

scientific article

Cellular Mechanisms of Tissue Fibrosis. 3. Novel mechanisms of kidney fibrosis

scientific article published on January 16, 2013

Genome-wide association analysis identifies six new loci associated with forced vital capacity

scientific article

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

scientific article published on 22 December 2017

Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.

scientific article

MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis

scientific article published on August 20, 2013

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

scientific article published on 2 December 2014

A macrophage sterol-responsive network linked to atherogenesis

scientific article

Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.

scientific article

Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome

scientific article

Computational identification of key biological modules and transcription factors in acute lung injury.

scientific article published on 30 December 2005

Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants

scientific article

Association of sleep characteristics with atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis

scientific article

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function

scientific article

TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury.

scientific article published on 03 July 2013

Of mice and men: comparative proteomics of bronchoalveolar fluid.

scientific article

Exploration of the normal human bronchoalveolar lavage fluid proteome

scientific article published on April 1, 2008

Integrative miRNA-mRNA profiling of adipose tissue unravels transcriptional circuits induced by sleep fragmentation

scientific article

Mapping the lung proteome in cystic fibrosis.

scientific article published on June 2009

Association of genetic loci with sleep apnea in European Americans and African-Americans: the Candidate Gene Association Resource (CARe).

scientific article

Intermittent hypoxia mobilizes bone marrow-derived very small embryonic-like stem cells and activates developmental transcriptional programs in mice

scientific article published in November 2010

Molecular mechanisms underlying variations in lung function: a systems genetics analysis

scientific article published on 21 September 2015

Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.

scientific article published on 11 February 2016

Lung Pericytes and Resident Fibroblasts: Busy Multitaskers.

scientific article

Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung

scientific article published on 10 March 2009

Intermittent hypoxia activates temporally coordinated transcriptional programs in visceral adipose tissue

scientific article published on 16 November 2011

Induced sputum proteome in healthy subjects and asthmatic patients

scientific article

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

scientific article published on 25 February 2019

Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.

scientific article

Proteomic profiling of bronchoalveolar lavage fluid in critically ill patients with ventilator-associated pneumonia

scientific article

Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea

scientific article

Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung

scientific article (publication date: February 2017)

Common variants in DRD2 are associated with sleep duration: the CARe consortium

scientific article

Heterogeneity of epigenetic changes at ischemia/reperfusion- and endotoxin-induced acute kidney injury genes.

scientific article

Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction

scientific article published on 11 May 2015

Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells

scientific article published on 20 December 2012

Integrative pathway genomics of lung function and airflow obstruction

scientific article

Treatment of obstructive sleep apnea alters cancer-associated transcriptional signatures in circulating leukocytes.

scientific article published on April 2014

Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring children with normal polysomnographic findings.

scientific article

List of works by Sina A Gharib

Systematic identification of trans eQTLs as putative drivers of known disease associations

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Epigenetic Signatures of Cigarette Smoking

The transcriptional landscape of age in human peripheral blood

Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis.

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

Cellular Mechanisms of Tissue Fibrosis. 3. Novel mechanisms of kidney fibrosis

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.

MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

A macrophage sterol-responsive network linked to atherogenesis

Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.

Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome

Computational identification of key biological modules and transcription factors in acute lung injury.

Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants

Association of sleep characteristics with atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function

TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury.

Of mice and men: comparative proteomics of bronchoalveolar fluid.

Exploration of the normal human bronchoalveolar lavage fluid proteome

Integrative miRNA-mRNA profiling of adipose tissue unravels transcriptional circuits induced by sleep fragmentation

Mapping the lung proteome in cystic fibrosis.

Association of genetic loci with sleep apnea in European Americans and African-Americans: the Candidate Gene Association Resource (CARe).

Intermittent hypoxia mobilizes bone marrow-derived very small embryonic-like stem cells and activates developmental transcriptional programs in mice

Molecular mechanisms underlying variations in lung function: a systems genetics analysis

Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.

Lung Pericytes and Resident Fibroblasts: Busy Multitaskers.

Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung

Intermittent hypoxia activates temporally coordinated transcriptional programs in visceral adipose tissue

Induced sputum proteome in healthy subjects and asthmatic patients

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.

Proteomic profiling of bronchoalveolar lavage fluid in critically ill patients with ventilator-associated pneumonia

Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea

Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung

Common variants in DRD2 are associated with sleep duration: the CARe consortium

Heterogeneity of epigenetic changes at ischemia/reperfusion- and endotoxin-induced acute kidney injury genes.

Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction

Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells

Integrative pathway genomics of lung function and airflow obstruction

Treatment of obstructive sleep apnea alters cancer-associated transcriptional signatures in circulating leukocytes.

Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring children with normal polysomnographic findings.