List of works - Jon Houtman

14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia.

scientific article

A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury.

scientific article

Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes.

scientific article published on 08 January 2014

Characterization of azido-NAD+ to assess its potential as a two-dimensional infrared probe of enzyme dynamics.

scientific article published on 10 August 2010

Characterization of the N-acetyl-5-neuraminic acid-binding site of the extracytoplasmic solute receptor (SiaP) of nontypeable Haemophilus influenzae strain 2019

scientific article

Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors

scientific article published on 01 October 1999

Evidence of a bacterial receptor for lysozyme: binding of lysozyme to the anti-σ factor RsiV controls activation of the ecf σ factor σV.

scientific article

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism.

scientific article

Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.

scientific article

Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement

scientific article

GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells

scientific article

GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.

scientific article published on 30 March 2015

Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics.

scientific article published on 26 July 2016

Glycerol monolaurate induces filopodia formation by disrupting the association between LAT and SLP-76 microclusters.

scientific article

Glycosylation contributes to variability in expression of murine cytomegalovirus m157 and enhances stability of interaction with the NK-cell receptor Ly49H.

scientific article

Growth hormone attenuation of epidermal growth factor-induced mitogenesis ⬇️

scientific article published on October 1, 1997

Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function.

scientific article

Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

scientific article published on 26 August 2013

Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines

scientific article published on 16 June 2017

Optimization of methods for the genetic modification of human T cells

scientific article

PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes.

scientific article

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

scientific article published on 16 September 2014

Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production

scientific article published on 21 November 2016

Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production

scientific article published on 12 October 2013

Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells.

scientific article

ROZA-XL, an improved FRET based biosensor with an increased dynamic range for visualizing zeta associated protein 70 kD (ZAP-70) tyrosine kinase activity in live T cells

scientific article

Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands

scientific article published on 12 June 2015

SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site

scientific article published in December 2017

Specificity residues determine binding affinity for two-component signal transduction systems

scientific article published on 5 November 2013

T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.

scientific article published on 9 April 2010

TCR-mediated functions are enhanced in activated peripheral blood T cells isolated from leucocyte reduction systems

scientific article

TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22.

scientific article published on 18 May 2017

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation

scientific article

The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1

scientific article (publication date: 22 February 2016)

The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.

scientific article

Yellow fever virus, but not Zika or Dengue virus inhibits T cell receptor-mediated T cell function by an RNA-based mechanism

scientific article published on 2 September 2017

List of works by Jon Houtman

14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia.

A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury.

Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes.

Characterization of azido-NAD+ to assess its potential as a two-dimensional infrared probe of enzyme dynamics.

Characterization of the N-acetyl-5-neuraminic acid-binding site of the extracytoplasmic solute receptor (SiaP) of nontypeable Haemophilus influenzae strain 2019

Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors

Evidence of a bacterial receptor for lysozyme: binding of lysozyme to the anti-σ factor RsiV controls activation of the ecf σ factor σV.

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism.

Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.

Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement

GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells

GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.

Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics.

Glycerol monolaurate induces filopodia formation by disrupting the association between LAT and SLP-76 microclusters.

Glycosylation contributes to variability in expression of murine cytomegalovirus m157 and enhances stability of interaction with the NK-cell receptor Ly49H.

Growth hormone attenuation of epidermal growth factor-induced mitogenesis ⬇️

Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function.

Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines

Optimization of methods for the genetic modification of human T cells

PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes.

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production

Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production

Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells.

ROZA-XL, an improved FRET based biosensor with an increased dynamic range for visualizing zeta associated protein 70 kD (ZAP-70) tyrosine kinase activity in live T cells

Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands

SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site

Specificity residues determine binding affinity for two-component signal transduction systems

T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.

TCR-mediated functions are enhanced in activated peripheral blood T cells isolated from leucocyte reduction systems

TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22.

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation

The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1

The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.

Yellow fever virus, but not Zika or Dengue virus inhibits T cell receptor-mediated T cell function by an RNA-based mechanism