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List of works by David S Roos

A Lipolytic Lecithin:Cholesterol Acyltransferase Secreted by Toxoplasma Facilitates Parasite Replication and Egress

scientific article published on 22 December 2015

A large-scale proteogenomics study of apicomplexan pathogens-Toxoplasma gondii and Neospora caninum

scientific article published on 15 May 2015

A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondii

scientific article published on 8 November 2011

A novel GDP-dependent pyruvate kinase isozyme from Toxoplasma gondii localizes to both the apicoplast and the mitochondrion

scientific article published on 6 March 2008

A novel multifunctional oligonucleotide microarray for Toxoplasma gondii

scientific article

A novel polymer of tubulin forms the conoid of Toxoplasma gondii

scientific article

A plastid of probable green algal origin in Apicomplexan parasites.

scientific article

A plastid organelle as a drug target in apicomplexan parasites.

scientific article published in November 1997

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

scientific article

A survey of the Leishmania major Friedlin strain V1 genome by shotgun sequencing: a resource for DNA microarrays and expression profiling

article

A systems biological view of intracellular pathogens

scientific article

Acidic compartments and rhoptry formation in Toxoplasma gondii.

scientific article

Amino-terminal control of transgenic protein expression levels in Toxoplasma gondii

scientific article published in April 2002

AmoebaDB and MicrosporidiaDB: functional genomic resources for Amoebozoa and Microsporidia species

scientific article

An insertional trap for conditional gene expression in Toxoplasma gondii: identification of TAF250 as an essential gene

scientific article published on 28 October 2010

ApiDB: integrated resources for the apicomplexan bioinformatics resource center

scientific article

ApiEST-DB: analyzing clustered EST data of the apicomplexan parasites

scientific article

Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells

scientific article

Assessing performance of orthology detection strategies applied to eukaryotic genomes

scientific article published on 18 April 2007

Bystander chronic infection negatively impacts development of CD8(+) T cell memory.

scientific article published on May 2014

Characterization of Extreme Apical Antigens from Toxoplasma gondii

scientific article published on 01 November 1994

Chemical genetics of Plasmodium falciparum

scientific article (publication date: 20 May 2010)

Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

scientific article

ClinEpiDB: an open-access clinical epidemiology database resource encouraging online exploration of complex studies

scientific article published on 25 November 2019

ClinEpiDB: an open-access clinical epidemiology database resource encouraging online exploration of complex studies

scientific article published in 2020

Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii

scientific article

Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy

scientific article published in 2012

Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control

scientific article

Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii

scientific article

Constitutive Calcium-independent Release of Toxoplasma gondii Dense Granules Occurs through the NSF/SNAP/SNARE/Rab Machinery

scientific article published in Journal of Biological Chemistry

Creating a honey bee consensus gene set

scientific article published on January 2007

Cryptic organelle homology in apicomplexan parasites: insights from evolutionary cell biology.

scientific article published on 8 August 2013

Crystal Structure of Toxoplasma gondii Porphobilinogen Synthase

scientific article

Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding 1 1Edited by I. A. Wilson

scientific article published on 01 February 2000

Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.

scientific article

Curation of the Plasmodium falciparum genome

scientific article

Cysteine and serine protease inhibitors block intracellular development and disrupt the secretory pathway of Toxoplasma gondii

scientific article published in February 2002

Cytoskeletal components of an invasion machine--the apical complex of Toxoplasma gondii ⬇️

scientific article

Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis

scientific article

Daughter cell assembly in the protozoan parasite Toxoplasma gondii

scientific article

Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii.

scientific article published in July 2001

Differential induction of TLR3-dependent innate immune signaling by closely related parasite species

scientific article

Differential localization of alternatively spliced hypoxanthine-xanthine-guanine phosphoribosyltransferase isoforms in Toxoplasma gondii

scientific article

Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

scientific article published in January 2003

Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii

scientific article

Dynamics of Toxoplasma gondii differentiation

scientific article

Dynamics of the Toxoplasma gondii inner membrane complex.

scientific article

EuPathDB: The Eukaryotic Pathogen Genomics Database Resource.

scientific article

EuPathDB: a portal to eukaryotic pathogen databases

scientific article

EuPathDB: the eukaryotic pathogen database

scientific article

EuPathDB: the eukaryotic pathogen genomics database resource

scientific article

Evigan: a hidden variable model for integrating gene evidence for eukaryotic gene prediction

scientific article published on 10 January 2008

Evolutionary cell biology: two origins, one objective

scientific article

Evolutionary constraints on structural similarity in orthologs and paralogs

scientific article published on June 2009

Expression, selection, and organellar targeting of the green fluorescent protein in Toxoplasma gondii.

scientific article published in May 1998

Fitness effects of DHFR-TS mutations associated with pyrimethamine resistance in apicomplexan parasites

scientific article published on November 2003

Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways

scientific article (publication date: 4 May 2011)

Function of Cytoplasmic Fibers in Syncytia

scientific article published on 01 January 1982

Functional Inactivation of Immature Dendritic Cells by the Intracellular Parasite Toxoplasma gondii

scientific article published on 01 August 2004

Functional characterization of a novel Toxoplasma gondii glycosyltransferase: UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3.

scientific article

FungiDB: An Integrated Bioinformatic Resource for Fungi and Oomycetes.

scientific article published on 20 March 2018

FungiDB: an integrated functional genomics database for fungi

scientific article published on 7 November 2011

Gene Discovery by EST Sequencing in Toxoplasma gondii Reveals Sequences Restricted to the Apicomplexa ⬇️

scientific article published on January 1, 1998

Gene discovery in the apicomplexa as revealed by EST sequencing and assembly of a comparative gene database

scientific article

Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit-and-run mutagenesis

article

Genetics. Themes and variations in apicomplexan parasite biology

scientific article

Genome sequence of the human malaria parasite Plasmodium falciparum

scientific article

Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology

scientific article

Genomic scale analysis of lateral gene transfer in Apicomplexan parasites: insights into early eukaryotic evolution, host-pathogen interaction and drug target development.

scientific article published on 20 November 2007

Genomic-scale prioritization of drug targets: the TDR Targets database

scientific article

GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis

scientific article

Golgi and centrosome cycles in Toxoplasma gondii

scientific article published on 17 October 2005

Golgi biogenesis in Toxoplasma gondii

scientific article published in Nature

Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii.

scientific article published on May 1996

Homologous recombination and gene replacement at the dihydrofolate reductase-thymidylate synthase locus in Toxoplasma gondii.

scientific article published in February 1994

IL-10 is not required to prevent immune hyperactivity during memory responses to Toxoplasma gondii.

scientific article published in May 2004

Identification and characterization of differentiation mutants in the protozoan parasite Toxoplasma gondii

scientific article

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach

scientific article

Identification of surprisingly diverse type IV pili, across a broad range of gram-positive bacteria

scientific article

Identity crisis? The need for systematic gene IDs.

scientific article

In silico identification of specialized secretory-organelle proteins in apicomplexan parasites and in vivo validation in Toxoplasma gondii

scientific article

In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii

scientific article

In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase

scientific article

Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics.

scientific article

Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii.

scientific article

Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus.

scientific article

Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation.

scientific article published in June 1996

Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses

scientific article

Interleukin-10 does not contribute to the pathogenesis of a virulent strain of Toxoplasma gondii

scientific article published on 01 June 2001

Isolation and Characterization of TgVP1, a Type I Vacuolar H+-translocating Pyrophosphatase fromToxoplasma gondii

scientific article published in Journal of Biological Chemistry

Isolation of mouse cell lines resistant to the fusion-inducing effect of polyethylene glycol

scientific article published on 01 May 1980

Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii

scholarly article

Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii

scientific article published on 15 June 2009

Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes

scientific article published on 7 January 2016

Malaria vaccines: if at first you don't succeed...

scientific article

Measuring tubulin content in Toxoplasma gondii: a comparison of laser-scanning confocal and wide-field fluorescence microscopy

scientific article

Membrane alterations and other morphological features associated with polyethylene glycol-induced cell fusion

scientific article published on December 1, 1979

MicrobiomeDB: a systems biology platform for integrating, mining and analyzing microbiome experiments

scientific article

Microtubules, but not actin filaments, drive daughter cell budding and cell division in Toxoplasma gondii

scientific article

Mining the Plasmodium genome database to define organellar function: what does the apicoplast do? ⬇️

scientific article

Molecular genetic tools for the identification and analysis of drug targets in Toxoplasma gondii.

scientific article published on January 1996

Multiple functionally redundant signals mediate targeting to the apicoplast in the apicomplexan parasite Toxoplasma gondii

scientific article

N-terminal positively charged amino acids, but not their exact position, are important for apicoplast transit peptide fidelity in Toxoplasma gondii

scientific article published on 28 August 2006

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

scientific article (publication date: 13 October 1998)

Nuclear-encoded, plastid-targeted genes suggest a single common origin for apicomplexan and dinoflagellate plastids.

scientific article

O-fucosylated glycoproteins form assemblies in close proximity to the nuclear pore complexes of Toxoplasma gondii

scientific article published on 23 September 2016

Organellar dynamics during the cell cycle of Toxoplasma gondii.

scientific article published on 14 April 2008

OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups

scientific article

OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes

scientific article (publication date: September 2003)

