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List of works by Sean T Prigge

A key role for lipoic acid synthesis during Plasmodium liver stage development

scientific article published on 05 April 2013

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

scientific article published on 14 February 2020

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.

scientific article

Amidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenase

scientific article

Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae).

scientific article published on December 2010

Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum

scientific article published on 24 May 2017

Delivery of antimicrobials into parasites

scientific article

Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption.

scientific article

Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase

scientific article

Detection of pathogen-specific antibodies by loop-mediated isothermal amplification

scientific article

Development of a conditional localization approach to control apicoplast protein trafficking in malaria parasites.

scientific article published in August 2019

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides

scientific article

Differential Reactivity between Two Copper Sites in Peptidylglycine α-Hydroxylating Monooxygenase

scientific article

Dioxygen binds end-on to mononuclear copper in a precatalytic enzyme complex

scientific article

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay

scientific article published on 13 December 2013

Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase

scientific article published on 27 June 2003

Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase

scientific article

Fatty Acid synthesis as a target for antimalarial drug discovery.

scientific article

Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum

scientific article (publication date: 28 August 2002)

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

scientific article

Identification of an effector protein and gain-of-function mutants that activate Pfmrk, a malarial cyclin-dependent protein kinase

scientific article published on 15 May 2006

Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

scientific article

Inter-study and time-dependent variability of metabolite abundance in cultured red blood cells

scientific article published on 2 July 2021

Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.

scientific article published on 27 May 2011

Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener.

scientific article published on 23 April 2010

Lipoic acid metabolism in microbial pathogens.

scientific article

Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host.

scientific article

Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin

scientific article published on 18 March 2021

Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite

scientific article published on 27 February 2020

Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii

scientific article published on 14 June 2013

New insights into copper monooxygenases and peptide amidation: structure, mechanism and function

scientific article (publication date: August 2000)

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway

scientific article

Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents

scientific article published on 22 January 2013

Overexpression of biotin synthase and biotin ligase is required for efficient generation of sulfur-35 labeled biotin in E. coli ⬇️

scientific article published on October 11, 2010

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases

scientific article published in August 2003

Parasites FeS up: iron-sulfur cluster biogenesis in eukaryotic pathogens.

scientific article

Plasmodium falciparum apicoplast transit peptides are unstructured in vitro and during apicoplast import.

scientific article published on 7 July 2011

Plasmodium falciparumacyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth

scientific article

Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors.

scientific article

Redesigned TetR-Aptamer System To Control Gene Expression in Plasmodium falciparum

scientific article published on 12 August 2020

Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum

scientific article (publication date: October 2014)

Relation between positional specificity and chirality in mammalian lipoxygenases.

scientific article published on March 1998

Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum

scientific article (publication date: March 2007)

Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

scientific article published on 19 March 2019

Structure and mechanism of lipoxygenases.

scientific article published on November 1997

Structure, evolution, and inhibitor interaction of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum

scientific article published in September 2003

Studies ofToxoplasma gondiiandPlasmodium falciparumenoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

scientific article

Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase

scientific article

Targeting malaria with specific CDK inhibitors.

scientific article

Targeting the Lipid Metabolic Pathways for the Treatment of Malaria

scientific article

Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents

scientific article

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in plasmodium falciparum

scientific article published on 20 August 2020

The amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo

scientific article

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

scientific article

The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural role

scientific article

The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites

scientific article (publication date: 2013)

The tail of mycolic acids.

scientific article published in April 2008

Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure

scientific article

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