List of works by Edward W. Tate

A New Chemical Handle for Protein AMPylation at the Host-Pathogen Interface

scientific article published on 02 January 2012

A caged E3 ligase ligand for PROTAC-mediated protein degradation with light

scientific article published on 16 April 2020

A highly enantioselective total synthesis of (+)-goniodiol

scientific article published on 27 March 2006

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation

scientific article published in 2024

A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei

scientific article published on 15 May 2012

A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5.

scientific article published on July 2014

AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Activity-Based Profiling for Drug Discovery

scientific article published on 01 April 2011

Activity-Based Protein Profiling for the Study of Parasite Biology

scientific article published on 01 January 2019

Activity-based probes: discovering new biology and new drug targets ⬇️

scientific article published on October 1, 2010

Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes

scientific article published on 01 July 2019

Application of activity-based protein profiling to the study of microbial pathogenesis

scientific article published on January 2012

Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

scientific article

Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation.

scientific article

BFSP1 C-terminal domains released by post-translational processing events can alter significantly the calcium regulation of AQP0 water permeability

scientific article published on 18 February 2019

Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain

scientific article published on 11 December 2019

Bioorthogonal chemical tagging of protein cholesterylation in living cells

scientific article published on 11 January 2011

Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.

scientific article published on 12 March 2018

CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering

scientific article published on 01 June 2020

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells

scientific article published on 25 October 2016

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

scientific article published on 6 March 2008

Chemical biology tools for probing transcytosis at the blood-brain barrier

scientific article published on 08 October 2019

Chemical proteomics: a powerful tool for exploring protein lipidation.

scientific article published on February 2013

Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid

scientific article published on 16 June 2015

Cholesterylation: a tail of hedgehog

scientific article published on April 2015

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.

scientific article

Comparing experimental and computational alanine scanning techniques for probing a prototypical protein–protein interaction

scientific article published on 23 July 2010

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

scientific article published on 25 April 2017

Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.

scientific article

Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a

scientific article published on 28 February 2019

Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity"

scientific article published on 19 August 2020

Correction: Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain

scientific article published on 29 April 2020

Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors

scientific article published on 06 May 2015

Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions

scientific article

Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction

scientific article

D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition

scientific article published on 16 March 2020

Demographic, Clinical, and Immunologic Features of 389 Children with Opsoclonus-Myoclonus Syndrome: A Cross-sectional Study.

scientific article published on 11 September 2017

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity

scientific article published on 28 September 2018

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

scientific article

Design and Synthesis of Inhibitors of Plasmodium falciparumN -Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery

scientific article

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.

scientific article

Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.

scientific article

Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design

scientific article published on 19 July 2016

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferase

scientific article

Discovery of Plasmodium vivax N -Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

scientific article

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

scientific article published on 19 August 2015

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

scientific article published on 19 August 2015

Diverse modes of binding in structures ofLeishmania majorN-myristoyltransferase with selective inhibitors

scientific article

Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics

scientific article published on 01 April 2019

Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets.

scientific article

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.

scientific article

Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation

scientific article (publication date: 9 July 2014)

Getting a chemical handle on proteinpost-translational modification

article

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei ⬇️

scientific article

Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach

scientific article published on 24 November 2015

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani ⬇️

scientific article

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells ⬇️

scientific article

Global profiling of protein lipidation using chemical proteomic technologies

scientific article

High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.

scientific article published on 26 February 2018

High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation

scientific article published on 28 February 2020

High-yielding F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo

scholarly article by Rhiannon Beard et al published 17 July 2018 in Chemical Communications

Highlights from the 46th EUCHEM Conference on stereochemistry, Bürgenstock, Switzerland, May 2011

article

Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins

scientific article published in July 2007

Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions

scientific article published on 17 July 2019

Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite

scientific article

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor

scientific article

Membrane bound O-acyltransferases and their inhibitors.

scientific article published on April 2015

Membrane enhanced peptide synthesis

scientific article published on 02 March 2010

Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation

Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines

scientific article published on 9 April 2015

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

scientific article published in December 2007

Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology.

scientific article

Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry

scientific article published on 22 December 2011

Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development

scientific article published on 25 March 2015

Myristoylation profiling in human cells and zebrafish

scientific article published on 2 July 2015

N-Myristoyl transferase-mediated protein labelling in vivo

scientific article published on 12 May 2008

N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action

scientific article published on 24 January 2018

N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells

scientific article published on 7 June 2016

N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis

scientific article published on 24 April 2013

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

scientific article

N-myristoyltransferase: a prospective drug target for protozoan parasites

scientific article published on March 2008

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish

scientific article

New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness ⬇️

scientific article published on 8 March 2017

Novel inhibitors of surface layer processing in Clostridium difficile

article

Open Source High Content Analysis Utilizing Automated Fluorescence Lifetime Imaging Microscopy.

scientific article published on 18 January 2017

Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex

scientific article published on 08 May 2020

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

scientific article

Pharmacological inhibition of PARP6 triggers multipolar spindle formation and elicits therapeutic effects in breast cancer

scientific article published on 08 October 2018

Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions

scientific article published on 17 October 2018

Photoactive Bifunctional Degraders: Precision Tools To Regulate Protein Stability

scientific article published on 23 November 2020

Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces

scientific article published in Journal of Biological Chemistry

Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II.

scientific article published on 3 April 2014

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

scientific article published in October 2009

Protein myristoylation in health and disease

scientific article published on 7 November 2009

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells

scientific article published on 31 October 2016

Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation

scientific article published on 12 November 2015

Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins

scientific article published on 13 July 2020

Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs

scientific article published on 19 March 2020

Regulation of the Plasmodium Motor Complex: PHOSPHORYLATION OF MYOSIN A TAIL-INTERACTING PROTEIN (MTIP) LOOSENS ITS GRIP ON MyoA

scientific article

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs

scientific article

Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.

scientific article

Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation

scientific article published on 25 June 2008

Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes

scientific article published on 20 September 2019

Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors

scientific article published on 10 February 2020

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors

scientific article published on 09 May 2019

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors

scientific article published on October 2014

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

scientific article published on 11 November 2016

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

scientific article published on 10 February 2016

Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity.

scientific article published in February 2015

Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics

scientific article

Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics

scientific article published on 01 March 2015

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

scientific article published on 30 May 2020

Targeting a dynamic protein-protein interaction: fragment screening against the malaria myosin A motor complex

scientific article published on 3 November 2014

The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain

scientific article (publication date: 8 May 2015)

The Rab-binding Profiles of Bacterial Virulence Factors during Infection

scientific article published on 11 January 2016

Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.

scientific article published on 26 September 2015

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.

scientific article

Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein

scientific article

Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II

scientific article published on 01 July 2006

Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite

scientific article (publication date: 2013)

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes

scientific article (publication date: December 2014)

Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases

scientific article published on 18 April 2019

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach ⬇️

scientific article

Whole proteome profiling of -myristoyltransferase activity and inhibition using Sortase-A

scientific article published on 19 October 2018

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