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List of works by Masaaki Komatsu

A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane

scientific article

A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease

scientific article published on 8 February 2009

A novel approach to assess the ubiquitin-fold modifier 1-system in cells

scientific article published on 7 December 2016

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy

scientific article published on April 2009

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

scientific article

A novel type of E3 ligase for the Ufm1 conjugation system

scientific article

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

scientific article

A treadmill exercise reactivates the signaling of the mammalian target of rapamycin (mTor) in the skeletal muscles of starved mice

scientific article

Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.

scientific article

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

scientific article

Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy

scientific article published on February 2011

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

scientific article

Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.

scientific article published on 17 May 2017

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.

scientific article published in March 2018

Autophagy Induced by Calcium Phosphate Precipitates Involves Endoplasmic Reticulum Membranes in Autophagosome Biogenesis ⬇️

scientific article published on December 21, 2012

Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus

scientific article

Autophagy and neurodegeneration.

scientific article

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

scientific article published on 28 January 2019

Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

scientific article published on 11 November 2011

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

scientific article published on 02 December 2012

Autophagy in proximal tubules protects against acute kidney injury

scientific article

Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation

article

Autophagy in the liver: functions in health and disease

scientific article published on 5 January 2017

Autophagy is essential for mitochondrial clearance in mature T lymphocytes

scientific article published in April 2009

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

scientific article published on October 2008

Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro

scientific article published on 7 January 2011

Autophagy is involved in regulating influenza A virus RNA and protein synthesis associated with both modulation of Hsp90 induction and mTOR/p70S6K signaling pathway

scientific article published on 18 January 2016

Autophagy is required to maintain muscle mass

scientific article published in December 2009

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain

scientific article published on 20 September 2016

Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor

scientific article

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

scientific article published on 10 September 2015

Autophagy regulates lipid metabolism

scientific article

Autophagy regulates phagocytosis by modulating the expression of scavenger receptors

scientific journal article

Autophagy-deficient mice develop multiple liver tumors

scientific article published on April 2011

Autophagy-monitoring and autophagy-deficient mice

scientific article published on 18 August 2017

Autophagy: Renovation of Cells and Tissues ⬇️

scientific article (publication date: 11 November 2011)

Autophagy: more than a nonselective pathway

scientific article published on 15 May 2012

Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy

scientific article published on 17 August 2016

Biochemical and morphological detection of inclusion bodies in autophagy-deficient mice

scientific article published in January 2009

Chapter 14 Method for Monitoring Pexophagy in Mammalian Cells

scientific article published on 01 January 2009

Cloning and characterization of two neural-salient serine/arginine-rich (NSSR) proteins involved in the regulation of alternative splicing in neurones.

scientific article

Comprehensive proteomics analysis of autophagy-deficient mouse liver

scientific article published on 04 February 2008

Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons.

scientific article published on 2 March 2007

Crucial role for autophagy in degranulation of mast cells

scientific article published on 18 February 2011

Crystal structure of Ufc1, the Ufm1-conjugating enzyme

scientific article

Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin.

scientific article

DNA damage response and sphingolipid signaling in liver diseases

scientific article

Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy.

scientific article published in February 2008

Discovery of Atg5/Atg7-independent alternative macroautophagy

scientific article

Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor

scientific article published on 6 October 2017

Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

scientific article

Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy

scientific article published in February 2014

Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells

scientific article

Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria.

scientific article published on 21 November 2013

Erratum

scholarly article published in Autophagy

Erratum: Corrigendum: Discovery of Atg5/Atg7-independent alternative macroautophagy

scientific article published in Nature

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

scientific journal article

Excess peroxisomes are degraded by autophagic machinery in mammals

scientific article

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

scientific article

Functions of autophagy in normal and diseased liver

scientific article published on 22 May 2013

GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3

scientific article

GENETIC MOUSE MODELS FOR ELUCIDATION OF AUTOPHAGY-LYSOSOMAL SYSTEMS IN NEURONS UNDER PHYSIOLOGIC AND PATHOLOGIC CONDITIONS

