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List of works by Gillian Smith

A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models

article by Kaiming Sun et al published 14 December 2018 in Oncotarget

A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer

scientific article published in November 2002

A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

scientific article

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

scientific article published on 14 July 2016

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

scientific article published in July 1996

Can dietary furanocoumarin ingestion enhance the erythemal response during high-dose UVA1 therapy?

scientific article published on 14 September 2006

Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.

scientific article

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

scientific article published on 01 February 2006

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.

scientific article

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity

scientific article

Cytochrome P450 CYP2D6.

scientific article

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

scientific article (publication date: October 2001)

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity ⬇️

scientific article published on May 1, 1998

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

scientific article published on December 1995

Genetic factors associated with the aetiology and treatment of colorectal cancer

Genetic variants in XRCC2: new insights into colorectal cancer tumorigenesis

scientific article published on 18 August 2009

Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy

scientific article published on 01 April 2011

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

scientific article

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

scientific article published on 09 January 2012

Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)

scientific article published on February 1993

Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

scientific article

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations ⬇️

scientific article published on 9 February 2018

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

scientific article published in February 2003

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy.

scientific article published on 4 October 2007

Metabolic polymorphisms and cancer susceptibility.

scientific article published on January 1995

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

scientific article published on 14 August 2008

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms

scientific article published on April 2015

Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

scientific article

Pharmacogenetics

scientific article published on 01 January 1999

Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.

scientific article published on 28 January 2004

Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

scientific article published on 5 February 2008

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.

scientific article published on January 2003

Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk.

scientific article published in May 2010

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours ⬇️

scientific article published on June 28, 2011

Quantitative real-time reverse transcription-polymerase chain reaction analysis of drug metabolizing and cytoprotective genes in psoriasis and regulation by ultraviolet radiation.

scientific article published in August 2003

Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer ⬇️

scientific article

Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo.

scientific article

Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts

scientific article

Science, medicine, and the future: Pharmacogenetics

scientific article

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.

scientific article published on 20 April 2005

Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer

scientific article published in November 2004

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