List of works - Saumendra N Sarkar

A Specific Isozyme of 2′-5′ Oligoadenylate Synthetase Is a Dual Function Proapoptotic Protein of the Bcl-2 Family

scientific article published in Journal of Biological Chemistry

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation

Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs

scientific article

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

scientific article published on 12 June 2014

Could boosting the oligoadenylate synthetase-like pathway bring a new era of antiviral therapy?

scientific article published on January 2014

Crisscross Enzymatic Reaction between the Two Molecules in the Active Dimeric P69 Form of the 2′-5′ Oligodenylate Synthetase

scientific article published in Journal of Biological Chemistry

Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase

scientific article

Defective NF-κB signaling in metastatic head and neck cancer cells leads to enhanced apoptosis by double-stranded RNA.

scientific article

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

scientific article published on 27 August 2019

Differential activity of interferon-α8 promoter is regulated by Oct-1 and a SNP that dictates prognosis of glioma

scientific article

Differential effects of phenethyl isothiocyanate and D,L-sulforaphane on TLR3 signaling

scientific article published on 15 March 2013

Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain

scientific article published on 30 December 2002

Downregulation of IRF4 induces lytic reactivation of KSHV in primary effusion lymphoma cells

scientific article

Effect of fenvalerate, a pyrethroid insecticide on membrane fluidity.

scientific article published in April 1993

Effects of Mutating Specific Residues Present Near the Amino Terminus of 2′–5′-Oligoadenylate Synthetase

scientific article published in Journal of Biological Chemistry

Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein.

scientific article published in December 1997

Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

scientific article

Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling

scientific article published on February 2012

Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin

scientific article published on 02 December 2013

Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment

article

High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors

scientific article

Hitching RIG to action

scientific article

Human placental trophoblasts confer viral resistance to recipient cells

scientific article published on July 2013

Human β-defensin 3 promotes NF-κB-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck

scientific article

IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

scientific article published on 25 June 2019

Identification of the Substrate-binding Sites of 2′-5′-Oligoadenylate Synthetase

scientific article published in Journal of Biological Chemistry

Induction of interferon-stimulated genes by Simian virus 40 T antigens

scientific article

Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma

scientific article published on 18 March 2016

Integration of epidemiology, immunobiology, and translational research for brain tumors

scientific article

MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction

scientific article published on 25 March 2016

Mathematical Modeling of the cGAS Pathway Reveals Robustness of DNA Sensing to TREX1 Feedback

scientific article published on 03 November 2018

Novel functions of proteins encoded by viral stress-inducible genes

scientific article published in September 2004

Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

scientific article

OASL-a new player in controlling antiviral innate immunity

scientific article

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance

scientific article published on 27 August 2019

PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin

scientific article

Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation

scientific article

Production and Purification of Recombinant 2‘-5‘ Oligoadenylate Synthetase and Its Mutants Using the Baculovirus System ⬇️

scientific article published on March 17, 1998

Production, Purification, and Characterization of Recombinant 2′,5′-Oligoadenylate Synthetases ⬇️

scientific article published on July 1, 1998

Protective role of STING against gliomagenesis: Rational use of STING agonist in anti-glioma immunotherapy

scientific article published on 22 January 2015

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

scientific article published on 07 August 2019

Regulation of mitochondrial antiviral signaling (MAVS) expression and signaling by the mitochondria-associated endoplasmic reticulum membrane (MAM) protein Gp78.

scientific article

Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity

scientific article published on 4 January 2016

Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling

scientific article

Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells

scientific article published on 26 June 2013

STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment

scientific article published on 9 October 2014

Schizophrenia interactome with 504 novel protein-protein interactions

scientific article

Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase

scientific article published on 5 May 2014

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling

scientific article published on 29 April 2015

The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases

scientific article

The proapoptotic 9-2 isozyme of 2-5 (A) synthetase cannot substitute for the sperm functions of the proapoptotic protein, Bax.

scientific article published in February 2002

Transcriptional signaling by double-stranded RNA: role of TLR3.

scientific article

Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation

scientific article published on 18 December 2006

What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza?

scientific article

List of works by Saumendra N Sarkar

A Specific Isozyme of 2′-5′ Oligoadenylate Synthetase Is a Dual Function Proapoptotic Protein of the Bcl-2 Family

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation

Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

Could boosting the oligoadenylate synthetase-like pathway bring a new era of antiviral therapy?

Crisscross Enzymatic Reaction between the Two Molecules in the Active Dimeric P69 Form of the 2′-5′ Oligodenylate Synthetase

Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase

Defective NF-κB signaling in metastatic head and neck cancer cells leads to enhanced apoptosis by double-stranded RNA.

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

Differential activity of interferon-α8 promoter is regulated by Oct-1 and a SNP that dictates prognosis of glioma

Differential effects of phenethyl isothiocyanate and D,L-sulforaphane on TLR3 signaling

Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain

Downregulation of IRF4 induces lytic reactivation of KSHV in primary effusion lymphoma cells

Effect of fenvalerate, a pyrethroid insecticide on membrane fluidity.

Effects of Mutating Specific Residues Present Near the Amino Terminus of 2′–5′-Oligoadenylate Synthetase

Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein.

Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling

Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin

Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment

High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors

Hitching RIG to action

Human placental trophoblasts confer viral resistance to recipient cells

Human β-defensin 3 promotes NF-κB-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck

IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Identification of the Substrate-binding Sites of 2′-5′-Oligoadenylate Synthetase

Induction of interferon-stimulated genes by Simian virus 40 T antigens

Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma

Integration of epidemiology, immunobiology, and translational research for brain tumors

MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction

Mathematical Modeling of the cGAS Pathway Reveals Robustness of DNA Sensing to TREX1 Feedback

Novel functions of proteins encoded by viral stress-inducible genes

Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

OASL-a new player in controlling antiviral innate immunity

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance

PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin

Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation

Production and Purification of Recombinant 2‘-5‘ Oligoadenylate Synthetase and Its Mutants Using the Baculovirus System ⬇️

Production, Purification, and Characterization of Recombinant 2′,5′-Oligoadenylate Synthetases ⬇️

Protective role of STING against gliomagenesis: Rational use of STING agonist in anti-glioma immunotherapy

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

Regulation of mitochondrial antiviral signaling (MAVS) expression and signaling by the mitochondria-associated endoplasmic reticulum membrane (MAM) protein Gp78.

Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity

Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling

Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells

STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment

Schizophrenia interactome with 504 novel protein-protein interactions

Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling

The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases

The proapoptotic 9-2 isozyme of 2-5 (A) synthetase cannot substitute for the sperm functions of the proapoptotic protein, Bax.

Transcriptional signaling by double-stranded RNA: role of TLR3.

Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation

What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza?