List of works - Federica Forbici

'Sentinel' mutations in standard population sequencing can predict the presence of HIV-1 reverse transcriptase major mutations detectable only by ultra-deep pyrosequencing.

scientific article published on 2 September 2011

A very low geno2pheno false positive rate is associated with poor viro-immunological response in drug-naïve patients starting a first-line HAART

scientific article

Ability of two commercially available assays (Abbott RealTime HIV-1 and Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Version 2.0) to quantify low HIV-1 RNA Levels (<1,000 copies/milliliter): comparison with clinical samples and NIBSC working reagent for

scientific article

Characterisation of HIV-1 molecular transmission clusters among newly diagnosed individuals infected with non-B subtypes in Italy

scientific article published on 10 May 2019

Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of resistance to nonnucleoside inhibitors

scientific article

Clinical and genotypic correlates of mutation K65R in HIV-infected patients failing regimens not including tenofovir

article

Clinical implications of HIV-1 drug resistance in the neurological compartment.

scientific article published on January 2003

Clinical validation and applicability of different tipranavir/ritonavir genotypic scores in HIV-1 protease inhibitor-experienced patients

scientific article published in July 2009

Comparative Evaluation of Subtyping Tools for Surveillance of Newly Emerging HIV-1 Strains

scientific article published on 12 July 2017

Comparative analysis of drug resistance among B and the most prevalent non-B HIV type 1 subtypes (C, F, and CRF02_AG) in Italy

scientific article

Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure

scientific article published in August 2002

Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens

scientific article published on November 2010

Docking analysis and resistance evaluation of clinically relevant mutations associated with the HIV-1 non-nucleoside reverse transcriptase inhibitors nevirapine, efavirenz and etravirine

scientific article published on 27 September 2011

Drug-class-wide resistance to antiretrovirals in HIV-infected patients failing therapy: prevalence, risk factors and virological outcome

article

Drug-resistance development differs between HIV-1-infected patients failing first-line antiretroviral therapy containing nonnucleoside reverse transcriptase inhibitors with and without thymidine analogues

scientific article published on 13 May 2013

Dynamics of NRTI Resistance Mutations during Therapy Interruption

article

Effect of Suppressing HIV Viremia on the HIV Progression of Patients Undergoing a Genotype Resistance Test after Treatment Failure

article

Efficacy of cerebrospinal fluid (CSF)-penetrating antiretroviral drugs against HIV in the neurological compartment: different patterns of phenotypic resistance in CSF and plasma

scientific article

Fast and sensitive quantitative detection of HIV DNA in whole blood leucocytes by SYBR green I real-time PCR assay

scientific article published on 21 May 2007

Genotypic resistance test in proviral DNA can identify resistance mutations never detected in historical genotypic test in patients with low level or undetectable HIV-RNA.

scientific article published on 18 July 2016

HIV-1 drug resistance in recently HIV-infected pregnant mother's naïve to antiretroviral therapy in Dodoma urban, Tanzania

scientific article

HIV-1 integrase genotyping is reliable and reproducible for routine clinical detection of integrase resistance mutations even in patients with low-level viraemia

scientific article published on 23 February 2015

Historical resistance profile helps to predict salvage failure.

scientific article published on January 2009

Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure

scientific article

Impact of pre-therapy viral load on virological response to modern first-line HAART.

scientific article published on 23 January 2013

Increasing prevalence of non-clade B HIV-1 strains in heterosexual men and women, as monitored by analysis of reverse transcriptase and protease sequences

scientific article

Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of azidothymidine and 9-(R)-2-(phosphono methoxypropyl)adenine

scientific article published in May 2001

Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors

scientific article

Is extended resistance to the historical antiretroviral drugs & drug classes still a risk factor for HIV progression?

scientific article

Macrophages: a crucial reservoir for human immunodeficiency virus in the body.

