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List of works by Alexandre Prat

A novel microRNA-132-sirtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis [corrected].

scientific article

A roadmap to precision medicine for multiple sclerosis

scientific article published on 22 January 2020

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier

scientific article published in January 2016

Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

scientific article published on 23 December 2007

Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers

scientific article published on 01 November 2019

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

scientific article

Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites

scientific article published on 10 March 2021

An optimized method to process mouse CNS to simultaneously analyze neural cells and leukocytes by flow cytometry

scientific article published on 25 March 2015

An updated histological classification system for multiple sclerosis lesions

scientific article

Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis

scientific article

Anti-inflammatory disease modifying treatment and disability progression in primary progressive multiple sclerosis: a cohort study

scientific article published on 02 November 2018

Anti-inflammatory disease-modifying treatment and short-term disability progression in SPMS.

scientific article published on 9 August 2017

Antibody-Independent Function of Human B Cells Contributes to Antifungal T Cell Responses.

scientific article published on 8 March 2017

Assessing the risk of multiple sclerosis disease-modifying therapies

scientific article published on 26 June 2019

Association of Inflammation and Disability Accrual in Patients With Progressive-Onset Multiple Sclerosis

scientific article published on 01 November 2018

Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis

scientific article published on 01 January 2019

Association of Sustained Immunotherapy With Disability Outcomes in Patients With Active Secondary Progressive Multiple Sclerosis

scientific article published on 27 July 2020

Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

scientific article published on 01 September 2019

B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation

scientific article

B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients

scientific article published on 12 September 2011

B7 expression and antigen presentation by human brain endothelial cells: requirement for proinflammatory cytokines.

scientific article published on February 2000

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

scientific article

Blood-brain barrier promotes differentiation of human fetal neural precursor cells.

scientific article published in April 2009

Bradykinin B1 receptor expression and function on T lymphocytes in active multiple sclerosis

scientific article published on 01 December 1999

Brain-immune connection: immuno-regulatory properties of CNS-resident cells

scientific article

CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

scientific article published on 11 January 2019

Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis

scientific article

Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin

scientific article published on 4 November 2011

Characterization of T cell lines derived from glatiramer-acetate-treated multiple sclerosis patients

scientific article published on 01 August 2000

Cladribine versus fingolimod, natalizumab and interferon β for multiple sclerosis.

scientific article

Comparative efficacy of first-line natalizumab vs IFN-β or glatiramer acetate in relapsing MS.

scientific article published on April 2016

Comparison of fingolimod, dimethyl fumarate and teriflunomide for multiple sclerosis

scientific article published on 13 January 2019

Contribution of different relapse phenotypes to disability in multiple sclerosis.

scientific article published on 7 April 2016

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

scientific article published on 08 April 2019

Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis

scientific article

Cytotoxic NKG2C+ CD4 T cells target oligodendrocytes in multiple sclerosis.

scientific article published on 8 February 2013

Death receptor expression and function at the human blood brain barrier.

scientific article published on 28 March 2007

Defining reliable disability outcomes in multiple sclerosis

scientific article published on 10 September 2015

Defining secondary progressive multiple sclerosis

scientific article published on 7 July 2016

Delay from treatment start to full effect of immunotherapies for multiple sclerosis

scientific article published on 01 September 2020

Determinants of Human B Cell Migration Across Brain Endothelial Cells ⬇️

scientific article published on May 1, 2003

Differential effects of Th1 and Th2 lymphocyte supernatants on human microglia

scientific article published in April 2003

Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation

scientific article published on 5 March 2013

Disability outcomes of early cerebellar and brainstem symptoms in multiple sclerosis

scientific article published on 15 June 2020

Disruption of central nervous system barriers in multiple sclerosis

scientific article published on 07 July 2010

Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.

scientific article published on 09 January 2017

EGFL7 reduces CNS inflammation in mouse

scientific article published on 26 February 2018

Early clinical markers of aggressive multiple sclerosis

scientific article published on 09 May 2020

Effect of Disease Modifying Therapy on Disability in Relapsing-Remitting Multiple Sclerosis Over 15 Years

scientific article published on 28 December 2020

Endo-MitoEGFP mice: a novel transgenic mouse with fluorescently marked mitochondria in microvascular endothelial cells

scientific article

Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation

scientific article published on 17 January 2019

EphrinB1 and EphrinB2 regulate T cell chemotaxis and migration in experimental autoimmune encephalomyelitis and multiple sclerosis.

scientific article

Epstein-Barr virus-associated immune reconstitution inflammatory syndrome as possible cause of fulminant multiple sclerosis relapse after natalizumab interruption.

