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List of works by Aaron Schimmer

A 17-gene stemness score for rapid determination of risk in acute leukaemia

scientific article published on 7 December 2016

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

scientific article (publication date: November 2016)

A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.

scientific article published on 17 September 2007

A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis

scientific article (publication date: September 2007)

A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance.

scientific article

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

scientific article

A multicenter phase I/II study of obatoclax mesylate administered as a 3- or 24-hour infusion in older patients with previously untreated acute myeloid leukemia

scientific article

A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity

scientific article

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

scientific article

A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia

scientific article published on 6 July 2016

A phase I study of elesclomol sodium in patients with acute myeloid leukemia

scientific article published on 5 February 2016

A phase I study of the metal ionophore clioquinol in patients with advanced hematologic malignancies

scientific article published on 09 June 2012

A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies

scientific article published in December 2008

A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia

scientific article published on 12 July 2016

A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia.

scientific article

A phase I/II study of imatinib plus reinduction therapy for c-kit-positive relapsed/refractory acute myeloid leukemia: inhibition of Akt activation correlates with complete response

scientific article published on 15 March 2011

A phase II open-label study of aprepitant as anti-emetic prophylaxis in patients with acute myeloid leukemia (AML) undergoing induction chemotherapy

scientific article from 'Supportive Care in Cancer' published on 19 October 2018

A phase II study of temozolomide therapy for poor-risk patients aged >or=60 years with acute myeloid leukemia: low levels of MGMT predict for response

scientific article published on 25 January 2007

A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase

scientific article (publication date: 2014)

A retrospective observational study of leucoreductive strategies to manage patients with acute myeloid leukaemia presenting with hyperleucocytosis

scientific article

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

scientific article published on 6 December 2010

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

scientific article

AML refractory to primary induction with Ida-FLAG has a poor clinical outcome.

scientific article published on 20 February 2018

Abducted by the illness: a qualitative study of traumatic stress in individuals with acute leukemia

scientific article published on 24 January 2013

Acute promyelocytic leukemia in patients aged 70 years and over—A single center experience of unselected patients

scientific article published in January 2007

Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death

scientific article published on 28 June 2018

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

scientific article published on 05 May 2011

Allogeneic or autologous bone marrow transplantation (BMT) for non-Hodgkin's lymphoma (NHL): results of a provincial strategy. Ontario BMT Network, Canada.

scientific article

An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies ⬇️

scientific article published on March 14, 2013

Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.

scientific article

Apoptosis in leukemia: from molecular pathways to targeted therapies.

scientific article published on March 2008

Artificially Induced Protein–Membrane Anchorage with Cholesterol‐Based Recognition Agents as a New Therapeutic Concept ⬇️

scientific article published on July 4, 2011

Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in immunocompromised patients.

scientific article published on 29 September 2017

Assessment of the downstream portion of the mitochondrial pathway of caspase activation in patients with acute myeloid leukemia.

scientific article

Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123(+)/CD131(-) phenotype of leukemia stem cells.

scientific article published on 18 December 2015

BAD induces apoptosis in cells over-expressing Bcl-2 or Bcl-xL without loss of mitochondrial membrane potential.

scientific article published in July 2001

Bcl-B expression in human epithelial and nonepithelial malignancies

scientific article

Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen.

scientific article published on September 2006

Biological and clinical consequences of NPM1 mutations in AML.

scientific article published on 23 January 2017

Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

scientific article published on 16 February 2021

Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: 10-Color flow cytometry diagnosis and HyperCVAD therapy

scientific article published on 30 November 2015

Busulfan and cyclophosphamide as a preparative regimen for allogeneic blood and marrow transplantation in patients with non-Hodgkin's lymphoma.

scientific article published in January 2003

Carnitine transporter CT2 (SLC22A16) is over-expressed in acute myeloid leukemia (AML) and target knockdown reduces growth and viability of AML cells.

scientific article published on August 2015

Catalase activity and arsenic sensitivity in acute leukemia.