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation

scientific article published on 01 March 2020

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

scientific article

Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p

scientific article

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

scientific article

Impaired G1-Arrest, Autophagy, and Apoptosis in Atg7 -Knockout Mice

scientific article published on 01 September 2012

Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis

scientific article

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

scientific journal article

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury

scientific article published on 12 January 2016

Inducible disruption of autophagy in the lung causes airway hyper-responsiveness

scientific article published on 23 December 2010

Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin

scientific article published on 10 December 2014

Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma

scientific article published on November 2016

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

scientific article published on 10 January 2008

Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line

scientific article published on 30 March 2020

Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells

scientific article

Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart

scientific article published on 14 March 2013

Keap1 degradation by autophagy for the maintenance of redox homeostasis

scientific article

L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease

scientific article published on 21 November 2017

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

scientific article published on 28 September 2020

LC3B is indispensable for selective autophagy of p62 but not basal autophagy

scientific article published on 28 February 2014

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation

scientific article

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

scientific article

Liver autophagy: physiology and pathology ⬇️

scientific article published on June 1, 2012

Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation

scientific article published on 10 April 2008

Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia

scientific article published on October 2008

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

scientific article published on 26 December 2019

Loss of autophagy in chondrocytes causes severe growth retardation

scientific article published on 16 June 2019

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

scientific article published on 12 February 2018

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

scientific journal article

Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation

scientific article published on 26 January 2012

Loss of autophagy in the central nervous system causes neurodegeneration in mice

scientific article (publication date: 15 June 2006)

Loss of autophagy promotes murine acetaminophen hepatotoxicity

scientific article published on 29 November 2011

MAZ, a Myc-associated zinc finger protein, is essential for the ME1a1-mediated expression of the c-myc gene during neuroectodermal differentiation of P19 cells.

scientific article published in September 1997

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

scientific article

Mechanisms of necroptosis in T cells

scientific journal article

Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease

scientific article

Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells

scientific article

Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development

scientific article

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

scientific article

Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs

scientific article (publication date: 22 March 2002)

NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system

scientific article published on 09 January 2020

Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant.

scientific article published on 16 January 2018

Neuronal autophagy: going the distance to the axon.

scientific article published on 23 October 2007

No ATG is an island--the connection of autophagy with diverse pathways and functions

scientific article published on 15 February 2012

Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance

scientific article published on 23 May 2016

Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions

scientific article

Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway

scientific article

PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis

scientific journal article

PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation

scientific article

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

scientific article

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

scientific article (publication date: 19 April 2010)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

scientific article published in March 2018

Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models

scientific article published on January 2011

Pathophysiological roles of autophagy ⬇️

scientific article published on 01 November 2011

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

scientific article

Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity

scientific article published on 12 November 2021

Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16

scientific article

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy

scientific article

Physiological significance of selective degradation of p62 by autophagy

scientific article published on 12 February 2010

Potential role of p62 in tumor development ⬇️

scientific article published on September 1, 2011

Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway

scientific article published on 21 July 2014

Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates

scientific article

Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.

scientific article published on 11 May 2017

Receptor protein complexes are in control of autophagy

scientific article

Regulation of the Keap1–Nrf2 pathway by p62/SQSTM1

Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response

scientific article published on 14 February 2012

Selective autophagy regulates various cellular functions

scientific article published on 28 July 2010

Selective degradation of p62 by autophagy

scientific article published on 03 September 2010

Selective turnover of p62/A170/SQSTM1 by autophagy

scientific article published on 20 November 2008

Selective types of autophagy

scientific article published on 21 August 2012

Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice

scientific article published on 20 June 2016

Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1.

scientific article

Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells

scientific article published on 19 October 2015

Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation

scientific article published on 29 February 2016

Structural basis for sorting mechanism of p62 in selective autophagy

scientific article

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures

scientific article

Structure of Ubiquitin-fold Modifier 1-specific Protease UfSP2

scientific article

Suppression of autophagy in osteocytes mimics skeletal aging

scientific article published on 03 May 2013

Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder--murine Pompe disease

scientific article

Suppression of autophagy sensitizes Kupffer cells to endotoxin.

scientific article

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity

scientific article published on 27 October 2016

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes

scientific article published in Nature Communications

The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice

scientific article

The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation

scientific article

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function

scientific article published on 6 February 2018

The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels

scientific article

The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation

scientific article published in January 2012

The MAP1-LC3 conjugation system is involved in lipid droplet formation

scientific article published on 13 March 2009

The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice

scientific article

The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

scientific article published on 06 February 2009

The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers

scientific article

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

scientific article

The significant role of autophagy in the granular layer in normal skin differentiation and hair growth

scientific article

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.

scientific article published on 20 January 2015

Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress

scientific article

Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy

scientific article published on 26 March 2014

Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways

scientific article published on 20 September 2017

Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2

scientific journal article

USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity

scientific article published on 24 November 2021

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

scientific article

Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression

scientific article

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

scientific article

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

scientific article

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

scientific article

p62/SQSTM1/A170: physiology and pathology

scientific article published on 25 July 2012

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

scientific article

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