scientific article

Erratum: Puscas, I.; et al. IVIVC Assessment of Two Mouse Brain Endothelial Cell Models for Drug Screening. Pharmaceutics 2019, 11, 587

scientific article published on 04 June 2020

Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

scientific article published in November 2016

Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems

scientific article published on 23 March 2007

Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis.

scientific article

Firategrast: natalizumab in a pill?

scientific article published on 05 January 2012

Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions.

scientific article published in November 2014

Frailty in ageing persons with multiple sclerosis

scientific article published on 27 May 2020

Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment

scientific article published in October 2008

Functions of lipid raft membrane microdomains at the blood-brain barrier

scientific article published on 30 May 2009

Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System

scientific article published on 01 January 2020

Glial cell influence on the human blood-brain barrier

scientific article

Glial influence on the blood brain barrier.

scientific article published on 07 October 2013

Glial influences on BBB functions and molecular players in immune cell trafficking.

scientific article published on 07 October 2015

Glial regulation of the blood-brain barrier in health and disease.

scientific article published on 06 August 2015

Gut-licensed IFNγ NK cells drive LAMP1TRAIL anti-inflammatory astrocytes

scientific article

Heterogeneity of T-lymphocyte function in primary progressive multiple sclerosis: relation to magnetic resonance imaging lesion volume

Highly active immunomodulatory therapy ameliorates accumulation of disability in moderately advanced and advanced multiple sclerosis

scientific article published on 28 September 2016

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

scientific article published on 04 May 2011

How do immune cells support and shape the brain in health, disease, and aging?

scientific article

How safe is natalizumab during pregnancy?

scientific article published on 12 November 2014

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

scientific article

Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis

scientific article published on 8 November 2011

Human brain endothelial cells supply support for monocyte immunoregulatory functions

scientific article published in February 2003

Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis.

scientific article published on 19 April 2018

Humanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis

scientific article published on 9 April 2018

IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation

scientific article published on 31 May 2016

IL-1β enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells

scientific article

IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8

scientific article published on 01 January 2021

IVIVC Assessment of Two Mouse Brain Endothelial Cell Models for Drug Screening

scientific article published on 08 November 2019

Immunologic privilege in the central nervous system and the blood-brain barrier

scientific article published on 17 October 2012

Immunological and pathological characterization of fatal rebound MS activity following natalizumab withdrawal

scientific article published in April 2016

Incidence of pregnancy and disease-modifying therapy exposure trends in women with multiple sclerosis: A contemporary cohort study

scientific article published on 03 January 2019

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology

scientific article published on 18 January 2019

Inflammatory potential and migratory capacities across human brain endothelial cells of distinct glatiramer acetate-reactive T cells generated in treated multiple sclerosis patients.

scientific article published on April 2004

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation.

scientific article published in December 2015

Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis

scientific article published in April 2005

Interleukin-15 enhances proinflammatory T-cell responses in patients with MS and EAE

scientific article published on 15 December 2020

Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function

scientific article published on 11 August 2020

Interpericyte tunnelling nanotubes regulate neurovascular coupling

scientific article published on 12 August 2020

Isolation of endothelial cells, pericytes and astrocytes from mouse brain

scientific article published on 18 December 2019

Isolation of human brain endothelial cells and characterization of lipid raft-associated proteins by mass spectroscopy

scientific article published on 01 January 2011

JAML mediates monocyte and CD8 T cell migration across the brain endothelium

scientific article

Kinin B1 receptor expression and function on human brain endothelial cells

scientific article published on 01 October 2000

Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability.

scientific article published in May 2005

Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS

scientific article published in 2012

Laquinimod enhances central nervous system barrier functions.

scientific article

Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis

scientific article published on 12 April 2012

Long-term disability trajectories in primary progressive MS patients: A latent class growth analysis

scientific article published on April 2017

Lymphocyte migration and multiple sclerosis: relation with disease course and therapy

scientific article published on 01 August 1999

MAFG-driven astrocytes promote CNS inflammation

scientific article published on 12 February 2020

Managing Multiple Sclerosis: Treatment Initiation, Modification, and Sequencing

scientific article published on 12 June 2018

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system.

scientific article published on 13 September 2012

Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation.

scientific article

Meningeal Tertiary Lymphoid Tissues and Multiple Sclerosis: A Gathering Place for Diverse Types of Immune Cells during CNS Autoimmunity

scientific article

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

scientific article published on 05 December 2019

MicroRNA-223 protects neurons from degeneration in experimental autoimmune encephalomyelitis

scientific article published on 01 October 2019

MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis.