scientific article

Characteristics and outcomes of acute myelogenous leukemia patients with very late relapse (>5 years).

scientific article published in January 2007

Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria.

scientific article published on 11 November 2016

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

scientific article published on 9 July 2009

Clioquinol - a novel copper-dependent and independent proteasome inhibitor.

scientific article published on March 2011

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions

scientific article

Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation

scientific article

Crystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP: MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYME

scientific article

Cyproheptadine displays preclinical activity in myeloma and leukemia

scientific article published on 23 May 2008

Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells

scientific article published on 10 June 2008

Depression and hopelessness in patients with acute leukemia: the psychological impact of an acute and life-threatening disorder.

scientific article published on 18 September 2015

Dexamethasone increases ubiquitin transcription through an SP-1 dependent mechanism in multiple myeloma cells

scientific article published on 04 January 2008

Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid

scientific article published in September 2006

Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

scientific article

Distribution and Impact of Comorbidities on Survival and Leukemic Transformation in Myeloproliferative Neoplasm-Associated Myelofibrosis: A Retrospective Cohort Study.

scientific article published on 29 June 2017

Drug discovery in academia

scientific article published on 23 April 2015

Dysregulation of apoptosis genes in hematopoietic malignancies.

scientific article

Effect of Red Blood Cell Transfusion Dependence on the Natural History of Myeloproliferative Neoplasm-Associated Myelofibrosis

scientific article published on 21 September 2015

Effect of an antimicrobial stewardship programme on antimicrobial utilization and costs in patients with leukaemia: a retrospective interventional controlled study.

scientific article published on 11 November 2017

Effect of noncompetitive proteasome inhibition on bortezomib resistance

scientific article

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

scientific article published on September 2016

Expression of CD4 is correlated with an unfavorable prognosis in wild-type NPM1, FLT3-ITD-negative cytogenetically normal adult acute myeloid leukemia.

scientific article

FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing.

scientific article

Feasibility of outpatient consolidation chemotherapy in older versus younger patients with acute myeloid leukemia

scientific article published on 27 December 2011

Finding new bearings: a qualitative study on the transition from inpatient to ambulatory care of patients with acute myeloid leukemia.

scientific article

Global profiles of gene expression induced by adrenocorticotropin in Y1 mouse adrenal cells

scientific article published on 16 February 2006

Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosis

scientific article (publication date: 2012)

Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer

scientific article

High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission

scientific article published on 26 January 2013

Higher ratio immune versus constitutive proteasome level as novel indicator of sensitivity of pediatric acute leukemia cells to proteasome inhibitors

scientific article published on 20 September 2013

Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism

scientific article published on 27 November 2015

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

scientific article

Identification of NAE Inhibitors Exhibiting Potent Activity in Leukemia Cells: Exploring the Structural Determinants of NAE Specificity

scientific article published on 16 May 2011

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

scientific article

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo

scientific article

Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity

scientific article

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

scientific article

Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.

scientific article

Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.

scientific article published on 23 September 2011

Increased efficiency for performing colony formation assays in 96-well plates: novel applications to combination therapies and high-throughput screening

scientific article

Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells.

scientific article

Increased pressure alters plasma membrane dynamics and renders acute myeloid leukemia cells resistant to daunorubicin

scientific article published on 16 July 2015

Induction of apoptosis in lymphoid and myeloid leukemia.

scientific article published on November 2006

Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia

scientific article published on 26 June 2012

Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.

scientific article published on 13 September 2013

Inhibition of SREBP1 sensitizes cells to death ligands.

scientific article

Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity.

scientific article published on 15 January 2013

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

scientific article published on November 2011

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

scientific article published on June 2015

Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation

scientific article

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

scientific article

Investigating the synergistic mechanism between ibrutinib and daunorubicin in acute myeloid leukemia cells

scientific article published on 17 February 2016

Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML.