PlasmoDB v5: new looks, new genomes

scientific article published on 6 October 2006

PlasmoDB: exploring genomics and post-genomics data of the malaria parasite, Plasmodium falciparum

scientific article

PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data

scientific article

PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished).

scientific article

Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential

scientific article

Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research

scientific article

Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells

scientific article

Primary structure of the dihydrofolate reductase-thymidylate synthase gene from Toxoplasma gondii.

scientific article published on March 1993

Protozoan genomics for drug discovery.

scientific article

Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii

scientific article

Pyruvate kinase type-II isozyme in Plasmodium falciparum localizes to the apicoplast

scientific article (publication date: March 2009)

Recombinant expression, purification, and characterization of Toxoplasma gondii adenosine kinase

article

Replication and distribution of Toxoplasma gondii in the small intestine after oral infection with tissue cysts

scientific article published on 4 March 2013

Reranking candidate gene models with cross-species comparison for improved gene prediction

scientific article

SchistoDB: an updated genome resource for the three key schistosomes of humans

scientific article

Secretory traffic in the eukaryotic parasite Toxoplasma gondii: less is more

scientific article

Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.

scientific article published on December 1993

Stage-specific expression of a selectable marker in Toxoplasma gondii permits selective inhibition of either tachyzoites or bradyzoites.

scientific article published in September 1997

Standardized metadata for human pathogen/vector genomic sequences

scientific article (publication date: 2014)

Subcellular antigen location influences T-cell activation during acute infection with Toxoplasma gondii

scientific article

Subpellicular microtubules associate with an intramembranous particle lattice in the protozoan parasite Toxoplasma gondii

scientific article published on 01 January 1997

TDR Targets: a chemogenomics resource for neglected diseases

scientific article published on 23 November 2011

Targeted disruption of Toxoplasma gondii serine protease inhibitor 1 increases bradyzoite cyst formation in vitro and parasite tissue burden in mice

scientific article published on 27 December 2011

Targeting and processing of nuclear-encoded apicoplast proteins in plastid segregation mutants of Toxoplasma gondii.

scientific article published on 23 April 2001

Targeting of soluble proteins to the rhoptries and micronemes in Toxoplasma gondii

scientific article published on 01 March 2001

The Eukaryotic Pathogen Databases: a functional genomic resource integrating data from human and veterinary parasites

scientific article

The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii

scientific article published on 21 July 2015

The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

scientific article

The Plasmodium genome database

scientific article published in Nature

The Strategies WDK: a graphical search interface and web development kit for functional genomics databases

scientific article

The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology

scientific article

The genomics of malaria infection

scientific article

The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii.

scientific article published on August 1999

The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation

scientific article published on 21 July 2008

The search for the missing link: a relic plastid in Perkinsus?

scientific article published on 22 August 2011

The transcriptome of Toxoplasma gondii

scientific article

Toward community standards in the quest for orthologs ⬇️

scientific article (publication date: 15 March 2012)

Toxicity of folic acid analogs in cultured human cells: a microtiter assay for the analysis of drug competition.

scientific article

ToxoDB: accessing the Toxoplasma gondii genome

scientific article

ToxoDB: an integrated Toxoplasma gondii database resource

scientific article

Toxoplasma GondiiBradyzoites Form Spontaneously during Sporozoite-Initiated Development ⬇️

scientific article published on October 1, 1998

Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated.

scientific article published in July 2005

Toxoplasma gondii purine nucleoside phosphorylase biochemical characterization, inhibitor profiles, and comparison with the Plasmodium falciparum ortholog

scientific article published on 7 July 2006

Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast

scientific article

Toxoplasma gondii seroprevalence in Mali.

scientific article published on 27 August 2012

Toxoplasma gondii sporozoites form a transient parasitophorous vacuole that is impermeable and contains only a subset of dense-granule proteins ⬇️

scientific article published on November 1, 1997

Toxoplasma gondii: a family of apical antigens associated with the cytoskeleton.

scientific article

Traffic jams: protein transport in Plasmodium falciparum.

scientific article

Transcript initiation, polyadenylation, and functional promoter mapping for the dihydrofolate reductase-thymidylate synthase gene of Toxoplasma gondii

scientific article published in October 2004

Transcriptome of axenic liver stages of Plasmodium yoelii

scientific article

Transport and trafficking: Toxoplasma as a model for Plasmodium.

scientific article

TriTrypDB: a functional genomic resource for the Trypanosomatidae

scientific article

Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

scientific article published in March 2004

Using OrthoMCL to assign proteins to OrthoMCL-DB groups or to cluster proteomes into new ortholog groups

scientific article

Variability and heritability of cell division pathways in Toxoplasma gondii

scientific article

Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells

scientific article

[7] Amplification of genes in somatic mammalian cells

article

cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii

scientific article published in October 2003

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