scientific article published on April 2013

Migration of multiple sclerosis lymphocytes through brain endothelium

scientific article published in March 2002

Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry

scientific article published on 01 August 2019

Myeloid cell transmigration across the CNS vasculature triggers IL-1β-driven neuroinflammation during autoimmune encephalomyelitis in mice.

scientific article

NG2 immunoreactivity on human brain endothelial cells.

scientific article

NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis.

scientific article published in January 2007

Netrin 1 regulates blood-brain barrier function and neuroinflammation

scientific article

Neuronal microRNA regulation in Experimental Autoimmune Encephalomyelitis

scientific article published in Scientific Reports

Neuropeptide K potently stimulates the hydrolysis of phosphatidylinositol in the rat spinal cord

scientific article published on 01 September 1993

Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases

scientific article (publication date: September 2014)

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner

scientific article published on 28 December 2017

One more role for the gut: microbiota and blood brain barrier

scientific article published on January 2016

Overcoming the Brain Barriers: From Immune Cells to Nanoparticles

scientific article published on 12 December 2019

Pathogenesis of multiple sclerosis.

scientific article

Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way.

scientific article

Predictors of long-term disability accrual in relapse-onset multiple sclerosis

scientific article published on 4 May 2016

Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.

scientific article published in September 2009

Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses.

scientific article published on 9 December 2015

Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy

scientific article published on October 2015

QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis

scientific article published on 01 December 2020

RNA-binding protein altered expression and mislocalization in MS

scientific article published on 26 March 2020

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

scientific article published on 03 January 2019

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

scientific article published on 01 April 2019

Regulation and Functional Effects of Monocyte Migration across Human Brain-Derived Endothelial Cells ⬇️

scientific article published on April 1, 2003

Regulation of Th1 and Th2 lymphocyte migration by human adult brain endothelial cells.

scientific article

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.

scientific article

Regulation of cellular and molecular trafficking across human brain endothelial cells by Th1- and Th2-polarized lymphocytes.

scientific article

Retinoic acid induces blood-brain barrier development.

scientific article published on January 2013

Risk of secondary progressive multiple sclerosis: A longitudinal study

scientific article published on 09 August 2019

Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions.

scientific article published in November 2011

Roles of CD4 and CD8 T Lymphocytes in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?

scientific article published on 14 March 2016

Sex-dependent factors encoded in the immune compartment dictate relapsing or progressive phenotype in demyelinating disease

scientific article published on 21 March 2019

Special issue on molecular basis of multiple sclerosis

scientific article published on 01 February 2011

Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis

scientific article published in July 2006

Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity

scientific article published in 2024

T lymphocytes conditioned with Interferon beta induce membrane and soluble VCAM on human brain endothelial cells

scientific article published in April 2001

TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.

scientific article

Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.

scientific article published on 19 June 2017

Th1 and Th2 lymphocyte migration across the human BBB is specifically regulated by interferon beta and copolymer-1.

scientific article published in March 2005

Th1 polarization of CD4+ T cells by Toll-like receptor 3-activated human microglia.

scientific article

The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence

scientific article

The IL-27/IL-27R axis is altered in CD4<sup>+</sup> and CD8<sup>+</sup> T lymphocytes from multiple sclerosis patients

scientific article published on 05 March 2021

The blood-brain barrier

scientific article

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells

scientific article published on 20 December 2007

Therapeutic decisions in multiple sclerosis: moving beyond efficacy

scientific article (publication date: October 2013)

Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in relapsing-remitting multiple sclerosis patients on high-dose interferon β.

scientific article

Timing of high-efficacy therapy for multiple sclerosis: a retrospective observational cohort study

scientific article published on 18 March 2020

Towards personalized therapy for multiple sclerosis: prediction of individual treatment response.

scientific article published in September 2017

Treatment effectiveness of alemtuzumab compared with natalizumab, fingolimod, and interferon beta in relapsing-remitting multiple sclerosis: a cohort study.

scientific article published on 10 February 2017

Treatment optimization in MS: Canadian MS Working Group updated recommendations.

scientific article published on May 2013

Treatment response score to glatiramer acetate or interferon beta-1a

scientific article published on 06 October 2020

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

scientific article published on 09 May 2016

USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation

scientific article published on 10 October 2016

Update on treatments in multiple sclerosis.

scientific article published on 23 March 2015

‘Cytokine defined’ B cell subsets in multiple sclerosis

scholarly article by Rui Li et al published October 2014 in Journal of Neuroimmunology

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