scientific article published on 10 March 2017

Long-term outcomes in adult patients below the age of 55 years with acute lymphoblastic leukemia treated with chemotherapy or allogeneic BM transplant in first CR

scientific article published on 16 November 2009

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

scientific article

MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells

scientific article published in Nature Communications

Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux

scientific article published on 15 February 2022

Mapping the cellular response to small molecules using chemogenomic fitness signatures

scientific article

Metabolic Flexibility in Leukemia-Adapt or Die

scientific article published on 01 November 2018

Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells

scientific article

Mitochondria regulate AML differentiation independent of oxidative phosphorylation and metabolism

scientific article published on 28 September 2020

Mitochondrial DNA damage by bleomycin induces AML cell death

scientific article

Mitochondrial Shapeshifting Impacts AML Stemness and Differentiation

scientific article published on 01 July 2018

Mitochondrial Targeting of Doxorubicin Eliminates Nuclear Effects Associated with Cardiotoxicity

scientific article published on 18 June 2015

Mitochondrial matrix proteases as novel therapeutic targets in malignancy.

scientific article published on 17 June 2013

Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells

scientific article

New sources of drugs for hematologic malignancies

scientific article

Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo.

scientific article published on 8 November 2008

Novel Mitochondrial Mechanisms of Cytarabine Resistance in Primary AML Cells.

scientific article published in July 2017

Novel proteasome inhibitors to overcome bortezomib resistance

scientific article published on 23 May 2011

Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia

scientific article published on 29 October 2018

Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies

scientific article published on 03 March 2014

Outcome of patients who develop acute leukemia or myelodysplasia as a second malignancy after solid tumors treated surgically or with strategies that include chemotherapy and/or radiation

scientific article published in 2008

Outcomes of adult patients with relapsed acute lymphoblastic leukemia following frontline treatment with a pediatric regimen

scientific article published on 30 August 2012

Outcomes of older patients (> or = 60 years) with acquired aplastic anaemia treated with immunosuppressive therapy.

scientific article

Ovarian function after autologous bone marrow transplantation ⬇️

scientific article published on July 1, 1998

Pain in patients with newly diagnosed or relapsed acute leukemia

scientific article published on 08 December 2018

Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia

scientific article published on 03 August 2009

Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis

scientific article

Phorbol ester impairs melanotropin receptor function and stimulates growth of cultured M2R melanoma cells

scientific article published on 01 March 1989

Phosphopeptide selective coordination complexes as promising SRC homology 2 domain mimetics

scientific article

Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent

scientific article

Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer

scientific article

Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia

scientific article published on 08 June 2018

Predictive value of molecular remissions postconsolidation chemotherapy in patients with Core Binding Factor Acute Myeloid Leukemia (CBF-AML) - a single center analysis

scientific article published on 6 September 2016

Predictors of outcome in adults with BCR-ABL negative acute lymphoblastic leukemia treated with a pediatric-based regimen.

scientific article

Predictors of response to reinduction chemotherapy for patients with acute myeloid leukemia who do not achieve complete remission with frontline induction chemotherapy

scientific article published on 01 January 2008

Prevalence of oral lesions in and dental needs of patients with newly diagnosed acute leukemia

scientific article published on 30 March 2018

Prognostic Effect of Complex Karyotype, Monosomal Karyotype, and Chromosome 17 Abnormalities in B-Cell Acute Lymphoblastic Leukemia

scientific article published on 17 February 2017

Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer.

scientific article

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

scientific article published on 29 August 2016

RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs

scientific article

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism

scientific article

Re-evaluation of acute erythroid leukemia according to the 2016 WHO classification

scientific article published on 25 August 2017

Remissions after third induction chemotherapy for primary non-responders with acute myeloid leukemia (AML) are uncommon and short-lived.

scientific article

Rerouting chlorambucil to mitochondria combats drug deactivation and resistance in cancer cells

scientific article published on April 2011

SBDS-deficiency results in specific hypersensitivity to Fas stimulation and accumulation of Fas at the plasma membrane

scientific article published on 01 January 2009

SBDS-deficient cells undergo accelerated apoptosis through the Fas-pathway.

