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List of works by Alessandro Moretta

Activating KIRs and NKG2C in Viral Infections: Toward NK Cell Memory?

scientific article

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors

scientific article published on 8 May 2011

Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells

scientific article published on 01 March 2002

Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function.

scientific article published on 24 August 2006

Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)

scientific article

Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity

scientific article

B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape

scientific article published on 22 January 2015

Both CD133+ and CD133- medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity.

scientific article

Bridging innate NK cell functions with adaptive immunity.

scientific article published on January 2011

CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity

scientific article (publication date: December 2003)

Cellular ligands of activating NK receptors.

scientific article

Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals

scientific article

Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection

scientific article

Cognate HLA absence in trans diminishes human NK cell education

scientific article published on 29 August 2016

Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors

scientific article

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Conten

scientific article published on 10 October 2017

Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44.

scientific article

DNAM-1 and PVR regulate monocyte migration through endothelial junctions

scientific article

Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia

scientific article

Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response

scientific article

Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation

scientific article

Early liaisons between cells of the innate immune system in inflamed peripheral tissues.

scientific article

Effector and regulatory events during natural killer-dendritic cell interactions

scientific article published on December 2006

Expression and crystallographic characterization of the extracellular domain of human natural killer cell triggering receptor NKp46.

scientific article published on 27 November 2003

Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes.

scientific article published on 15 May 2003

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

scientific article

Features of Memory-Like and PD-1(+) Human NK Cell Subsets

scientific article

Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma

scientific article (publication date: 16 October 2003)

Functional characterization of natural killer cells in type I leukocyte adhesion deficiency

scientific article published on 01 February 2007

GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues.

scientific article

Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells.

scientific article published in June 2004

Human NK Cell Subsets Redistribution in Pathological Conditions: A Role for CCR7 Receptor

scientific article

Human NK cell infusions prolong survival of metastatic human neuroblastoma-bearing NOD/scid mice

scientific article published on 11 April 2007

Human NK cell response to pathogens

scientific article published on 28 February 2014

Human NK cells and NK receptors

scientific article published on 19 December 2013

Human natural killer cell function and their interactions with dendritic cells

scientific article

Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection

scientific article published on 19 December 2013

Human natural killer cells: their origin, receptors and function

scientific article (publication date: May 2002)

Human natural killer receptors and their ligands

scientific article published on February 2002

IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors

scientific article

IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors

scientific article

Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis

scientific article

Identification of HLA-E-specific alloreactive T lymphocytes: a cell subset that undergoes preferential expansion in mixed lymphocyte culture and displays a broad cytolytic activity against allogeneic cells

scientific article

Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys

scientific article published on 17 May 2005

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

scientific article

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

scientific article published on 27 May 2016

Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46

scientific article

Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages.

scientific article published on 12 July 2017

In the thick of the fray: NK cells in inflamed tissues.

scientific article published on January 2007

Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients.

scientific article published on 6 April 2017

Innate immunity defects in Hermansky-Pudlak type 2 syndrome

scientific article published on 28 February 2006

Innate or adaptive immunity? The example of natural killer cells

scientific article (publication date: 7 January 2011)

It's only innate immunity but I like it.

scientific article published on January 2007

Killer Ig–like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation ⬇️

scientific article published on January 20, 2011

Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals

scientific article

M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages

scientific article published in June 2012

Markers and function of human NK cells in normal and pathological conditions

scientific article published on 5 January 2017

Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor.

scientific article published on 25 May 2012

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

scientific article

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP ⬇️

scientific article published on November 1, 2011

NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy?

scientific article

NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27

scientific article

NK cells and their receptors during viral infections

scientific article published on September 2011

NK cells recognize and kill human glioblastoma cells with stem cell-like properties

scientific article

NK-DC interaction: on the usefulness of auto-aggression

scientific article

NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor

scientific article (publication date: 15 July 2005)

NK/DC crosstalk in anti-viral response.

scientific article published on January 2012

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content

scientific article

Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction.

scientific article

Natural killer cell-triggering receptors in patients with acute leukaemia.

scientific article published on October 2003

Natural killer cells and neuroblastoma: tumor recognition, escape mechanisms, and possible novel immunotherapeutic approaches

scientific article

Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates

scientific article

Neuroblastoma-derived TGF-β1 modulates the chemokine receptor repertoire of human resting NK cells.

scientific article published on 10 April 2013

Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages

scientific article published on 16 December 2015

PD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance

scientific article published on 15 July 2015

PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis

scientific article

Pathogen-induced private conversations between natural killer and dendritic cells.

scientific article

Phenotypic studies of natural killer cell subsets in human transporter associated with antigen processing deficiency

scientific article

Primitive neuroectodermal tumor in an ovarian cystic teratoma: natural killer and neuroblastoma cell analysis

scientific article published on 24 January 2014

Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors

scientific article

Role of alloreactive KIR2DS1(+) NK cells in haploidentical hematopoietic stem cell transplantation

scientific article published on 26 July 2011

Role of the 2B4 Receptor in CD8+ T-Cell-Dependent Immune Control of Epstein-Barr Virus Infection in Mice With Reconstituted Human Immune System Components

scientific article published on 26 February 2015

Selective cross-talk among natural cytotoxicity receptors in human natural killer cells

scientific article (publication date: May 2003)

Shaping of adaptive immunity by innate interactions

scientific article published in June 2004

Structure of the human NK cell triggering receptor NKp46 ectodomain

scientific article

Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1

scientific article

Surface NK receptors and their ligands on tumor cells

scientific article

Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells

scientific article

TGF-β1 Downregulates the Expression of CX3CR1 by Inducing miR-27a-5p in Primary Human NK Cells.

scientific article published on 25 July 2017

TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells

scientific article

TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses.

scientific article

TLR/NCR/KIR: Which One to Use and When?

scientific article published on 19 March 2014

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

scientific article

The Innate Immune Cross Talk between NK Cells and Eosinophils Is Regulated by the Interaction of Natural Cytotoxicity Receptors with Eosinophil Surface Ligands

scientific article published on 28 April 2017

The NK/DC complot

scientific article published on January 2009

The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic

scientific article published on February 2004

The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia

scientific article published on 26 August 2009

The immune inhibitory receptor LAIR-1 is highly expressed by plasmacytoid dendritic cells and acts complementary with NKp44 to control IFNα production

scientific article

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

scientific article

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

scientific article

The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes

scientific article

The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues

scientific article published on 03 January 2007

The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity

scientific article

Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells

scientific article

Update on natural killer cells: cross-talk with dendritic cells and role in the cure of acute myeloid leukemias

scientific article

Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction

scientific article published on 11 September 2009

Uptake of CCR7 by KIR2DS4⁺ NK cells is induced upon recognition of certain HLA-C alleles

scientific article published on 16 April 2015

X-linked lymphoproliferative disease: the dark side of 2b4 function

scientific article (publication date: 2001)

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