List of works - Akira Kobayashi

A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain

scientific article

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.

scientific article

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

scientific article

Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein

scientific article published in July 2000

Constitutive activation of Drosophila CncC transcription factor reduces lipid formation in the fat body

scientific article published on 3 June 2015

Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene.

scientific article published on May 1996

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

scientific article

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms

scientific article (publication date: November 2011)

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

scientific article

Functional analysis of basic transcription element binding protein by gene targeting technology

scientific article

Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments.

scientific article published on December 2008

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

scientific article

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

scientific article

Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis

scientific article published on 13 February 2015

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells.

scientific article

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

scientific article

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

scientific article

Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.

scientific article published on 2 October 2017

NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner

scientific article published on 05 May 2016

New addiction to the NRF2-related factor NRF3 in cancer cells: Ubiquitin-independent proteolysis through the 20S proteasome

scientific article published on 14 December 2019

Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes

scientific article

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

scientific article (publication date: 2006)

Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element

scientific article

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

scientific article

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

scientific article

Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes.

scientific article published on 11 January 2017

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

scientific article (publication date: 17 February 2004)

Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1

scientific article

Roles of NRF3 in the Hallmarks of Cancer: Proteasomal Inactivation of Tumor Suppressors

scientific article published on 20 September 2020

Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.

scientific article

Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1.

scientific article published on 18 April 2008

Structure and expression of the mouse AhR nuclear translocator (mArnt) gene.

scientific article

Subcellular localization and cytoplasmic complex status of endogenous Keap1.

scientific article published in October 2007

The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence

scientific article

The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression

scientific article

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

scientific article

Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock

scientific article

USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression

scientific article published on 11 July 2016

β-Catenin/TCF4 Complex-Mediated Induction of the NRF3 (NFE2L3) Gene in Cancer Cells

scientific article published on 08 July 2019

List of works by Akira Kobayashi

A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein

Constitutive activation of Drosophila CncC transcription factor reduces lipid formation in the fat body

Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene.

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

Functional analysis of basic transcription element binding protein by gene targeting technology

Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments.

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells.

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.

NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner

New addiction to the NRF2-related factor NRF3 in cancer cells: Ubiquitin-independent proteolysis through the 20S proteasome

Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes.

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1

Roles of NRF3 in the Hallmarks of Cancer: Proteasomal Inactivation of Tumor Suppressors

Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.

Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1.

Structure and expression of the mouse AhR nuclear translocator (mArnt) gene.

Subcellular localization and cytoplasmic complex status of endogenous Keap1.

The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence

The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock

USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression

β-Catenin/TCF4 Complex-Mediated Induction of the NRF3 (NFE2L3) Gene in Cancer Cells