scientific article published on 11 February 2008

Safety of therapeutic anticoagulation in patients with multiple myeloma receiving autologous stem cell transplantation.

scientific article

Salvage induction chemotherapy after azacitdine treatment failure in patients who received azacitidine as a bridge to allogeneic stem cell transplantation

scientific article published on 21 March 2014

Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells

scientific article published on July 2015

Self-concept as a "BMT patient", illness intrusiveness, and engulfment in allogeneic bone marrow transplant recipients.

scientific article

Sharing post-AML consolidation supportive therapy with local centers reduces patient travel burden without compromising outcomes.

scientific article

Suppression of cancer progression by MGAT1 shRNA knockdown.

scientific article

Symptom burden and supportive care in patients with acute leukemia ⬇️

scientific article published on March 11, 2013

Synchronous T lymphoblastic lymphoma and myeloid neoplasm with PDGFRA rearrangement

scientific article published on 25 December 2016

TROSY-based NMR evidence for a novel class of 20S proteasome inhibitors

scientific article

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

scientific article published in June 2015

Targeting mitochondrial RNA polymerase in acute myeloid leukemia.

scientific article

Targeting neurolysin in acute myeloid leukemia

scientific article published on 23 May 2020

Targeting nuclear import and export in hematological malignancies

scientific article published on 05 July 2020

Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma

scientific article

Targeting the IAP family of caspase inhibitors as an emerging therapeutic strategy.

scientific article

Targeting the Ubiquitin E1 as a Novel Anti-Cancer Strategy ⬇️

scientific article published on January 1, 2013

The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2

scientific article published in July 2001

The Canadian Choosing Wisely campaign: the Canadian Hematology Society's top five tests and treatments

scientific article

The Experience of Medical Communication in Adults with Acute Leukemia: Impact of Age and Attachment Security

scientific article published on 12 November 2018

The Tricyclic Antidepressant Amitriptyline Inhibits d-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence ⬇️

scientific article published on January 10, 2011

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

scientific article published on 26 March 2010

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

scientific article published on 19 July 2010

The importance of meaningful activity in people living with acute myeloid leukemia

scientific article published on 15 February 2018

The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability

scientific article published on 01 April 2020

The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway.

scientific article

The prognostic impact of FLT3-ITD and NPM1 mutations in patients with relapsed acute myeloid leukemia and intermediate-risk cytogenetics.

scientific article published on 24 May 2013

The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy ⬇️

scientific article published on August 24, 2010

The role of mitochondrial proteases in leukemic cells and leukemic stem cells

scientific article published on 05 August 2020

The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.

scientific article published on 29 January 2016

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

scientific article

Therapeutic potential of mitochondrial translation inhibition for treatment of acute myeloid leukemia

scientific article published on 01 April 2012

Traumatic stress in acute leukemia ⬇️

scientific article published on November 13, 2011

Traumatic stress in patients with acute leukemia: A prospective cohort study

scientific article

Treatment of Philadelphia chromosome‐positive acute lymphoblastic leukaemia with imatinib combined with a paediatric‐based protocol ⬇️

scientific article published on June 1, 2012

Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimen

scientific article published on 4 May 2009

Treatment of elderly patients with acute lymphoblastic leukaemia using a paediatric-based protocol

scientific article published on 13 September 2013

Treatment outcomes following leukemic transformation in Philadelphia-negative myeloproliferative neoplasms.

scientific article published on 29 January 2013

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer

scientific article published on January 2011

Venous thromboembolism prevention during asparaginase-based therapy for acute lymphoblastic leukemia

scientific article published on 12 August 2016

Want fries with that? Antimyeloma drug combos ⬇️

scientific article published on July 29, 2010

Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers.

scientific article

α-Boryl isocyanides enable facile preparation of bioactive boropeptides.

scientific article published in July 2013

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