scientific article

Minor mutations in HIV protease at baseline and appearance of primary mutation 90M in patients for whom their first protease-inhibitor antiretroviral regimens failed

scientific article

Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients

scientific article published in July 2005

Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort

scientific article published on 13 April 2004

Plasma HIV RNA Decline and Emergence of Drug Resistance Mutations among Patients with Multiple Virologic Failures Receiving Resistance Testing-Guided HAART

article

Pre-existent NRTI and NNRTI resistance impacts on maintenance of virological suppression in HIV-1-infected patients who switch to a tenofovir/emtricitabine/rilpivirine single-tablet regimen

scientific article published on 20 December 2016

Primary HIV-1 resistance in recently and chronically infected individuals of the Italian Cohort Naive for Antiretrovirals.

scientific article published on January 2002

Q151M-mediated multinucleoside resistance: prevalence, risk factors, and response to salvage therapy

scientific article

Recent Transmission Clustering of HIV-1 C and CRF17_BF Strains Characterized by NNRTI-Related Mutations among Newly Diagnosed Men in Central Italy

scientific article

Reliability and clinical relevance of the HIV-1 drug resistance test in patients with low viremia levels

scientific article published on 14 January 2014

Resistance detected in PBMCs predicts virological rebound in HIV-1 suppressed patients switching treatment

scientific article published on 03 April 2018

Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy

scientific article published on 30 August 2001

Subtype analysis and mutations to antiviral drugs in HIV-1-infected patients from Mozambique before initiation of antiretroviral therapy: results from the DREAM programme

scientific article

Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy

article

The V118I mutation as a marker of advanced HIV infection and disease progression

article

The effect of number of mutations and of drug-class sparing on virological response to salvage genotype-guided antiretroviral therapy.

scientific article published in December 2003

The genotypic false positive rate determined by V3 population sequencing can predict the burden of HIV-1 CXCR4-using species detected by pyrosequencing

scientific article

The lowest X4 Geno2Pheno false-positive rate is associated with greater CD4 depletion in HIV-1 infected patients.

scientific article published on 8 June 2012

Use of novel antiretroviral agents in rescue regimens: a case of early virological failure to raltegravir

scientific article published in March 2010

Using a database of HIV patients undergoing genotypic resistance test after HAART failure to understand the dynamics of M184V mutation.

scientific article published in February 2003

Viral dynamics and mutations in the pol gene during primary HIV-1 infection

article

Virologic correlates of adherence to antiretroviral medications and therapeutic failure.

scientific article

Virological response and resistance profile in HIV-1-infected patients starting darunavir-containing regimens.

scientific article published on 28 June 2016

List of works by Federica Forbici

'Sentinel' mutations in standard population sequencing can predict the presence of HIV-1 reverse transcriptase major mutations detectable only by ultra-deep pyrosequencing.

A very low geno2pheno false positive rate is associated with poor viro-immunological response in drug-naïve patients starting a first-line HAART

Ability of two commercially available assays (Abbott RealTime HIV-1 and Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Version 2.0) to quantify low HIV-1 RNA Levels (<1,000 copies/milliliter): comparison with clinical samples and NIBSC working reagent for

Characterisation of HIV-1 molecular transmission clusters among newly diagnosed individuals infected with non-B subtypes in Italy

Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of resistance to nonnucleoside inhibitors

Clinical and genotypic correlates of mutation K65R in HIV-infected patients failing regimens not including tenofovir

Clinical implications of HIV-1 drug resistance in the neurological compartment.

Clinical validation and applicability of different tipranavir/ritonavir genotypic scores in HIV-1 protease inhibitor-experienced patients

Comparative Evaluation of Subtyping Tools for Surveillance of Newly Emerging HIV-1 Strains

Comparative analysis of drug resistance among B and the most prevalent non-B HIV type 1 subtypes (C, F, and CRF02_AG) in Italy

Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure

Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens

Docking analysis and resistance evaluation of clinically relevant mutations associated with the HIV-1 non-nucleoside reverse transcriptase inhibitors nevirapine, efavirenz and etravirine

Drug-class-wide resistance to antiretrovirals in HIV-infected patients failing therapy: prevalence, risk factors and virological outcome

Drug-resistance development differs between HIV-1-infected patients failing first-line antiretroviral therapy containing nonnucleoside reverse transcriptase inhibitors with and without thymidine analogues

Dynamics of NRTI Resistance Mutations during Therapy Interruption

Effect of Suppressing HIV Viremia on the HIV Progression of Patients Undergoing a Genotype Resistance Test after Treatment Failure

Efficacy of cerebrospinal fluid (CSF)-penetrating antiretroviral drugs against HIV in the neurological compartment: different patterns of phenotypic resistance in CSF and plasma

Fast and sensitive quantitative detection of HIV DNA in whole blood leucocytes by SYBR green I real-time PCR assay

Genotypic resistance test in proviral DNA can identify resistance mutations never detected in historical genotypic test in patients with low level or undetectable HIV-RNA.

HIV-1 drug resistance in recently HIV-infected pregnant mother's naïve to antiretroviral therapy in Dodoma urban, Tanzania

HIV-1 integrase genotyping is reliable and reproducible for routine clinical detection of integrase resistance mutations even in patients with low-level viraemia

Historical resistance profile helps to predict salvage failure.

Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure

Impact of pre-therapy viral load on virological response to modern first-line HAART.

Increasing prevalence of non-clade B HIV-1 strains in heterosexual men and women, as monitored by analysis of reverse transcriptase and protease sequences

Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of azidothymidine and 9-(R)-2-(phosphono methoxypropyl)adenine

Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors

Is extended resistance to the historical antiretroviral drugs & drug classes still a risk factor for HIV progression?

Macrophages: a crucial reservoir for human immunodeficiency virus in the body.

Minor mutations in HIV protease at baseline and appearance of primary mutation 90M in patients for whom their first protease-inhibitor antiretroviral regimens failed

Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients

Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort

Plasma HIV RNA Decline and Emergence of Drug Resistance Mutations among Patients with Multiple Virologic Failures Receiving Resistance Testing-Guided HAART

Pre-existent NRTI and NNRTI resistance impacts on maintenance of virological suppression in HIV-1-infected patients who switch to a tenofovir/emtricitabine/rilpivirine single-tablet regimen

Primary HIV-1 resistance in recently and chronically infected individuals of the Italian Cohort Naive for Antiretrovirals.

Q151M-mediated multinucleoside resistance: prevalence, risk factors, and response to salvage therapy

Recent Transmission Clustering of HIV-1 C and CRF17_BF Strains Characterized by NNRTI-Related Mutations among Newly Diagnosed Men in Central Italy

Reliability and clinical relevance of the HIV-1 drug resistance test in patients with low viremia levels

Resistance detected in PBMCs predicts virological rebound in HIV-1 suppressed patients switching treatment

Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy

Subtype analysis and mutations to antiviral drugs in HIV-1-infected patients from Mozambique before initiation of antiretroviral therapy: results from the DREAM programme

Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy

The V118I mutation as a marker of advanced HIV infection and disease progression

The effect of number of mutations and of drug-class sparing on virological response to salvage genotype-guided antiretroviral therapy.

The genotypic false positive rate determined by V3 population sequencing can predict the burden of HIV-1 CXCR4-using species detected by pyrosequencing

The lowest X4 Geno2Pheno false-positive rate is associated with greater CD4 depletion in HIV-1 infected patients.

Use of novel antiretroviral agents in rescue regimens: a case of early virological failure to raltegravir

Using a database of HIV patients undergoing genotypic resistance test after HAART failure to understand the dynamics of M184V mutation.

Viral dynamics and mutations in the pol gene during primary HIV-1 infection

Virologic correlates of adherence to antiretroviral medications and therapeutic failure.

Virological response and resistance profile in HIV-1-infected patients starting darunavir-containing regimens.